Abstract: A robotic line kitting system is disclosed. In various embodiments, a signal associated with an unsafe condition is received via a communication interface. In response to the signal, a controlled operation to reduce a speed of movement of a robotic instrumentality is performed prior to a safety stop of the robotic instrumentality being triggered.

Abstract: Disclosed herein are compositions including prokaryotic ion channel polypeptides and methods of treating voltage gated ion channel-related condition such as heart arrhythmia, chronic atrial fibrillation, damage from myocardial infarction, damage from stroke, and chronic ischemia.

Abstract: A pharmaceutical vial, container assembly, system and method. The vial can include a hollow body, a first passage, a second passage, a first temporary closure sealing the first passage, and a second temporary closure sealing the second passage. A diluent container can include a first connector to connect the diluent container and vial in fluid communication for mixing an active pharmaceutical ingredient with a diluent. An infusion set can include a second connector to connect the infusion set and vial in fluid communication, and a delivery device. The method can include the steps of connecting the diluent container to the first temporary closure of the vial, transferring a diluent from the diluent container into the vial, reconstituting an active pharmaceutical ingredient with the diluent to form a solution, connecting the delivery device to the second temporary closure, and administering the solution through the delivery device into a patient.

Abstract: This disclosure relates to functionalized polymers and compositions comprising such where the functionalized polymers comprise amide, imide, and/or ester functionalized partially or fully saturated polymer comprising C4-5 olefins having: i) an Mw/Mn of less than 2, ii) a Functionality Distribution (Fd) value of 3.5 or less, and iii) an Mn of 10,000 g/mol or more (GPC-PS) of the polymer prior to functionalization, provided that, if the polymer prior to functionalization is a copolymer of isoprene and butadiene, then the Mn of the copolymer is greater than 25,000 g/mol (GPC-PS).

Abstract: Data indicating a corresponding safety state information indicating an extent to which that operating zone currently is or is not available to the robotic system to perform tasks using one or more robotic instrumentalities associated with a robotic system is used, for each of a plurality of operating zones, to dynamically schedule and perform tasks associated with a higher level objective. The corresponding safety state information associated with the first operating zone indicating one of a plurality of safety states associated with a presence of a human worker in the first operating zone is received from one or more sensors associated with a first operating zone of the plurality of operating zones. Autonomous behavior of the one or more robotic instrumentalities is altered based on the one of the plurality of safety states associated with the presence of the human worker in the first operating zone indicated by the corresponding safety state information.

Abstract: In an example embodiment, an apparatus for making pouch products includes a conveyor system. The conveyor system includes a first receiving location along a path of the conveyor system, and a dosing location along the path of the conveyor system. The apparatus also includes a first material dispensing station configured to transfer a first material to the first receiving location. The first material includes a first elastic layer and a first support layer. The first material dispensing station includes a dispenser roller configured to hold a roll of the first material, a plurality of rollers configured to convey the first material from the dispenser roller to the first receiving location, and a stripper plate configured remove at least a portion of the first support layer from a portion of the first elastic layer.

Abstract: A system and method for facilitating bi-directional authentication between an external device and an implanted medical device (IMD), wherein a therapy application executing on the external device is operative to communicate with the IMD via wireless telemetry communications. Certified security credentials for respective devices may be provisioned with respect to the therapy application. Upon initiating wireless telemetry communications, respective certified security credentials are mutually verified by the external device and the IMD. Responsive to successful verification, a mutual authentication process may be executed between the external device and the IMD using a respective challenge-response sequence.

Abstract: The present invention relates to the development of and use of genetically modified human differentiated cells coupled with xenotransplantation into animal models to identify injury and disease-specific RNA and/or protein biomarkers. Specifically, the present invention encompasses two complementary methods for biomarker discovery that enable the direct and selective labelling, isolation, and analysis of human-specific RNA and/or proteins from xenotransplantation (or chimeric) animal models. Both methods involve the treatment of animal models with an RNA analog and/or amino acid analog that enables the specific isolation and quantification of human RNAs and/or proteins for the identification of novel human biomarkers for a large array of human injuries and diseases.

Abstract: A disk spindle assembly for a hard disk drive includes a hub and a hub flange extending radially from the hub and configured to apply a clamping force to secure disk media to the hub. The hub flange includes multiple protrusions extending from a surface of a top side and configured to contact a disk medium at multiple contact positions in response to application of a clamping load. The protrusions may be annular protrusions circumscribing the hub, where the height of an inner protrusion may be less than the height of an outer protrusion to inhibit coning of the bottom disk medium, and the protrusions may be positioned so that an equivalent contact radius corresponding to contact radii of the inner and outer annular protrusions is at a position halfway between the inner and outer diameters of the disk spacers to inhibit coning of the middle disk media.

Abstract: The eye imaging system for producing images with reduced speckle artifacts may comprise a laser diode for providing a beam of radiation to the eye; a detector for collecting light returning from the eye and generating output signals in response thereto, the detector having a sensor integration time; a driver circuit for applying a modulated drive signal to the laser diode, the modulated drive signal inducing a spectral broadening of the beam of radiation during the sensor integration time. The laser diode may be a single-mode laser designed to operate at a fixed current and wavelength. The drive signal may be modulated by shaping a drive current pulse. The drive signal may be modulated by imposing an RF modulation on a drive current pulse. The drive signal may be further modulated by shaping a drive current pulse.

