Abstract: The invention provides a compound of formula (I): or a pharmaceutically-acceptable salt thereof, that is an inhibitor of JAK kinases. The invention also provides pharmaceutical compositions comprising such compound, a crystalline form, methods of using such compound to treat inflammatory skin diseases and other diseases, and processes and intermediates useful for preparing such compound.

Abstract: A method for real-time invoice updating and account-to-account payment includes: receiving invoice data based on presentation of an invoice by a distributor to a recipient at a delivery location, modification of the invoice by the recipient, and acceptance of the invoice by the recipient; generating a request for payment (RFP) message based on the invoice data; transmitting the RFP message to a financial institution associated with the recipient via a financial institution of the distributor; receiving, from the financial institution associated with the distributor, a payment confirmation for the invoice based on a real-time payment from the financial institution associated with the recipient; generating reconciliation data based on the payment confirmation and the invoice data; and transmitting the reconciliation data to a computing device of the distributor and a computing device of the recipient.

Abstract: Compositions and methods of treating a subject for a coronavirus infection are provided. The methods typically include administering the subject an effective amount of probenecid, a metabolite or anaolg thereof, or a pharmaceutically acceptable salt thereof. The methods can by therapeutic and/or prophylactic. The amount of probenecid or a pharmaceutically acceptable salt thereof can be effective to, for example, reduce viral replication, reduce one or more symptoms of disease, disorder, or illness associated with virus, or a combination thereof. In preferred embodiments, the virus is a Severe acute respiratory syndrome-related coronavirus such as SARS-CoV-2 or SARS-CoV, a Middle East respiratory syndrome-related coronavirus such as MERS-CoV, or a coronavirus that causes the common cold.

Abstract: An apparatus is disclosed herein. The apparatus comprises a non-linear photonic element for outputting a signal and idler photon pair. The apparatus further comprises a module configured to, based on receiving one or more control signals, controllably store photons and controllably output stored photons. The apparatus further comprises a detector arrangement comprising one or more detectors for detecting light. The module is further configured to receive at least one of the signal and idler photons of the pair. The module is further configured to at least partially store one of the signal or idler photons of the pair. The module is further configured to output the said at least partially stored signal or idler photon along an optical path towards the at least one detectors. The apparatus is configured to direct the other of the signal or idler photon towards the detector arrangement.

Abstract: Hybrid polypeptides that agonize the GIP, GLP-1 and neuropeptide Y2 (NPY2) receptors and their medical use in the treatment of a variety of diseases, conditions or disorders, such as obesity, diabetes, and/or NASH are disclosed. The polypeptides have the general structure Z1-Z2-Z3, wherein Z1 is a hybrid polypeptide providing GIPR and GLP1R agonism, Z2 is a linker, and Z3 is a polypeptide providing hY2R agonism.

Abstract: An access door may include a core, first and second stiles defined along opposites sides of the core such that the core between the first and second stiles defines a recessed pocket with each of the first and second stiles defining a channel therein extending longitudinally along an inwardly-facing edge thereof, bottom and top elongated panels each defining tongue members at opposite sides thereof and configured to be received transversely in the recessed pocket with the tongue members received within the channels defined along the inwardly-facing edges of the first and second stiles, wherein, with the top and bottom elongated panels received in the recessed pocket, exterior faces of the first and second stiles, exterior faces of the top and bottom elongated panels, and an exposed surface of the recessed pocket between the top and bottom elongated panels define an exterior surface of one side of the door.

Abstract: The invention relates to an ophthalmoscope (10) configured to acquire video of an eye. The ophthalmoscope (10) comprises a light source, an imaging apparatus (20), and a processor. The light source emits a beam of non-coherent light which in use impinges on the eye. The imaging apparatus (20) acquires plural images of at least part of the eye, each of the plural images acquired when non-coherent light from the light source impinges on the eye. The processor is configured to at least one of: control the imaging apparatus (20) such that time adjacent images are acquired with a predetermined period therebetween; and record a time of acquisition of each of a plurality of the plural images and to associate each time of acquisition with the respective image. The acquired plural images are thus related in time to one another and thereby constitute video of the eye.

Abstract: In an aspect, a self-balancing two-wheeled vehicle is provided, having a body, and first and second wheels rotatably coupled to the body. The second wheel has at least one lateral roller rotatable about an axis that is one of oblique and orthogonal to a rotation axis of the second wheel. At least one motor is coupled to the second wheel to control rotation of the second wheel and the at least one lateral roller. At least one sensor is coupled to the body to generate orientation data therefor. A control module is coupled to the at least one motor to control operation thereof at least partially based on the orientation data generated by the at least one sensor.

Abstract: The invention provides a compound of formula (I): or a pharmaceutically-acceptable salt thereof, that is an inhibitor of JAK kinases. The invention also provides pharmaceutical compositions comprising such compound, a crystalline form, methods of using such compound to treat inflammatory skin diseases and other diseases, and processes and intermediates useful for preparing such compound.

