Patents by Inventor Robert N. Eisenman

Robert N. Eisenman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acids encoding max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc and Mad
    Patent number: 5693487
    Abstract: Nucleic acid molecules capable of hybridizing under stringent conditions to the nucleotide sequence of the max cDNAs shown in SEQ ID NO: 1 or SEQ ID NO: 2, or to the nucleotide sequence of the mad cDNAs shown in SEQ ID NO: 5. The Max polypeptide when associated with the Myc or Mad polypeptide is capable of binding to nucleotide sequences containing CACGTG.
    Type: Grant
    Filed: April 1, 1994
    Date of Patent: December 2, 1997
    Assignee: Fred Hutchinson Cancer Research Center
    Inventors: Elizabeth M. Blackwood, Robert N. Eisenman
  • Nucleic acids encoding regulatory proteins that dimerize with Mad or Max
    Patent number: 5624818
    Abstract: An isolated nucleic acid molecule capable of hybridizing under stringent conditions to the mSinA nucleotide sequence shown in FIG. 22 (SEQ ID NO:11), the mSin9A nucleotide sequence shown in FIG. 28 (SEQ ID NO:17), and/or the mSinB nucleotide sequence shown in FIG. 30 (SEQ ID NO:19). This isolated nucleic acid molecule preferably encodes a recombinant polypeptide which associates with a Mad polypeptide to form a recombinant polypeptide:Mad complex, which preferably associates with a Max polypeptide to form a recombinant polypeptide:Mad:Max complex, which preferably binds to a nucleotide sequence comprising CACGTG (SEQ ID NO:16). An isolated nucleic acid molecule capable of hybridizing under stringent conditions to a nucleotide sequence selected from among clone 10 shown in FIG. 24 (SEQ ID NO:9), clone 18 shown in FIG. 25 (SEQ ID NO:10), clone 19 shown in FIG. 26 (SEQ ID NO:11), and clone 20 shown in FIG. 27 (SEQ ID NO:12).
    Type: Grant
    Filed: June 1, 1994
    Date of Patent: April 29, 1997
    Assignee: Fred Hutchinson Cancer Research Center
    Inventors: Robert N. Eisenman, Donald E. Ayer
  • Method of producing a Mad polypeptide
    Patent number: 5302519
    Abstract: Nucleic acid molecules capable of hybridizing under stringent conditions to the nucleotide sequence residing between positions 1 and 453 of the max cDNAs shown in FIG. 2, or to the nucleotide sequence residing between positions 148 and 810 of the mad cDNAs shown in FIG. 14. The Max polypeptide when associated with the Myc or Mad polypeptide is capable of binding to nucleotide sequences containing CACGTG.
    Type: Grant
    Filed: June 23, 1992
    Date of Patent: April 12, 1994
    Assignee: Fred Hutchinson Cancer Research Center
    Inventors: Elizabeth M. Blackwood, Robert N. Eisenman, Donald E. Ayer, Jr.