Patents by Inventor Robert N. Hanson

Robert N. Hanson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10385093
    Abstract: Compounds useful for molecular imaging of cells expressing estrogen receptors are provided. Also provided are intermediates for making the compounds and methods of making the compounds using a modular convergent strategy. Further, methods of making the intermediates are described, as well as methods of diagnosing disease in a subject by using the compounds as imaging agents.
    Type: Grant
    Filed: December 10, 2013
    Date of Patent: August 20, 2019
    Assignee: Northeastern University
    Inventors: Robert N. Hanson, Kinh-Luan Dao
  • Publication number: 20180141911
    Abstract: A new class of quinoline compounds is useful for the detection and treatment of Alzheimer's disease and other neurodegenerative diseases such as amyloidoses and tauopathies. The compounds can be synthesized in radiolabeled form for use as imaging agents, which can be used for early detection of aggregates in the brain or other tissues prior to onset of symptoms, allowing early therapeutic intervention. The compounds are also useful for the prevention and treatment of such diseases.
    Type: Application
    Filed: May 16, 2016
    Publication date: May 24, 2018
    Inventor: Robert N. HANSON
  • Publication number: 20150344518
    Abstract: Compounds useful for molecular imaging of cells expressing estrogen receptors are provided. Also provided are intermediates for making the compounds and methods of making the compounds using a modular convergent strategy. Further, methods of making the intermediates are described, as well as methods of diagnosing disease in a subject by using the compounds as imaging agents.
    Type: Application
    Filed: December 10, 2013
    Publication date: December 3, 2015
    Inventors: Robert N. Hanson, Kinh-Luan Dao
  • Patent number: 9056129
    Abstract: A method of preparing multifunctionalized nanoparticles involves using a modular system of half-linkers to attach functional moieties that serve to deliver the nanoparticles to a desired target, exert an effect at the target, or track the nanoparticles within a cell or an animal. The modular chemistry of the half-linker system permits the custom design and synthesis of functionalized nanoparticles bearing multiple groups and therefore results in precise delivery to desired cell types and intracellular locations. The functionalized nanoparticles can be used to treat or diagnose a variety of medical conditions, including neoplastic diseases, infectious diseases, and chronic diseases.
    Type: Grant
    Filed: February 11, 2008
    Date of Patent: June 16, 2015
    Assignee: Northeastern University
    Inventors: Robert N. Hanson, Mansoor Amiji, Volkmar Weissig
  • Patent number: 8173628
    Abstract: The present invention comprises the design, synthesis and development of a new class of chemotherapeutic agents for prophylactic and therapeutic treatments in a mammal, particularly a human, believed to be at risk of suffering from a hormone-responsive disorder. In an aspect of the invention, such treatments include therapeutic compositions comprising novel steroidal antiestrogen and antiandrogen compounds. In a preferred aspect, such a novel compound of the present invention has an address and a message component, which are made into a single composite entity for more aggressive intervention and effective treatment of hormone-responsive disorders, thereby prolonging the disease-free interval for the patient and reducing a number of side effects.
    Type: Grant
    Filed: October 19, 2007
    Date of Patent: May 8, 2012
    Assignee: Northeastern University
    Inventors: Robert N. Hanson, Carolyn Friel, Choon Young Lee
  • Publication number: 20120046461
    Abstract: Disclosed are novel compounds and compositions for inhibition of androgen and estrogen receptor signaling, methods for inhibiting androgen signaling, methods for inhibiting estrogen signaling, methods for inhibiting the interaction between a co-regulatory protein and an androgen or estrogen receptor, and methods for treating cancer.
    Type: Application
    Filed: January 25, 2010
    Publication date: February 23, 2012
    Applicant: Northeastern University
    Inventor: Robert N. Hanson
  • Publication number: 20110105608
    Abstract: Disclosed are novel compounds and compositions for inhibition of androgen and estrogen receptor signaling, methods for inhibiting androgen signaling, methods for inhibiting estrogen signaling, methods for inhibiting the interaction between a co-regulatory protein and an androgen or estrogen receptor, and methods for treating cancer.
    Type: Application
    Filed: March 23, 2009
    Publication date: May 5, 2011
    Applicant: NORTHEASTERN UNIVERSITY
    Inventor: Robert N. Hanson
  • Publication number: 20100260676
    Abstract: A method of preparing multifunctionalized nanoparticles involves using a modular system of half-linkers to attach functional moieties that serve to deliver the nanoparticles to a desired target, exert an effect at the target, or track the nanoparticles within a cell or an animal. The modular chemistry of the half-linker system permits the custom design and synthesis of functionalized nanoparticles bearing multiple groups and therefore results in precise delivery to desired cell types and intracellular locations. The functionalized nanoparticles can be used to treat or diagnose a variety of medical conditions, including neoplastic diseases, infectious diseases, and chronic diseases.
