Abstract: A method and apparatus includes a housing defining an internal cavity, wherein the housing includes at least a first exhaust gas inlet for exhaust gas at a first temperature and a second exhaust gas inlet for exhaust gas at a second temperature greater than the first temperature. The housing further includes at least a first outlet to atmosphere and a second outlet to at least one storage component. At least one heating element is positioned within the internal cavity. Adsorption material is located within the internal cavity, and at least one flow guide directs exhaust gas through the adsorption material from the first exhaust gas inlet to the first outlet.

Abstract: There is described a food supplement composition comprising a cucumber (Cucumis sativus) extract which in particular reduces the TNF-? level. Raw cucumber extract can inhibit the production of TNF-? in human blood without causing adverse immune reactions. It has therefore been shown that raw cucumber extract can be effectively used as food supplement product or as dietary supplement for a prolonged time for the prevention and treatment of TNF-? level dependant inflammation states.

Abstract: Described are various compounds, in particular iminosugars, and methods for the treatment of proteostatic diseases, in particular lysosomal storage disorders. The compound may be a pharmacoperone of an enzyme selected from: (a) Acid alpha-glucosidase; (b) Acid beta-glucosidase; (c) glucocerebrosidase; (d) alpha-Galactosidase A; (e) Acid beta-galactosidase; (f) beta-Hexosaminidase A; (g) beta-Hexosaminidase B; (h) Acid sphingomyelinase; (i) Galactocerebrosidase; (j) Acid ceramidase; (k) Arylsulfatase A; (l) alpha-L-Iduronidase; (m) Iduronate-2-sulfatase; (n) Heparan N-sulfatase; (o) alpha-N-Acetylglucosaminidase; (p) Acetyl-CoA: alpha-glucosaminide N-acetyltransferase; (q) N-Acetylglucosamine-6-sulfate sulfatase; (r) N-Acetylgalactosamine-6-sulfate sulfatase; (s) Acid beta-galactosidase; (t) Arylsulfatase B; (u) beta-Glucuronidase; (v) Acid alpha-mannosidase; (w) Acid beta-mannosidase; (x) Acid alpha-L-fucosidase; (y) Sialidase; and (z) alpha-N-acetylgalactosaminidase.

Abstract: Described are various compounds and methods for the treatment of flaviviral infections. In particular, alkaloids and imino sugars in arabinose and/or lyxose stereochemical configuration with antiflaviviral activity are described.

Abstract: Described are various compounds and methods for the treatment of disorders arising from aberrant protein folding, including in particular lysosomal storage diseases. In particular, polyhydroxylated alkaloids and imino sugars which are pharmacoperones of an enzyme and which do not bind to a catalytic site of said enzyme are described.

Abstract: Isolated immunomodulatory (e.g. immunostimulatory) polyhydroxlated pyrrolizidine compounds having the formula are disclosed. In these compounds R is selected from hydrogen, straight or branched, unsubstituted or substituted, saturated or unsaturated acyl, alkyl (e.g. cycloalkyl), alkenyl, alkynyl and aryl groups. The compounds are useful in therapy and prophylaxis, including increasing the Th1:Th2 response ratio, hemorestoration, alleviation of immunosuppression, cytokine stimulation, treatment of proliferative disorders (e.g. cancer), vaccination, stimulation of the innate immune response and boosting of the activity of endogenous NK cells.

Abstract: A method for monitoring the quality of a herbal medicine comprising the steps of: (a) providing a sample of the herbal medicine (b) extracting the sample with a polar solvent to produce a polar extract (c) subjecting the polar extract to ion-exchange chromatography to produce an extract enriched in ionic compounds (d) chromatographically fractionating the enriched extract to yield one or more polar fractions (e) characterizing the polar fractions.

Abstract: A system includes a plurality of distributed refrigeration units respectively coupled to discrete refrigeration circuits. Each refrigeration unit may include a variable compressor, a fixed compressor, a condensing unit, and a controller. The controller compares an operating condition of the refrigeration unit to a refrigeration circuit set point to select a compressor staging capable of achieving the refrigeration circuit set point.

Abstract: A process comprises the steps of: providing a natural (e.g. plant) material; extracting a first sample of the material with a polar solvent to produce a polar extract and a non-polar residue; subjecting the polar extract to ion-exchange chromatography to produce an extract enriched in ionic-compounds and a non-ionic residue; and chromatographically fractionating the enriched extract to yield one or more polar fractions comprising one or more ionic (phyto)chemical(s).