Abstract: The invention provides a compound of formula (1). or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.

Abstract: A support stand for supporting a volumetric modular unit above the ground is disclosed. The support stand includes a top portion with a top surface for contacting and supporting an underside of the modular unit above the ground. A bottom portion with a bottom surface supports the top portion at an elevation above the ground against the underside of the modular unit. An elevating portion has a top side connected to the top portion, a bottom side connected to the bottom portion, and an elevating span between the top side and the bottom side. A pad is connected to the bottom portion. The pad has a bottom surface for contacting and supporting the bottom portion against the ground, an inner pad perimeter and an outer pad perimeter. The top surface is parallel with the bottom surface. The underside and weight of the modular unit is supported on the top surface.

Abstract: The present invention is related to a method for the manufacture of a product that imitates properties of meat, poultry, fish, seafood, or products derived therefrom, comprising the step of dosing and depositing a first and optionally a second material onto a surface, preferably in a cavity (19), of a product carrier (16), preferably a mold, wherein at least one of said first material and second material comprises cellular medium, and at least one said first material and second material comprises a protein, preferably a vegetable protein, insect protein, cell protein including single cell protein, such as of yeast, bacteria, microalgae, fungi, fermented products, mold and the like, or a mixture of different proteins, wherein the protein content in the dry raw materials is 35 to 90%, preferably greater than 50% and is particularly preferably in the range from 60% to 90%.

Abstract: The present invention is related to a process for preparing a vegan cheese product, comprising the steps of metering raw materials into an extruder, comprising 5-50 wt.-% zein protein or starch, 0-50 wt.-% of at least one component that provides a fat phase mimicking the thermal behavior of milk fat, preferably a vegetable oil, and 30-70 wt.-% water, wherein all amounts are based on the entire amount of the raw materials, mixing and processing said raw materials in said extruder, extruding and cooling the resulting extrudate so as to obtain the vegan cheese product, wherein in said extruder strain conditions of 300-3000 WATS, preferably 1000 to 3000 WATS are applied. The present invention is also related to vegan cheese product obtainable by said process.

Abstract: The present invention is related to a method for the manufacture of a product that imitates properties of meat, poultry, fish, seafood, dairy products such as cheese or yoghurt, or products derived therefrom, comprising the step of dosing and depositing a first and optionally a second material onto a surface, preferably in a cavity (19), of a product carrier (16), preferably a mold, wherein at least one said first material and second material comprises a protein, preferably a vegetable protein, insect protein, cell protein including single cell protein, such as of yeast, bacteria, microalgae, fungi, fermented products, mold and the like, or a mixture of different proteins, wherein the protein content in the dry raw materials is 35 to 90%, preferably greater than 50% and is particularly preferably in the range from 60% to 90%.

Abstract: A wire cable construct including a plurality of strands each made of a plurality of wire filaments, the strands and wire filaments arranged in a 37×7 configuration of 37 strands of 7 wire filaments each, with the strands arranged in four layers including a first, central layer of a single strand, a second layer of six strands, a third layer of twelve strands and a fourth, outermost layer of eighteen strands. The cable may have a small diameter for use in medical device applications, and the strand and wire element configuration allows the cable to carry high axial loads, minimizes bending stress when the cable is routed around a tight turn such as a small pulley, and minimizes torsion in the cable due to axial loading.

Abstract: Aspects of the present disclosure relate to adverse user behavior detection and mitigation. In examples, a user account of a social platform may be trusted or untrusted. If the user account is untrusted, activity of the user account may be buffered so as to not directly affect social metrics of the social platform. For example, if the untrusted user account follows a target user account, the untrusted user account may be added to a separate set of followers or otherwise separated from a set of trusted followers of the target user account. Eventually, each user account in the separate set is evaluated to determine whether the user account has transitioned to a trusted user. If the user account is now trusted, it may be migrated to the set of trusted followers. However, if the user account is untrusted, it may be removed from the separate set, thereby reverting the activity.

Abstract: Modular robotic arms include modular sections with a joint and arm segment. In some examples, the modular sections may connect to each other using common tooling flanges, such as a standard robotic interface for an end effector. In the same or different examples, a robotic arm controller is located in a base or other section for the robotic arm. In the same or different examples, a robotic arm joint includes a differential gear with two motors. Coordinated control of the two differential joint motors facilitates both hinge and rotary motion for the joint.