    Type: Application
    Filed: February 11, 2008
    Publication date: October 14, 2010
    Applicant: NORTHEASTERN UNIVERSITY
    Inventors: Robert N. Hanson, Mansoor Amiji, Volkmar Weissig
  • Publication number: 20080166301
    Abstract: The present invention comprises the design, synthesis and development of a new class of chemotherapeutic agents for prophylactic and therapeutic treatments in a mammal, particularly a human, believed to be at risk of suffering from a hormone-responsive disorder. In an aspect of the invention, such treatments include therapeutic compositions comprising novel steroidal antiestrogen and antiandrogen compounds. In a preferred aspect, such a novel compound of the present invention has an address and a message component, which are made into a single composite entity for more aggressive intervention and effective treatment of hormone-responsive disorders, thereby prolonging the disease-free interval for the patient and reducing a number of side effects.
    Type: Application
    Filed: October 19, 2007
    Publication date: July 10, 2008
    Inventors: Robert N. Hanson, Carolyn Friel, Choon Young Lee
  • Patent number: 7141573
    Abstract: One aspect of the present invention relates to polypharmacophoric compounds. In certain embodiments, the polyphamacophore compounds comprise individual pharmacophore units selected from the group consisting of D-1 agonists, D-2 agonists, D-3 agonists, D-4 agonists, irreversible monoamine inhibitors, reversible monoamine inhibitors, monoamine transporter inhibitors, COMT inhibitors, MAO inhibitors, and dopamine transporter inhibitors. Moreover, the present invention also relates to combinatorial libraries of polypharmacophoric compounds. Another aspect of the present invention relates to the use of a polypharmacophoric compound in a method of treating a mammal in need thereof. For example, a polypharmacophoric compound of the present invention may be used in a method of treating a mammal afflicted with Alzheimer's Disease, Huntington's Disease, depression, attention deficit disorder, autism, obesity, or inflammation.
    Type: Grant
    Filed: January 11, 2001
    Date of Patent: November 28, 2006
    Assignee: Molecular Insight Pharmaceuticals, Inc.
    Inventors: Robert N. Hanson, John W. Babich
  • Patent number: 7041839
    Abstract: The present invention comprises the design, synthesis and development of a new class of chemotherapeutic agents for prophylactic and therapeutic treatments in a mammal, particularly a human, believed to be at risk of suffering from a hormone-responsive disorde. In an embodiment of the invention, such treatments include therapeutic compositions comprising novel steroidal antiestrogen and antiandrogen compounds. In a preferred embodiment, such a novel compound of the present invention has an address and a message component, which are made into a single composite entity for more aggressive intervention and effective treatment of hormone-responsive disorders, thereby prolonging the disease-free interval for the patient and reducing a number of side effects.
    Type: Grant
    Filed: June 22, 2001
    Date of Patent: May 9, 2006
    Assignee: Northeastern University
    Inventors: Robert N. Hanson, Carolyn Friel, Choon Young Lee
  • Publication number: 20040002484
    Abstract: The present invention comprises the design, synthesis and development of a new class of chemotherapeutic agents for prophylactic and therapeutic treatments in a mammal, particularly a human, believed to be at risk of suffering from a hormone-responsive disorde. In an embodiment of the invention, such treatments include therapeutic compositions comprising novel steroidal antiestrogen and antiandrogen compounds. In a preferred embodiment, such a novel compound of the present invention has an address and a message component, which are made into a single composite entity for more aggressive intervention and effective treatment of hormone-responsive disorders, thereby prolonging the disease-free interval for the patient and reducing a number of side effects.
    Type: Application
    Filed: December 4, 2002
    Publication date: January 1, 2004
    Inventors: Robert N Hanson, Carolyn Friel, Choon Young Lee
  • Publication number: 20020042357
    Abstract: One aspect of the present invention relates to polypharmacophoric compounds. In certain embodiments, the polyphamacophore compounds comprise individual pharmacophore units selected from the group consisting of D-1 agonists, D-2 agonists, D-3 agonists, D-4 agonists, irreversible monoamine inhibitors, reversible monoamine inhibitors, monoamine transporter inhibitors, COMT inhibitors, MAO inhibitors, and dopamine transporter inhibitors. Moreover, the present invention also relates to combinatorial libraries of polypharmacophoric compounds. Another aspect of the present invention relates to the use of a polypharmacophoric compound in a method of treating a mammal in need thereof. For example, a polypharmacophoric compound of the present invention may be used in a method of treating a mammal afflicted with Alzheimer's Disease, Huntington's Disease, depression, attention deficit disorder, autism, obesity, or inflammation.
