Abstract: The disclosure provides processes for synthesizing compounds for use as CFTR modulators.

Abstract: A coffee puck removal device (10) to remove a coffee puck (24) from a portafilter (20) is disclosed herein. The coffee puck removal device (10) has an open compartment (22) containing the coffee puck (24), the coffee puck (24) having an exposed major outer face (26) and a major inner face (28) when the coffee puck (24) is located in the open compartment (22). The device (10) includes: a body (12) having a rim (14) surrounding an aperture (16), with the rim (14) being configured to engage the portafilter (20), with the open compartment (22) facing the body (12) to inhibit air passing between the portafilter (20) and the rim (14); and a vacuum source (30) to remove air from the aperture (16) so that air pressure applied to the major inner face (28) is greater than air pressure applied to the exposed major outer face (26) so that the coffee puck (24) is removed from the portafilter (20).

Abstract: A suspending agent composition comprising (i) a fast hydrating guar gum and (ii) a high molecular weight polysaccharide, wherein the suspending agent composition has a rheological coupling ratio for yield point ranging from about 1 to about 2 when placed in an aqueous solution at a concentration of equal to or less than about 0.5 grams/deciliter and a ratio of about 90 weight percent (wt. %) fast hydrating guar gum and 10 wt. % high molecular weight polysaccharide. A wellbore servicing fluid comprising the suspending agent and methods of making and using the suspending agent.

Abstract: The invention relates generally to conjugated activatable antibodies that bind CD71 in their active form and methods of making and using these anti-CD71 conjugated activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.

Abstract: A filtration system interconnection structure having a filter manifold and a filter cartridge in magnetic communication with one another, such that a latching mechanism of the manifold secures the filter cartridge within a manifold sump when the filter cartridge is inserted therein. The magnetic communication is formed between two complementary coded polymagnets capable of producing a magnetic shear force when in close proximity to one another. The magnetic shear force removes a latch blocking structure from interfering with the latch, allowing the latch to secure the filter cartridge. Movement of the latch blocking structure coded polymagnet relative to the filter cartridge coded polymagnet may be perpendicular or parallel with respect to each other such that a shear force is generated therebetween, allowing for actuation of the latch blocking mechanism against a biasing force, and allowing the latch to move radially inwards against a separate biasing force.

Abstract: A circuit board assembly includes a circuit board and an electrical connector having a connector housing holding contacts in a contact array. The connector housing has a mating end configured to be mated with a mating electrical connector in a mating direction. The electrical connector has cables terminated to the contacts and extending from a cable end. A connector mount is used to locate the electrical connector relative to the circuit board. A bracket is coupled to the mounting surface of the circuit board. A biasing member is coupled to the bracket and the mounting feature and is compressible along a compression axis parallel to the mating direction to allow the electrical connector to float in the mating direction relative to the circuit board.

Abstract: Examples provide a door assembly including a dual operation slide device for a sliding privacy door associated with a seat unit. The door assembly includes a sliding door movably mounted to a door support member of a seat unit. The door slides laterally between a retracted position and a deployed or partially deployed position. The dual operation slide device includes a trigger and release mechanism for switching the door assembly from a primary track system used during a normal operation mode to a secondary track system used during a backup operation mode if the primary track becomes jammed or otherwise malfunctions based on manual activation of a release lever or force applied activation. The dual operation slide device enables a user to return the sliding door to a retracted position after a failure of the primary slide units to operate in the normal operational mode.

Abstract: An environmental-efficiency fluid is designed by a system and/or method. The fluid can be for use in a down-hole operation in a well. The design produces the environmental-efficiency fluid from a treatment fluid and drill cuttings. For example, the system and method can include creating an analysis of a rheological model generated from a set of wellbore conditions and a set of drill-cutting properties to determine a set of rheological properties for the treatment fluid and a concentration of drill cuttings, which allow for use of the drill cuttings with the treatment fluid; and producing the environmental-efficiency fluid based on the rheological properties and the concentration of drill cuttings.

Abstract: A system for plant cultivation includes decks having an upper face and a lower face, the decks disposed in a vertical array, each deck having sides connected at corners, each corner extending outward beyond the sides to form a protuberance.

Abstract: A circuit board assembly includes an electrical connector mounted to a circuit board having a connector housing holding contacts in a contact array. A connector mount having a bracket is coupled to the mounting surface of the circuit board proximate to the mating edge. The electrical connector is movably coupled to the connector mount to move relative to the circuit board during mating with the mating electrical connector. The connector mount has a biasing member compressible along a compression axis parallel to the mating direction to allow the electrical connector to float in the mating direction relative to the circuit board. The electrical connector is movably coupled to the connector mount in a confined envelope in at least one floating direction perpendicular to the mating direction.

Abstract: An electrical connector includes wafer assemblies coupled to a housing. Each wafer assembly includes a leadframe, a wafer body holding the leadframe, and a ground frame coupled to the wafer body to provide electrical shielding for the leadframe. Each leadframe has signal contacts with mating ends extending from the wafer body for mating with mating signal contacts of a mating electrical connector. The mating ends are twisted 45° to define twisted mating interfaces. Each ground frame has ground shields extending from a ground plate along the mating ends of the signal contacts. The ground shields are twisted 45° relative to the ground plate to define twisted shield zones along the mating ends of the signal contacts.

