Patents by Inventor Robert N. Grass
Robert N. Grass has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240011076Abstract: One or more enzymes are used to repair damage in synthetic DNA molecules that encode digital information. The enzymes are included in a repair mixture containing one or more of DNA polymerase, DNA ligase, T4 Endonuclease, Endonuclease IV, Endonuclease VIII, and uracil glycosylase. The repair mixture may also contain one or more of a buffering solution, oxidized nicotinamide adenine dinucleotide (NAD+), and deoxyribose nucleoside triphosphates (dNTPs). The synthetic DNA molecules are incubated with the repair mixture for approximately four hours. Use of the repair solution allows recovery of the digital information from damaged DNA molecules.Type: ApplicationFiled: August 31, 2023Publication date: January 11, 2024Inventors: Robert N. GRASS, Alexander Xavier Christof KOHLL, Weida CHEN
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Publication number: 20230399676Abstract: The invention describes methods and kits for purifying nucleic acids from samples utilizing a novel wash buffer based on DMSO.Type: ApplicationFiled: October 15, 2021Publication date: December 14, 2023Applicant: PROTONDX LIMITEDInventor: Robert N. GRASS
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Patent number: 11781169Abstract: One or more enzymes are used to repair damage in synthetic DNA molecules that encode digital information. The enzymes are included in a repair mixture containing one or more of DNA polymerase, DNA ligase, T4 Endonuclease, Endonuclease IV, Endonuclease VIII, and uracil glycosylase. The repair mixture may also contain one or more of a buffering solution, oxidized nicotinamide adenine dinucleotide (NAD+), and deoxyribose nucleoside triphosphates (dNTPs). The synthetic DNA molecules are incubated with the repair mixture for approximately four hours. Use of the repair solution allows recovery of the digital information from damaged DNA molecules.Type: GrantFiled: October 5, 2018Date of Patent: October 10, 2023Assignee: MICROSOFT TECHNOLOGY LICENSING, LLCInventors: Robert N. Grass, Alexander Xavier Christof Kohll, Weida Chen
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Publication number: 20230012888Abstract: A data storage medium is disclosed comprising a two-dimensional (2D) support structure onto which artificially synthesized DNA molecules encoding digital information are placed and then covered with a protective layer. The 2D support structure is formed from a material such as metal foil, glass, or plastic. The 2D support structure may be functionalized with positively charged molecules to improve DNA adhesion. The DNA is protected from degradation by encapsulation in a protective layer of a non-reactive material such as silica or a thin layer of metal. A process for storing DNA on 2D support structures is also disclosed. Correlation of specific DNA molecules with a physical storage location on a 2D support structure provides geometric addressability for selective access to specific digital information.Type: ApplicationFiled: September 27, 2022Publication date: January 19, 2023Inventors: Karin STRAUSS, Bichlien Hoang NGUYEN, Robert N. GRASS, Alexander Xavier Christof KOHLL, Weida CHEN
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Patent number: 11539516Abstract: The invention is notably directed to a method for encoding information. This method first comprises generating an encryption key according to polymorphic features of nucleic acids from one or more entities. Next, information is encrypted based on the generated key. Finally, the encrypted information is encoded into synthetic DNA. Another aspect concerns a method for retrieving information. Consistently with the above encoding scheme, synthetic DNA in provided, which encodes encrypted information. Such information is read by sequencing the synthetic DNA and by decrypting the information read using a decryption key. The latter is generated according to polymorphic features of nucleic acids from one or more entities (e.g., from the legitimate individual(s) requesting access to information). Thus, the encoded information cannot be interpreted unless a suitable decryption key is available. The invention is further directed to related DNA samples and systems, including DNA vaults.Type: GrantFiled: September 25, 2018Date of Patent: December 27, 2022Assignee: ETH ZURICHInventors: Robert N. Grass, Wendelin Jan Stark
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Patent number: 11485965Abstract: A data storage medium is disclosed comprising a two-dimensional (2D) support structure onto which artificially synthesized DNA molecules encoding digital information are placed and then covered with a protective layer. The 2D support structure is formed from a material such as metal foil, glass, or plastic. The 2D support structure may be functionalized with positively charged molecules to improve DNA adhesion. The DNA is protected from degradation by encapsulation in a protective layer of a non-reactive material such as silica or a thin layer of metal. A process for storing DNA on 2D support structures is also disclosed. Correlation of specific DNA molecules with a physical storage location on a 2D support structure provides geometric addressability for selective access to specific digital information.Type: GrantFiled: November 2, 2018Date of Patent: November 1, 2022Assignee: MICROSOFT TECHNOLOGY LICENSING, LLCInventors: Karin Strauss, Bichlien Hoang Nguyen, Robert N. Grass, Alexander Xavier Christof Kohll, Weida Chen
