Abstract: The present invention relates generally to a drug eluting stent containing metallic surfaces modified in microsphere metallic matrix structure and methods for making same. More specifically, the invention relates to an expandable and implantable vascular stent having at least one matrix layer that promotes improved cellular adhesion properties for healing promotion healing and long term biocompatibility. In the case of coronary stents, the metallic matrix layer promotes re-endothelialization at sites of stent implantation, improves overall healing, and reduces inflammation and intimal disease progression. The microsphere metallic matrix layer may be optionally loaded with one or more therapeutic agent to further improve the function of the implanted stent and further augment clinical efficacy and safety.

Abstract: A stent having cavities has been developed that can be quickly and easily used in a wide variety of situations, that keeps vessels open with a minimum degree of recoil and shortening lengthwise, that is flexible and can be delivered to the most distal lesion, and that can continuously deliver anticoagulant or other biologically active agents for an extended period directly at the site of stent placement. The stent of the present invention includes at least one flexible, serpentine backbone, and a plurality of opposing, outwardly-projecting appendages on said backbone, wherein said stent has a substantially circular cross-section.

Abstract: A catheter formed of an elongated shaft with a dilatation balloon at the distal end includes a guide wire lumen external to the balloon. The guidewire lumen extends from the distal tip of the catheter to a proximal port distal from the proximal end of the catheter. The shaft is formed of a proximal hypotube and a distal spring coil. In some embodiments, the wire lumen extends the full length of the catheter and includes apertures for drug delivery or perfusion. A core wire is included to enhance the pushability of the catheter and support the balloon.

Abstract: A dilatation catheter having a balloon (20) of unique and novel configuration which enhances critical properties of the catheter. In at least one section (26), the balloon (20) has a substantially semi-circular cross section when in an uninflated, unwrapped condition. A groove (28) is formed in the resulting flat surface (30) of the balloon (20) accommodate an elongate guide wire lumen (40) and improves fold memory. The guide wire lumen (40) extends along and beside a distal section (23) of the catheter, and is bonded near its distal end into the groove (28) in the balloon (20). At the distal end of the groove (28), the balloon (20) is configured such that the guide wire lumen (40) passes through the balloon wall, such that the distal end of the lumen is disposed in the interior inflation chamber of the balloon (20). In this way, the guide wire (42) follows an essentially straight path in the region of the balloon (20).