Abstract: A modular poppet assembly system for a toilet tank flush valve assembly, the modular system comprising a first float portion; and two or more second float portions; wherein, the first float portion is configured to removably attach to each of the two or more second float portions to form two or more poppet assemblies, each of the two or more poppet assemblies comprise a different buoyancy, each of the two or more poppet assemblies allow the toilet tank to fill to substantially a same water volume, and as the poppet assembly buoyancy increases, an increase in flush volume is provided.

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Human Respiratory Syncytial Virus (HRSV) or Human Metapneumovirus (HMPV) inhibitors. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HRSV or HMPV infection. The invention also relates to methods of treating an HRSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract: In an example embodiment, an apparatus for making pouch products includes a conveyor system. The conveyor system includes a first receiving location along a path of the conveyor system, and a dosing location along the path of the conveyor system. The apparatus also includes a first material dispensing station configured to transfer a first material to the first receiving location. The first material includes a first elastic layer and a first support layer. The first material dispensing station includes a dispenser roller configured to hold a roll of the first material, a plurality of rollers configured to convey the first material from the dispenser roller to the first receiving location, and a stripper plate configured remove at least a portion of the first support layer from a portion of the first elastic layer.

Abstract: A method of adjusting core and un-core operating frequencies of two or more processors of a server includes determining core and un-core operating frequency variations versus power consumption limit variations of the two or more processors. The method also includes determining two or more first power consumption levels associated with the two or more processors. Each one of the two or more processors run at essentially a same target core operating frequency and at a same target un-core operating frequency at the respective first power consumption level of the processor. The method further includes adjusting the core and un-core operating frequencies of the two or more processors by setting a power consumption limit of each one of the two or more processors at the respective first power consumption level of the processor.

Abstract: Methods, systems, and apparatuses for audience metric determination are described herein. An audience segment may be targeted for delivery of content. A clustering algorithm may be used to categorize a quantity of users or devices into subsets based on a propensity to consume, present or output a particular type of content, and a quantity of time to output the particular type of content. A weight may be assigned to each subset based on its relevance to other subsets, such as based on data variance, e.g., on a distance to a midpoint of a specific subset of the subsets. An index parameter may be determined for the datasets, e.g., based on each weight for each subset, and data may be generated that reflects a ranking of content delivery spots for delivery of content to the audience segment.

Abstract: Devices, systems, and methods for treating vascular defects are disclosed herein. One aspect of the present technology, for example, includes an occlusive device comprising a mesh having a low-profile state for intravascular delivery to the aneurysm and a deployed state, the mesh comprising a first end portion, a second end portion, and a length extending between the first and second end portions, and a first lateral edge, a second lateral edge, and a width extending between the first and second lateral edges. The mesh may have a predetermined shape in the deployed state in which (a) the mesh is curved along its width, (b) the mesh is curved along its length, and (c) the mesh has an undulating contour across at least a portion of one or both of its length or its width. The mesh is configured to be positioned within the aneurysm in the deployed state such that the mesh extends over the neck of the aneurysm.

Abstract: The application is directed to methods and devices for estimating corrosion of a material. One of the methods includes obtaining data regarding corrosion. The data is obtained from various sources, such as but not limited to sensors and observational data. The data is then trained to provide for a more complete data set. The trained data is then used to estimate the expected amount of corrosion for a given situation.

Abstract: A motion seat is described that includes a chassis, a seat frame, a seat cushion, a backrest, and a resilient hinge. The seat frame is attached to the chassis and the seat cushion and the backrest are each attached to the seat frame. The resilient hinge formed as a unitary body and may be formed from a resilient polymer. The seat cushion and/or the backrest is pivotably attached to the seat frame with the resilient hinge.

Abstract: A circuit for monitoring a circuit payload, includes a plurality of sensors distributed in the circuit, next to the predefined circuit payload; one or more memory units associated with the one or more sensors configured to store sensors' measures made by the one or more associated sensors, every p clock cycles; wherein the circuit is configured to read the sensors' measures stored in at least some of the memory units. Embodiments comprise the use of digital sensors, or analogical sensors coupled with digital converters; the use of FIFO type memory units, adjustments of the depths of the memory units; the use of Finite State Machines configured to cause the circuit to receive sensors' measures; the use of data obfuscation and/or reduction modules; the use of a signature circuit, the use of circuits configured to determine one or more attacks from the sensors' measures.

Abstract: A circuit for a Synthetic Physically Unclonable Function, acronym SPUF, in a computer device, wherein the circuit is configured to receive data from a plurality of hardware sensors and/or actuators accessible in the computer device; to determine deviations in the data; to determine a multivariate distribution of the deviations and to determine an identifier from the multivariate distribution. In described developments, deviations comprise random errors, statistical moments in data originating from sensors and/or actuators amongst accessible ones in the computer device can be selected, and entropy can be maximized. Computer program product embodiments are described.