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Publication number: 20220326681Abstract: Methods and systems for sequence-controlled polymer encoding, decoding, and storage are provided. In various embodiments, input data is encoded into one or more sequence controlled polymer, wherein encoding the input data comprises applying an error-correction code. The one or more sequence-controlled polymer are synthesized. The synthesized one or more sequence-controlled polymer are encapsulated in a plurality of particles. The plurality of particles are embedded into a feedstock.Type: ApplicationFiled: June 17, 2020Publication date: October 13, 2022Applicant: ETH ZURICHInventors: Robert N. Grass, Yaniv Ehrlich
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Publication number: 20210194686Abstract: The invention is notably directed to a method for encoding information. This method first comprises generating an encryption key according to polymorphic features of nucleic acids from one or more entities. Next, information is encrypted based on the generated key. Finally, the encrypted information is encoded into synthetic DNA. Another aspect concerns a method for retrieving information. Consistently with the above encoding scheme, synthetic DNA in provided, which encodes encrypted information. Such information is read by sequencing the synthetic DNA and by decrypting the information read using a decryption key. The latter is generated according to polymorphic features of nucleic acids from one or more entities (e.g., from the legitimate individual(s) requesting access to information). Thus, the encoded information cannot be interpreted unless a suitable decryption key is available. The invention is further directed to related DNA samples and systems, including DNA vaults.Type: ApplicationFiled: September 25, 2018Publication date: June 24, 2021Inventors: Robert N. GRASS, Wendelin Jan STARK
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Publication number: 20210046475Abstract: The present invention relates in a first aspect to a metallic sample holder (1), in particular for capturing sample volumes for digital polymerase chain detection. The sample holder (1) comprises an array of indentations (10), wherein each indentation (11) is adapted to capture a maximal sample volume vmax, with vmax=2 nl, in particular with vmax=1 nl, in particular with vmax=0.8 nl. Each indentation (11) of the array (10) has an area cross-section section a, with a ?8*10?3 mm2, in particular with a ?5*10?3 mm2. A second aspect of the invention relates to a method for manufacturing the sample holder (1). A third aspect of the invention relates to an apparatus (200), in particular for polymerase chain reaction detection, adapted for receiving the metallic sample holder (1). A fourth aspect of the invention relates to the use of the sample holder (1) by means of the apparatus (200).Type: ApplicationFiled: December 20, 2018Publication date: February 18, 2021Inventors: Wendelin Jan Stark, Robert N. Grass, Michele Gregorini
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Publication number: 20200140849Abstract: A data storage medium is disclosed comprising a two-dimensional (2D) support structure onto which artificially synthesized DNA molecules encoding digital information are placed and then covered with a protective layer. The 2D support structure is formed from a material such as metal foil, glass, or plastic. The 2D support structure may be functionalized with positively charged molecules to improve DNA adhesion. The DNA is protected from degradation by encapsulation in a protective layer of a non-reactive material such as silica or a thin layer of metal. A process for storing DNA on 2D support structures is also disclosed. Correlation of specific DNA molecules with a physical storage location on a 2D support structure provides geometric addressability for selective access to specific digital information.Type: ApplicationFiled: November 2, 2018Publication date: May 7, 2020Inventors: Karin STRAUSS, Bichlien Hoang NGUYEN, Robert N. GRASS, Alexander Xavier Christof KOHLL, Weida CHEN
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Publication number: 20200109436Abstract: One or more enzymes are used to repair damage in synthetic DNA molecules that encode digital information. The enzymes are included in a repair mixture containing one or more of DNA polymerase, DNA ligase, T4 Endonuclease, Endonuclease IV, Endonuclease VIII, and uracil glycosylase. The repair mixture may also contain one or more of a buffering solution, oxidized nicotinamide adenine dinucleotide (NAD+), and deoxyribose nucleoside triphosphates (dNTPs). The synthetic DNA molecules are incubated with the repair mixture for approximately four hours. Use of the repair solution allows recovery of the digital information from damaged DNA molecules.Type: ApplicationFiled: October 5, 2018Publication date: April 9, 2020Inventors: Robert N. Grass, Alexander Xavier Christof Kohll, Weida Chen
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Patent number: 10577654Abstract: The present invention relates to core-shell particles comprising encapsulated nucleic acids—a sensing sequence and a control sequence; the invention further relates to the use of such particles as a sensing element; to methods for measuring a property of interest in a setting employing such particles; to measuring systems and analytical kits comprising such particles.Type: GrantFiled: April 19, 2016Date of Patent: March 3, 2020Assignee: ETH ZurichInventors: Robert N. Grass, Wendelin Jan Stark, Gediminas Mikutis, Michela Puddu