    Type: Application
    Filed: January 11, 2001
    Publication date: April 11, 2002
    Inventors: Robert N. Hanson, John W. Babich
  • Patent number: 6251363
    Abstract: Diamine compounds useful for treating neurodegenerated diseases characterized by the lack of dopamine neurons activity or for imaging the dopamine neurons are provided.
    Type: Grant
    Filed: November 1, 1999
    Date of Patent: June 26, 2001
    Assignees: The General Hospital, Northeastern University
    Inventors: David R. Elmaleh, Robert N. Hanson, Choi Sung-Woon
  • Patent number: 6001330
    Abstract: Diamine compounds useful for treating neurodegenerated diseases characterized by the lack of dopamine neurons activity or for imaging the dopamine neurons are provided. The diamine compounds or serotonin are characterized by the formula: ##STR1## wherein: l, m and n can be the same or different and are an integer of 1 to 6; X, Y and Z can be the same or different and are hydrogen, halo, haloalkyl, (C.sub.1 -C.sub.6) alkyl, aryl, (C.sub.1 -C.sub.6) alkoxy, N-alkyl, (C.sub.2 -C.sub.6) acyloxy, N-alkylene, --SH, or --SR, wherein R is from the same group as R.sub.1 and R.sub.2 and can be the same or different than R.sub.1 and R.sub.2, amino, nitro, cyano, hydroxy, --C(.dbd.O) OR.sub.6, --C(.dbd.O) NR.sub.5 R.sub.4, NR.sub.3 R.sub.2, or S(.dbd.O).sub.k R.sub.1 wherein .sub.k is 1 or 2, and R.sub.4 to R.sub.6 are independently hydrogen or (C.sub.1 -C.sub.6) alkyl;R.sub.1, and R.sub.2 can be the same or different and are hydrogen, (C.sub.1 -C.sub.6) alkyl, hydroxyalkyl or mercaptoalkyl, --C(.dbd.O) OR.sub.
    Type: Grant
    Filed: September 12, 1997
    Date of Patent: December 14, 1999
    Inventors: David R. Elmaleh, Robert N. Hanson, Choi Sung-Woon
  • Patent number: 5853696
    Abstract: Disclosed are certain cocaine analogs useful for imaging of cocaine receptors and dopamine receptors. Also disclosed are analogs useful for imaging diagnostics for Parkinson's disease.
    Type: Grant
    Filed: February 20, 1996
    Date of Patent: December 29, 1998
    Assignees: Organix, Inc., The General Hospital Corporation, The President and Fellows of Harvard College, Northeastern University
    Inventors: David R. Elmaleh, Bertha K. Madras, Peter Meltzer, Robert N. Hanson
  • Patent number: 5493026
    Abstract: Disclosed are certain cocaine analogs useful for imaging of cocaine receptors and dopamine receptors. Also disclosed are analogs useful for imaging diagnostics for Parkinson's disease.
    Type: Grant
    Filed: October 25, 1993
    Date of Patent: February 20, 1996
    Assignees: Organix, Inc., The General Hospital Corporation, President and Fellows of Harvard College, Northeastern University
    Inventors: David R. Elmaleh, Bertha K. Madras, Robert N. Hanson, Peter Meltzer
  • Patent number: 4972927
    Abstract: A ball bearing brake has a spindle with a central axis. Each member of a pair of caliper members has a lever and a brake pad arm. The members are fitted on the spindle for rotation around the axis, and for limited axial movement during assembly and adjustment. Each brake pad arm carries a brake pad to be pressed against a bicycle wheel. An end member mountable to the bicycle structure includes means to engage the spindle and to compress a stack between itself and a head on the spindle. Four sets of bearing balls are formed around the spindle, respectively confined (1) by a race adjustment to the head of the spindle and one of the lever arms (2) by a race on the first lever arm and on an intermediate race member (3) by another race on the intermediate race member and on the other lever arm, and (4) between a race on the said other lever arm and a race adjacent to the end member.
    Type: Grant
    Filed: November 1, 1988
    Date of Patent: November 27, 1990
    Inventors: Charles W. Stephens, Robert N. Hanson
  • Patent number: D438155
    Type: Grant
    Filed: May 22, 1997
    Date of Patent: February 27, 2001
    Inventor: Robert N. Hanson