Abstract: Techniques are described for consistently moving powder from a hopper into a trough for subsequent delivery into a build area of an additive fabrication system. A powder delivery apparatus may comprise a hopper, a trough, and a doser. The doser may be configured to rotate about an axis and may include a recess that, when the doser is rotated about the axis, travels into and out of the hopper and into and out of the trough. As a result, when powder is present in the hopper, the recess may carry powder from the hopper to the trough when the doser rotates. The trough and doser may be configured so that when the trough contains the desired amount of powder for recoating, the doser does not transfer additional material from the hopper into the trough. As a result, the amount of powder in the trough may be self-regulating.

Abstract: Techniques are described for consistently moving powder from a hopper into a trough for subsequent delivery into a build area of an additive fabrication system. A powder conveyer may be arranged at least partially within the hopper and configured to be actuated to transfer powder to the trough. The powder conveyer may be formed as a screw conveyor, for example. Such techniques do not require complex closed-loop control systems and may be effective irrespective of the flowability of the powder. In at least some cases, there may be no production of excess powder because the amount of powder that is metered into the trough may be precisely controlled to be the amount needed for recoating.

Abstract: Techniques are described for consistently moving powder from a hopper into a trough for subsequent delivery into a build area of an additive fabrication system. A powder delivery apparatus may comprise a hopper, a trough, and a doser. The doser may be configured to rotate about an axis and may include a recess that, when the doser is rotated about the axis, travels into and out of the hopper and into and out of the trough. As a result, when powder is present in the hopper, the recess may carry powder from the hopper to the trough when the doser rotates. The trough and doser may be configured so that when the trough contains the desired amount of powder for recoating, the doser does not transfer additional material from the hopper into the trough. As a result, the amount of powder in the trough may be self-regulating.

Abstract: There is provided an apparatus for heating a pot of food or beverage, the apparatus comprising at least one receptacle (20), each receptacle for temporarily receiving a pot of food or beverage to be heated. Each receptacle comprises a base (22), sidewalls (24), and an opening opposite from the base (22) for receiving the pot; a heater element (43) mounted to the sidewalls; a temperature sensor (45) mounted to the base; a pot sensor (40, 41) for detecting whether or not a pot is present in the receptacle; and a controller connected to the heater element, temperature sensor, and pot sensor. The controller is configured to control the heater element in response to the pot sensor and temperature sensor.

Abstract: A curing system includes a basin configured to receive a photopolymer resin, an ultraviolet light source, and a translating device. The ultraviolet light source is configured to selectively emit ultraviolet light. The ultraviolet light defines a pixelated array that illuminates at least a portion of the photopolymer resin. The pixelated array includes a first array axis and a second array axis oriented perpendicular to the first array axis. The translating device is configured to translate the pixelated array along a translation axis at an oblique angle relative to the first array axis.

Abstract: A split cycle internal combustion engine includes a combustion cylinder accommodating a combustion piston and a compression cylinder accommodating a compression piston. The engine also includes a controller arranged to receive an indication of a parameter associated with the combustion cylinder and/or a fluid associated therewith and to control an exhaust valve of the combustion cylinder in dependence on the indicated parameter to cause the exhaust valve to close during the return stroke of the combustion piston, before the combustion piston has reached its top dead centre position (TDC), when the indicated parameter is less than a target value for the parameter; and close on completion of the return stroke of the combustion piston, as the combustion piston reaches its top dead centre position (TDC), when the indicated parameter is equal to or greater than the target value for the parameter.

Abstract: There is provided an apparatus for heating a pot of food or beverage, the apparatus comprising at least one receptacle (20), each receptacle for temporarily receiving a pot of food or beverage to be heated. Each receptacle comprises a base (22), sidewalls (24), and an opening opposite from the base (22) for receiving the pot; a heater element (43) mounted to the sidewalls; a temperature sensor (45) mounted to the base; a pot sensor (40, 41) for detecting whether or not a pot is present in the receptacle; and a controller connected to the heater element, temperature sensor, and pot sensor. The controller is configured to control the heater element in response to the pot sensor and temperature sensor.

Abstract: A split cycle internal combustion engine comprising a compression cylinder accommodating a compression piston; a combustion cylinder accommodating a combustion piston; a crossover passage between the compression cylinder and the combustion cylinder arranged to provide working fluid to the combustion cylinder; a controller arranged to determine a peak temperature of combustion in the combustion cylinder based on a received indication of a peak temperature of combustion in the combustion cylinder; and a coolant system arranged to regulate a temperature of the working fluid supplied to the combustion cylinder; wherein, in response to determining that the peak temperature of combustion exceeds a selected threshold, the controller is configured to control the coolant system to regulate the temperature of the working fluid supplied to the combustion cylinder so that a peak temperature of combustion in the combustion cylinder is less than the selected threshold.

Abstract: Methods and apparatus are disclosed for efficient cooling within air liquefaction processes with integrated use of cold recycle from a thermal energy store.