Abstract: A machine-learning-based method for analyzing, negotiating, and drafting contracts that provides the user with information regarding market terms for particular industries and geographic locations.

Abstract: A machine-learning-based method for analyzing, negotiating, and drafting contracts that provides the user with information regarding market terms for particular industries and geographic locations.

Abstract: This invention is directed to methods for the facile and accurate identification of cancer cells in a tissue sample, such as a surgical field. In particular, the compositions and methods employ conjugates comprising pro-fluorescent fluorescein based moieties bound to folic or pteroic acid targeting moiety optionally through a linker. The pro-fluorescent fluorescein based moieties are non-fluorescent but capable of being rendered fluorescent by intracellular processes. The conjugates are employed to detect cancer cells that overexpress folic acid receptors thereby providing for differential accumulation of these conjugates in these cells.

Abstract: Disclosed are folic acid or pteroic acid conjugates and methods for using such conjugates. The conjugates described herein comprise a chemotherapeutic drug or imaging agent covalently bound thereto through a bond or via a linker that is intracellularly disrupted by, e.g., endogenous enzymes such as esterases, lipases and the like so as to provide for the chemotherapeutic drug free of the folic or pteroic acid.

Abstract: One form of the present application provides a system comprising an illumination source capable of providing an electromagnetic illumination of an engine component, an imaging system structured to capture illumination of the engine component, a component manipulation system structured to position the engine component in a variety of orientations relative to one of the illumination source and the imaging system, a computer based user interface capable of identifying an inspection protocol defined to acquire an image of the engine component at the variety of positions using the illumination system, the imaging system and the component manipulation system, and a processor configured to process the inspection protocol for the purposes of analyzing the acquired image in response to the inspection protocol.

Abstract: An apparatus of an automated object manipulation system includes a support base; a finger assembly mechanically coupled to the support base; a first drive unit operable to rotate the finger assembly about a first axis; a second drive unit operable to rotate the finger assembly about a second axis; a third drive unit operable to rotate the finger assembly about a third axis, and a processor capable of conducting a profile assessment; determining a manipulation program in response to the profile assessment; and controlling the finger assembly in response to the manipulation program where the finger assembly has a support bracket with a set of parallel jaws and the support bracket is mechanically coupled to the first drive unit, a linking bracket mechanically coupled to the second drive unit and a circular frame mechanically coupled to the finger assembly and the third drive unit.

Abstract: A system including a positioning system with a component manipulator structured to position a component in response to a positioning algorithm; a scanning system capable of producing a set of light waves directed at a surface of the component, detecting a set of reflected light waves from the surface of the component, and producing a reflectivity data set in response to the set of reflected light waves; and a microprocessor structured to apply a fuzzy logic algorithm to the reflectivity signal to determine a solution set and produce a grain structure characterization in response to the solution set.

Abstract: An apparatus includes a positioning system; a surface indicator system to collect an indication data set from a surface of a component utilizing a fluorescent penetration process; an indication data processing system to create an output data set in response to the indication data set utilizing a fuzzy logic algorithm; and a microprocessor to provide at least one surface variance in response to the indication data set and the output data set. A method including conducting a surface indication technique for a component; utilizing a positioning algorithm to manipulate positioning equipment in response to the component; directing an indication source to a surface of the component; collecting an indication data set in response to directing the indication source; applying a fuzzy logic analysis in response to the indication data set to provide an output data set; and providing at least one surface variance in response to the output data set.

Abstract: A proliferation of cells can be reduced by contacting the cells with a compound having formula (I) where R and R? are each alkyl groups, R? is hydrogen or an alkyl group and X3, X4 and X5 are each independently selected from the group consisting of hydrogen, benzyl, t-butyldimethylsiloxy radical and triphenylmethyl. Accordingly, compounds of formula (I) can be used for treatment of tumors including melanoma. Also a secretion of a matrix metalloproteinase (MMP) enzyme by cells can be reduced by contacting the cells with the compound having formula (I). Accordingly, compounds of formula (I) can be used for treatment physiological conditions associated with an elevated MMP level, such as tumors.

Abstract: A method for inspecting surfaces including acquiring a surface image from a surface of a component; providing an image registration for the surface image; inspecting the component in response to the image registration to produce an input data set; creating an output data set in response to the input data set utilizing a fuzzy logic algorithm; and identifying a surface feature in response to the surface image and the output data set where acquiring the surface image further includes generating a radiation media; directing the radiation media at the component; detecting a responding radiation media in response to the directed radiation media and the component; creating the surface image in response to detecting the responding radiation media; and adjusting the generation of the radiation media in response to the surface image and a standard image.