Abstract: The invention provides a compound of formula (I): or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.

Abstract: Aspects of the present disclosure relate to adverse user behavior detection and mitigation. In examples, a user account of a social platform may be trusted or untrusted. If the user account is untrusted, activity of the user account may be buffered so as to not directly affect social metrics of the social platform. For example, if the untrusted user account follows a target user account, the untrusted user account may be added to a separate set of followers or otherwise separated from a set of trusted followers of the target user account. Eventually, each user account in the separate set is evaluated to determine whether the user account has transitioned to a trusted user. If the user account is now trusted, it may be migrated to the set of trusted followers. However, if the user account is untrusted, it may be removed from the separate set, thereby reverting the activity.

Abstract: A system comprising a spinning disk is disclosed. The system comprises a semiconductor processing system, such as a high energy implantation system. The semiconductor processing system produces a spot ion beam, which is directed to a plurality of workpieces, which are disposed on the spinning disk. The spinning disk comprises a rotating central hub with a plurality of platens. The plurality of platens may extend outward from the central hub and workpieces are electrostatically clamped to the platens. The plurality of platens may also be capable of rotation. The central hub also controls the rotation of each of the platens about an axis orthogonal to the rotation axis of the central hub. In this way, variable angle implants may be performed. Additionally, this allows the workpieces to be mounted while in a horizontal orientation.

Abstract: The present invention relates to a distribution device for an extruder, comprising at least two conduits leading away from a distribution unit, each conduit having a temperature-control device. The present invention further relates to an extrusion system comprising a distribution device of the above kind and to a method for producing a proteinaceous food item by means of the extrusion system.

Abstract: A neurosurgery system for probing brain tissue of a patient for tumorous tissue. The system including a suction tool, an excitation source, an optical instrument, and a controller. The suction tool including a suction cannula defining a lumen, an optical fiber configured to transmit fluorescence emitted by the brain tissue; and an indicator configured to selectively emit visible light. An excitation source is configured to emit an excitation light having a wavelength to induce the fluorescence in the tumorous tissue. The optical instrument is coupled to the optical fiber. The optical instrument configured to convert the fluorescence emitted by the brain tissue and transmitted by the optical and configured to determine that the brain tissue is tumorous based on the electrical signal and activate the indicator based on the determination.

Abstract: An aspiration system to control vacuum pressure in an ultrasonic surgical handpiece to result in improved control responsiveness during aspiration. The system comprises a console including a vacuum pump. The system includes a cassette comprising a joint that divides a vacuum path into at least two flow paths. A first joint port couples to a first flow path. A second flow path is coupled to a second joint port, a third flow path is coupled to a third joint port, and a fourth flow path is coupled to a port on a surgical waste receiver. A first sensor senses pressure in the fourth flow path and provides a waste receiver pressure signal. A second sensor senses pressure in the third flow path and provides a tip pressure signal. The controller controls a position of a first vent valve and a second vent valve based on the waste receiver pressure signal and the tip pressure signal, respectively.

Abstract: The disclosed systems and methods relate to allowing trading of over the counter (“OTC”) foreign exchange (“FX”) contracts on a centralized matching and clearing mechanism, such as that of the Chicago Mercantile Exchange's (“CME”'s) futures exchange system (the “Exchange”). The disclosed systems and methods allow for anonymous transactions, centralized clearing, efficient settlement and the provision of risk management/credit screening mechanisms to lower risk, reduce transaction costs and improve the liquidity in the FX market place. In particular, the disclosed embodiments increase speed of execution facilitating growing demand for algorithmic trading, increased price transparency, lower cost of trading, customer to customer trading, and automated asset allocations, recurring trades as well as clearing and settlement efficiencies.

Abstract: Ultra-High-Strength (UHS) wires are suited to high strength wire, strands, cables and rope applications including robotics force transmission and other high-performance mono- and multifilament wire applications. The wires exhibit high strength, low stretch and fatigue durability. Exemplary UHS materials include binary molybdenum-rhenium or tungsten-rhenium alloys with between 20 and 50 wt. % rhenium. These alloys are processed from a moderate strength (<2 GPa) warm-drawn rod to drawn monofilament wire with extreme nanocrystalline grain refinement, high apparent fatigue durability, and ultimate strength levels exceeding 5 GPa in all cases, and up to 6.8 GPa at monofilament diameters ranging from 7 to 100 ?m.