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Patent number: 10156028Abstract: The present invention relates to the manufacturing gelatin fibers comprising the steps of: (a) preparing a two-phase composition as defined in the claims, (b) spinning the lower phase of said composition, (c) stretching the obtained fiber and (d) optional finishing steps; to new gelatin fibers and to the use thereof.Type: GrantFiled: May 21, 2014Date of Patent: December 18, 2018Assignee: ETH ZurichInventors: Philipp R. Stoessel, Robert N. Grass, Wendelin Jan Stark
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Publication number: 20180119220Abstract: The present invention relates to core-shell particles comprising encapsulated nucleic acids—a sensing sequence and a control sequence; the invention further relates to the use of such particles as a sensing element; to methods for measuring a property of interest in a setting employing such particles; to measuring systems and analytical kits comprising such particles.Type: ApplicationFiled: April 19, 2016Publication date: May 3, 2018Applicant: ETH ZURICHInventors: Robert N. GRASS, Wendelin Jan STARK, Gediminas MIKUTIS, Michela PUDDU
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Patent number: 9850531Abstract: The present invention relates to a method for protecting and. recovering nucleic acids. This method may be applied in a verification method of products using molecular code systems or it may be applied in a storage method for nucleic acids. The invention further provides specific particles, their use in secure marking; products suitable for such verification method, to processes for manufacturing such products and methods for reading the information.Type: GrantFiled: March 26, 2013Date of Patent: December 26, 2017Assignee: ETH ZurichInventors: Robert N. Grass, Wendelin Jan Stark
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Publication number: 20160130729Abstract: The present invention relates to the manufacturing gelatin fibers comprising the steps of: (a) preparing a two-phase composition as defined in the claims, (b) spinning the lower phase of said composition, (c) stretching the obtained fiber and (d) optional finishing steps; to new gelatin fibers and to the use thereof.Type: ApplicationFiled: May 21, 2014Publication date: May 12, 2016Applicant: ETH ZURICHInventors: Philipp R. Stoessel, Robert N. Grass, Wendelin Jan Stark
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Publication number: 20150030545Abstract: The present invention relates to a method for protecting and. recovering nucleic acids. This method may be applied in a verification method of products using molecular code systems or it may be applied in a storage method for nucleic acids. The invention further provides specific particles, their use in secure marking; products suitable for such verification method, to processes for manufacturing such products and methods for reading the information.Type: ApplicationFiled: March 26, 2013Publication date: January 29, 2015Applicant: ETH ZURICHInventors: Robert N. GRASS, Wendelin Jan STARK
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Patent number: 8801936Abstract: The invention relates to a process for separating a dispersed phase from a continuous phase comprising the steps of i) contacting said phases with an effective amount of nanoparticles; ii) applying a magnetic field gradient to the obtained system; iii) separating the obtained phases wherein said nanoparticles are of the core shell type, said core consists of a metal or alloy having soft magnetic properties and said shell contains a graphene layers which are optionally functionalized; to new nanoparticles and method of manufacturing such nanoparticles.Type: GrantFiled: November 2, 2007Date of Patent: August 12, 2014Assignee: ETH ZürichInventors: Robert N. Grass, Wendelin Jan Stark
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Patent number: 8282911Abstract: The present relates to the field of dental and bone surgery. In particular, the invention relates to fibrous pharmaceutical compositions; fibrous webs, yarns and woven fabrics of such pharmaceutical compositions; to implant material essentially consisting of fibrous pharmaceutical compositions; to the manufacturing and use of such fibers/webs/implant materials.Type: GrantFiled: October 23, 2006Date of Patent: October 9, 2012Assignees: ETH Zürich, Universitat ZürichInventors: Jan W. Stark, Oliver Schneider, Stefan Loher, Tobias Brunner, Marc Simonet, Patrick Schmidlin, Robert N. Grass
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Patent number: 8182573Abstract: The present invention relates the manufacture of metal powders, non-oxidic ceramic powders and reduced metal oxide powders using an improved flame spray pyrolysis (“FSP”) process. The invention further relates to an apparatus specifically adapted to said process, to powders/naoncomposites obtained by said process and to the use of said powders/nanocompsites.Type: GrantFiled: September 4, 2006Date of Patent: May 22, 2012Assignee: ETH ZürichInventors: Wendelin Stark, Robert N. Grass, Evagelos-Kimon Athanassiou