Abstract: An apparatus for an illumination system including a concentric light source providing a quantity of light; a diffusion shield to diffuse the light and produce a diffused illumination where the diffused illumination is provided to a component positioned in an interior portion of the diffusion shield; a support structure where the diffusion shield is mechanically coupled with the support structure at a first base portion of the diffusion shield and where the concentric light sources are mechanically coupled with the support structure and positioned radially outward from the first base portion of the diffusion shield; and a harvesting shield where the harvesting shield is mechanically coupled with the support structure and positioned radially outward from the concentric light sources and where the harvesting shield redirects at least a portion of the quantity of light from the concentric light sources towards the diffusion shield.

Abstract: A method for inspecting surfaces including acquiring a surface image from a surface of a component; providing an image registration for the surface image; inspecting the component in response to the image registration to produce an input data set; creating an output data set in response to the input data set utilizing a fuzzy logic algorithm; and identifying a surface feature in response to the surface image and the output data set where acquiring the surface image further includes generating a radiation media; directing the radiation media at the component; detecting a responding radiation media in response to the directed radiation media and the component; creating the surface image in response to detecting the responding radiation media; and adjusting the generation of the radiation media in response to the surface image and a standard image.

Abstract: An apparatus for an illumination system including a concentric light source providing a quantity of light; a diffusion shield to diffuse the light and produce a diffused illumination where the diffused illumination is provided to a component positioned in an interior portion of the diffusion shield; a support structure where the diffusion shield is mechanically coupled with the support structure at a first base portion of the diffusion shield and where the concentric light sources are mechanically coupled with the support structure and positioned radially outward from the first base portion of the diffusion shield; and a harvesting shield where the harvesting shield is mechanically coupled with the support structure and positioned radially outward from the concentric light sources and where the harvesting shield redirects at least a portion of the quantity of light from the concentric light sources towards the diffusion shield.

Abstract: An apparatus includes a positioning system; a surface indicator system to collect an indication data set from a surface of a component utilizing a fluorescent penetration process; an indication data processing system to create an output data set in response to the indication data set utilizing a fuzzy logic algorithm; and a microprocessor to provide at least one surface variance in response to the indication data set and the output data set. A method including conducting a surface indication technique for a component; utilizing a positioning algorithm to manipulate positioning equipment in response to the component; directing an indication source to a surface of the component; collecting an indication data set in response to directing the indication source; applying a fuzzy logic analysis in response to the indication data set to provide an output data set; and providing at least one surface variance in response to the output data set.

Abstract: A system including a positioning system with a component manipulator structured to position a component in response to a positioning algorithm; a scanning system capable of producing a set of light waves directed at a surface of the component, detecting a set of reflected light waves from the surface of the component, and producing a reflectivity data set in response to the set of reflected light waves; and a microprocessor structured to apply a fuzzy logic algorithm to the reflectivity signal to determine a solution set and produce a grain structure characterization in response to the solution set.

Abstract: An apparatus of an automated object manipulation system includes a support base; a finger assembly mechanically coupled to the support base; a first drive unit operable to rotate the finger assembly about a first axis; a second drive unit operable to rotate the finger assembly about a second axis; a third drive unit operable to rotate the finger assembly about a third axis, and a processor capable of conducting a profile assessment; determining a manipulation program in response to the profile assessment; and controlling the finger assembly in response to the manipulation program where the finger assembly has a support bracket with a set of parallel jaws and the support bracket is mechanically coupled to the first drive unit, a linking bracket mechanically coupled to the second drive unit and a circular frame mechanically coupled to the finger assembly and the third drive unit.

Abstract: One form of the present application provides a system comprising an illumination source capable of providing an electromagnetic illumination of an engine component, an imaging system structured to capture illumination of the engine component, a component manipulation system structured to position the engine component in a variety of orientations relative to one of the illumination source and the imaging system, a computer based user interface capable of identifying an inspection protocol defined to acquire an image of the engine component at the variety of positions using the illumination system, the imaging system and the component manipulation system, and a processor configured to process the inspection protocol for the purposes of analyzing the acquired image in response to the inspection protocol.

Abstract: Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided.

Abstract: A proliferation of cells can be reduced by contacting the cells with a compound having formula (I) where R and R? are each alkyl groups, R? is hydrogen or an alkyl group and X3, X4 and X5 are each independently selected from the group consisting of hydrogen, benzyl, t-butyldimethylsiloxy radical and triphenylmethyl. Accordingly, compounds of formula (I) can be used for treatment of tumors including melanoma. Also a secretion of a matrix metalloproteinase (MMP) enzyme by cells can be reduced by contacting the cells with the compound having formula (I). Accordingly, compounds of formula (I) can be used for treatment physiological conditions associated with an elevated MMP level, such as tumors.