Patents by Inventor Robert N. Nishimura

Robert N. Nishimura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160235859
    Abstract: The invention provides methods for selective targeting of live cells, which have undergone or are undergoing radiation or chemotherapy, at a site of interest with a cell-penetrating polypeptide. In one embodiment of the invention, the method comprises contacting the live cells with a cell-penetrating polypeptide comprising cell-penetrating determinants so that the cell-penetrating polypeptide binds extracellular DNA near or around the live cells so as to form a complex or association therewith such that the complex or associated polypeptide-DNA so bound bind the live cells and penetrates the live cells thereby selectively targeting live cells at a site of interest with a cell-penetrating polypeptide.
    Type: Application
    Filed: February 18, 2016
    Publication date: August 18, 2016
    Inventors: Richard H. Weisbart, Robert N. Nishimura
  • Patent number: 9283272
    Abstract: The invention provides a method for inhibiting an intracellular target in a cell with a bispecific antibody comprising contacting the cell with a bispecific antibody having a first Fv fragment with a cell-penetrating determinant and a second Fv fragment with an intracellular target-binding determinant under suitable conditions so that the first Fv fragment causes the bispecific antibody to enter the cell and the second Fv fragment binds the intracellular target in the cell and thereby inhibiting the intracellular target.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: March 15, 2016
    Assignee: The United States of America as represented by the Department of Veterans Affairs
    Inventors: Richard H. Weisbart, Robert N. Nishimura
  • Publication number: 20140234309
    Abstract: The invention provides for a fusion protein comprising a 3E10 Fv joined to a Hsp-70, Hsp-27, Hsp-90 or GRP-78or portion thereof, and optionally, the 3E10 Fv comprising an amino acid sequence AGIH at its amino terminus.
    Type: Application
    Filed: March 15, 2013
    Publication date: August 21, 2014
    Inventors: Robert N. Nishimura, Richard H. Weisbart
  • Publication number: 20140050723
    Abstract: Antibodies that penetrate cell nuclei and inhibit DNA repair or interfere with DNA metabolism are provided for treatment of cancer (both directly and by sensitizing cancer cells to DNA-damaging treatments) or inhibiting or preventing viral infection, proliferation or metabolism. The method involves treating cells with a composition containing cell-penetrating anti-DNA antibodies or derivatives thereof, alone or in combination with treatment that induces DNA damage such as DNA-damaging chemotherapy or radiation. The impact of the cell-penetrating anti-DNA antibodies or derivatives thereof is potentiated in cancer cells that are deficient in DNA repair, and the cell-penetrating anti-DNA antibodies or derivatives thereof are synthetically lethal to cancer cells with DNA repair deficiencies.
    Type: Application
    Filed: April 2, 2012
    Publication date: February 20, 2014
    Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, YALE UNIVERSITY
    Inventors: James E. Hansen, Peter M. Glazer, Richard H. Weisbart, Robert N. Nishimura, Grace Chan
  • Publication number: 20130266570
    Abstract: The invention provides a method for inhibiting an intracellular target in a cell with a bispecific antibody comprising contacting the cell with a bispecific antibody having a first Fv fragment with a cell-penetrating determinant and a second Fv fragment with an intracellular target-binding determinant under suitable conditions so that the first Fv fragment causes the bispecific antibody to enter the cell and the second Fv fragment binds the intracellular target in the cell and thereby inhibiting the intracellular target.
    Type: Application
    Filed: March 15, 2013
    Publication date: October 10, 2013
    Inventors: Richard H. Weisbart, Robert N. Nishimura
  • Publication number: 20130259862
    Abstract: The invention provides for a fusion protein comprising a 3E10 Fv joined to a Hsp-70, Hsp-27, Hsp-90 or GRP-78 or portion thereof, and optionally, the 3E10 Fv comprising an amino acid sequence AGIH at its amino terminus.
    Type: Application
    Filed: March 16, 2013
    Publication date: October 3, 2013
    Inventors: Robert N. Nishimura, Richard H. Weisbart