Abstract: There is disclosed a composition comprising cannabidiol (CBD) and one or more cannabinoids selected from cannabidiolic acid (CBDA), cannabigerol (CBG) and cannabigerolic acid (CBGA) for use in the treatment or prevention of inflammation and disorders associated with inflammation or an IL-6 related disorder.

Abstract: Methods, systems, and computer program products are provided that enable users to provide explicit declarations that are used to generate recommendations for the users. An explicit declaration is received from a user of a user device. The explicit declaration is configured to influence a subsequent recommendation. The words of the explicit declaration are processed to generate a record. A recommendation rule is generated based on the generated record. The recommendation rule is executed to generate a recommendation for the user. The generated recommendation is provided to the user.

Abstract: In one embodiment, a peristaltic micropump comprising a substrate having a first side and a second side, a microtube that extends across the first side of the substrate, and multiple pump actuators formed on the first side of the substrate and positioned adjacent to the microtube at discrete, spaced positions along the length of the microtube, wherein the micropump is configured to sequentially actuate the pump actuators so as to create peristaltic action that drives fluid contained in the microtube along the length of the tube.

Abstract: Methods, systems, and computer program products are provided that enable users to provide explicit declarations that are used to generate recommendations for the users. An explicit declaration is received from a user of a user device. The explicit declaration is configured to influence a subsequent recommendation. The words of the explicit declaration are processed to generate a record. A recommendation rule is generated based on the generated record. The recommendation rule is executed to generate a recommendation for the user. The generated recommendation is provided to the user.

Abstract: Methods, systems, and computer program products are provided that enable users to provide explicit declarations that are used to generate recommendations for the users. An explicit declaration is received from a user of a user device. The explicit declaration is configured to influence a subsequent recommendation. The words of the explicit declaration are processed to generate a record. A recommendation rule is generated based on the generated record. The recommendation rule is executed to generate a recommendation for the user. The generated recommendation is provided to the user.

Abstract: There is described a food supplement composition comprising a cucumber (Cucumis sativus) extract which in particular reduces the TNF-? level. Raw cucumber extract can inhibit the production of TNF-? in human blood without causing adverse immune reactions. It has therefore been shown that raw cucumber extract can be effectively used as food supplement product or as dietary supplement for a prolonged time for the prevention and treatment of TNF-? level dependant inflammation states.

Abstract: Methods, systems, and computer program products are provided that enable users to provide explicit declarations that are used to generate recommendations for the users. An explicit declaration is received from a user of a user device. The explicit declaration is configured to influence a subsequent recommendation. The words of the explicit declaration are processed to generate a record. A recommendation rule is generated based on the generated record. The recommendation rule is executed to generate a recommendation for the user. The generated recommendation is provided to the user.

Abstract: Described are various compounds, in particular iminosugars, and methods for the treatment of proteostatic diseases, in particular lysosomal storage disorders. The compound may be a pharmacoperone of an enzyme selected from: (a) Acid alpha-glucosidase; (b) Acid beta-glucosidase; (c) glucocerebrosidase; (d) alpha-Galactosidase A; (e) Acid beta-galactosidase; (f) beta-Hexosaminidase A; (g) beta-Hexosaminidase B; (h) Acid sphingomyelinase; (i) Galactocerebrosidase; (j) Acid ceramidase; (k) Arylsulfatase A; (l) alpha-L-Iduronidase; (m) Iduronate-2-sulfatase; (n) Heparan N-sulfatase; (o) alpha-N-Acetylglucosaminidase; (p) Acetyl-CoA: alpha-glucosaminide N-acetyltransferase; (q) N-Acetylglucosamine-6-sulfate sulfatase; (r) N-Acetylgalactosamine-6-sulfate sulfatase; (s) Acid beta-galactosidase; (t) Arylsulfatase B; (u) beta-Glucuronidase; (v) Acid alpha-mannosidase; (w) Acid beta-mannosidase; (x) Acid alpha-L-fucosidase; (y) Sialidase; and (z) alpha-N-acetylgalactosaminidase.

Abstract: Described are various compounds and methods for the treatment of flaviviral infections. In particular, alkaloids and imino sugars in arabinose and/or lyxose stereochemical configuration with antiflaviviral activity are described.

Abstract: Described are various compounds and methods for the treatment of disorders arising from aberrant protein folding, including in particular lysosomal storage diseases. In particular, polyhydroxylated alkaloids and imino sugars which are pharmacoperones of an enzyme and which do not bind to a catalytic site of said enzyme are described.

Abstract: Isolated immunomodulatory (e.g. immunostimulatory) polyhydroxlated pyrrolizidine compounds having the formula are disclosed. In these compounds R is selected from hydrogen, straight or branched, unsubstituted or substituted, saturated or unsaturated acyl, alkyl (e.g. cycloalkyl), alkenyl, alkynyl and aryl groups. The compounds are useful in therapy and prophylaxis, including increasing the Th1:Th2 response ratio, hemorestoration, alleviation of immunosuppression, cytokine stimulation, treatment of proliferative disorders (e.g. cancer), vaccination, stimulation of the innate immune response and boosting of the activity of endogenous NK cells.

Abstract: A method for monitoring the quality of a herbal medicine comprising the steps of: (a) providing a sample of the herbal medicine (b) extracting the sample with a polar solvent to produce a polar extract (c) subjecting the polar extract to ion-exchange chromatography to produce an extract enriched in ionic compounds (d) chromatographically fractionating the enriched extract to yield one or more polar fractions (e) characterizing the polar fractions.

Abstract: A system includes a plurality of distributed refrigeration units respectively coupled to discrete refrigeration circuits. Each refrigeration unit may include a variable compressor, a fixed compressor, a condensing unit, and a controller. The controller compares an operating condition of the refrigeration unit to a refrigeration circuit set point to select a compressor staging capable of achieving the refrigeration circuit set point.

Abstract: A process comprises the steps of: providing a natural (e.g. plant) material; extracting a first sample of the material with a polar solvent to produce a polar extract and a non-polar residue; subjecting the polar extract to ion-exchange chromatography to produce an extract enriched in ionic-compounds and a non-ionic residue; and chromatographically fractionating the enriched extract to yield one or more polar fractions comprising one or more ionic (phyto)chemical(s).

Abstract: A plug assembly for ignition of fuel in admixture with air within a combustion chamber which comprises an exposed heating element having a multi-turn coil of electrically conductive catalytic wire mounted in grooves formed on the surface of ceramic support structure.