Abstract: Provided herein are compounds of formula (I): and pharmaceutically-acceptable salts thereof, where A, W, X, Y and Z are defined in the specification. The compounds of formula (I) and pharmaceutically-acceptable salts thereof are Janus kinase (JAK) inhibitors. Also provided herein are pharmaceutical compositions comprising such compounds; and methods of using such compounds to treat, e.g., inflammatory and fibrotic diseases, including respiratory diseases.

Abstract: A fuel vapor recirculation system includes a filler neck adapted to receive a refueling nozzle that dispenses fuel into the filler neck. A fuel tank receives fuel from the filler neck through an inlet check valve. The check valve is disposed in the fuel inlet opening and is normally closed. The check valve opens when fuel is dispensed into the fuel tank. The check valve defines a vent hole that is always open. The fuel tank also includes a fuel limiting vent valve and a grade limit vent valve. A fuel vapor cannister collects fuel vapor and selectively supplies fuel vapor to an intake manifold of a vehicle. The fuel vapor recirculation manifold receives fuel vapor only from the fuel limiting vent valve and the grade limit vent valve in the fuel tank and does not receive fuel vapor directly from the filler neck.

Abstract: A fuel vapor recirculation system includes a filler neck adapted to receive a refueling nozzle that dispenses fuel into the filler neck. A fuel tank receives fuel from the filler neck through an inlet check valve. The check valve is disposed in the fuel inlet opening and is normally closed. The check valve opens when fuel is dispensed into the fuel tank. The check valve defines a vent hole that is always open. The fuel tank also includes a fuel limiting vent valve and a grade limit vent valve. A fuel vapor cannister collects fuel vapor and selectively supplies fuel vapor to an intake manifold of a vehicle. The fuel vapor recirculation manifold receives fuel vapor only from the fuel limiting vent valve and the grade limit vent valve in the fuel tank and does not receive fuel vapor directly from the filler neck.

Abstract: The invention relates to coated paper where a base paper is coated at least on one side and where the coating comprises at least 5 wt. % carbon material and at least 5 wt. % of an open-framework material and at least 1 wt. % binder, a process for the manufacture of the means, a composition for coating paper, coated paper, a process for the manufacture of the coated paper, a means for storing electricity, use of the coated paper as well as a method for storing electricity.

Abstract: The subject invention relates to a variety of formulations of bipolar trans carotenoids including pharmaceutical compositions for oral delivery of a bipolar trans carotenoid comprising i) a bipolar trans carotenoid, ii) a cyclodextrin, and iii) a coating. The invention also relates to preparation of such formulations and their uses.

Abstract: Systems and methods for efficient upstream multicast in passive optical networks. An upstream multicast source communicates an upstream multicast packet to the network. Subsequent downstream packet management achieved through use of source filters prevents a reflected copy of the original upstream multicast packets from being received by the upstream multicast source.

Abstract: A drill press has a main housing, a drill unit supported by the main housing for relative movement therewith, and a base coupled to the main housing, the base includes a magnet assembly to create a magnetic field for magnetically latching the base to a workpiece. The magnet assembly is rotatably attached to the base and includes a shaft and at least one permanent magnet disposed on the shaft. The shaft is rotatable between a first position where the base would not magnetically engage the workpiece and a second position where the base would engage the workpiece. An auxiliary handle is pivotably attached to the main housing and movable from a first handle position preventing removal of a power tool battery pack from the main housing and a second handle position allowing removal of the power tool battery pack from the main housing.

Abstract: The disclosure provides compounds of formula (I): or a pharmaceutically-acceptable salt thereof, wherein the variables are defined in the specification, that are inhibitors of JAK kinases, particularly JAK3. The disclosure also provides pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat gastrointestinal inflammatory diseases.

Abstract: In an aspect, a self-balancing two-wheeled vehicle is provided, having a body, and first and second wheels rotatably coupled to the body. The second wheel has at least one lateral roller rotatable about an axis that is one of oblique and orthogonal to a rotation axis of the second wheel. At least one motor is coupled to the second wheel to control rotation of the second wheel and the at least one lateral roller. At least one sensor is coupled to the body to generate orientation data therefor. A control module is coupled to the at least one motor to control operation thereof at least partially based on the orientation data generated by the at least one sensor.

Abstract: Features for a lightweight stereoscopic viewing client are described. The client can generate accurate ground point coordinates from selections within the lightweight viewer by accumulating the transformations from original image sources to the images used to render the stereoscopic scene to accurately predict error for a point selection. The viewer may also be decoupled from a permanent image store allowing on-demand retrieval of images via a network for stereoscopic viewing.

Abstract: A method of delivering and deploying a prosthetic valve includes percutaneously advancing a catheter to a treatment site, proximally retracting an outer shaft relative to an inner shaft to expose the prosthetic valve such that the prosthetic valve self-expands to a radially expanded configuration, disconnecting a tip retractor from a handle of the catheter, and proximally retracting the tip retractor to proximally retract the inner shaft and a nosecone attached to a distal end of the inner shaft relative to the outer shaft and/or the handle.