Patents by Inventor Robert Nicolosi
Robert Nicolosi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220054389Abstract: The embodiment described herein are related nanoemulsions comprising botulinum toxins. In one embodiment, the nanoemulsions are prepared by high pressure microfluidization and comprise a particle size distribution exclusively between 10 and 300 nm. The nanoemulsions contemplated by the present invention are useful for the cosmetic and medical treatment of muscular contracture states. For example, botulinum toxin may relax facial muscles such that skin wrinkles become smoother and less noticeable. Further, the present invention contemplates a cosmetic formulation that may be self-administered, for example, in the privacy of one's home and without medical supervision.Type: ApplicationFiled: March 8, 2021Publication date: February 24, 2022Applicant: University of Massachusetts LowellInventors: Jonathan Edelson, Robert Nicolosi
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Publication number: 20200214961Abstract: The embodiment described herein are related nanoemulsions comprising botulinum toxins. In one embodiment, the nanoemulsions are prepared by high pressure microfluidization and comprise a particle size distribution exclusively between 10 and 300 nm. The nanoemulsions contemplated by the present invention are useful for the cosmetic and medical treatment of muscular contracture states. For example, botulinum toxin may relax facial muscles such that skin wrinkles become smoother and less noticeable. Further, the present invention contemplates a cosmetic formulation that may be self-administered, for example, in the privacy of one's home and without medical supervision.Type: ApplicationFiled: December 13, 2019Publication date: July 9, 2020Inventors: Jonathan Edelson, Robert Nicolosi
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Patent number: 10576034Abstract: The embodiment described herein are related nanoemulsions comprising botulinum toxins. In one embodiment, the nanoemulsions are prepared by high pressure microfluidization and comprise a particle size distribution exclusively between 10 and 300 nm. The nanoemulsions contemplated by the present invention are useful for the cosmetic and medical treatment of muscular contracture states. For example, botulinum toxin may relax facial muscles such that skin wrinkles become smoother and less noticeable. Further, the present invention contemplates a cosmetic formulation that may be self-administered, for example, in the privacy of one's home and without medical supervision.Type: GrantFiled: October 7, 2016Date of Patent: March 3, 2020Assignee: University of Massachusetts LowellInventors: Jonathan Edelson, Robert Nicolosi
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Patent number: 10532019Abstract: The embodiment described herein are related nanoemulsions comprising botulinum toxins. In one embodiment, the nanoemulsions are prepared by high pressure microfluidization and comprise a particle size distribution exclusively between 10 and 300 nm. The nanoemulsions contemplated by the present invention are useful for the cosmetic and medical treatment of muscular contracture states. For example, botulinum toxin may relax facial muscles such that skin wrinkles become smoother and less noticeable. Further, the present invention contemplates a cosmetic formulation that may be self-administered, for example, in the privacy of one's home and without medical supervision.Type: GrantFiled: July 7, 2017Date of Patent: January 14, 2020Assignee: University of Massachusetts LowellInventors: Jonathan Edelson, Robert Nicolosi
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Publication number: 20170312210Abstract: The embodiment described herein are related nanoemulsions comprising botulinum toxins. In one embodiment, the nanoemulsions are prepared by high pressure microfluidization and comprise a particle size distribution exclusively between 10 and 300 nm. The nanoemulsions contemplated by the present invention are useful for the cosmetic and medical treatment of muscular contracture states. For example, botulinum toxin may relax facial muscles such that skin wrinkles become smoother and less noticeable. Further, the present invention contemplates a cosmetic formulation that may be self-administered, for example, in the privacy of one's home and without medical supervision.Type: ApplicationFiled: July 7, 2017Publication date: November 2, 2017Inventors: Jonathan Edelson, Robert Nicolosi
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Publication number: 20170181952Abstract: The embodiment described herein are related nanoemulsions comprising botulinum toxins. In one embodiment, the nanoemulsions are prepared by high pressure microfluidization and comprise a particle size distribution exclusively between 10 and 300 nm. The nanoemulsions contemplated by the present invention are useful for the cosmetic and medical treatment of muscular contracture states. For example, botulinum toxin may relax facial muscles such that skin wrinkles become smoother and less noticeable. Further, the present invention contemplates a cosmetic formulation that may be self-administered, for example, in the privacy of one's home and without medical supervision.Type: ApplicationFiled: October 7, 2016Publication date: June 29, 2017Inventors: Jonathan EDELSON, Robert NICOLOSI
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Patent number: 9486408Abstract: The embodiment described herein are related nanoemulsions comprising botulinum toxins. In one embodiment, the nanoemulsions are prepared by high pressure microfluidization and comprise a particle size distribution exclusively between 10 and 300 nm. The nanoemulsions contemplated by the present invention are useful for the cosmetic and medical treatment of muscular contracture states. For example, botulinum toxin may relax facial muscles such that skin wrinkles become smoother and less noticeable. Further, the present invention contemplates a cosmetic formulation that may be self-administered, for example, in the privacy of one's home and without medical supervision.Type: GrantFiled: October 9, 2012Date of Patent: November 8, 2016Assignee: University of Massachusetts LowellInventors: Jonathan Edelson, Robert Nicolosi
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Publication number: 20150079176Abstract: A uniform microfluidized nanoemulsion is disclosed containing a synergistic combination of two antioxidants and a cell membrane stabilizer phospholipid (i.e., an anti-oxidant synergy formulation; ASF). The microfluidized nanoemulsion improves the combination's cell membrane permeability by at least four-fold over conventional nanoemulsion compositions, which significantly increases the intracellular concentration of typically cell-impermeant antixoidants (i.e., for example, tocopherol) and/or systemic bioavailability. As a nanoemulsion, synergistic combination has greater anticancer efficacy than the same combination applied as a free solution.Type: ApplicationFiled: July 30, 2014Publication date: March 19, 2015Inventors: Robert Nicolosi, Thomas Shea
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Publication number: 20140099342Abstract: The embodiment described herein are related nanoemulsions comprising botulinum toxins. In one embodiment, the nanoemulsions are prepared by high pressure microfluidization and comprise a particle size distribution exclusively between 10 and 300 nm. The nanoemulsions contemplated by the present invention are useful for the cosmetic and medical treatment of muscular contracture states. For example, botulinum toxin may relax facial muscles such that skin wrinkles become smoother and less noticeable. Further, the present invention contemplates a cosmetic formulation that may be self-administered, for example, in the privacy of one's home and without medical supervision.Type: ApplicationFiled: October 9, 2012Publication date: April 10, 2014Applicant: UNIVERSITY OF MASSACHUSETTS LOWELLInventors: Jonathan Edelson, Robert Nicolosi
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Publication number: 20120164182Abstract: The embodiment described herein are related nanoemulsions comprising botulinum toxins. In one embodiment, the nanoemulsions are prepared by high pressure microfluidization and comprise a particle size distribution exclusively between 10 and 300 nm. The nanoemulsions contemplated by the present invention are useful for the cosmetic and medical treatment of muscular contracture states. For example, botulinum toxin may relax facial muscles such that skin wrinkles become smoother and less noticeable. Further, the present invention contemplates a cosmetic formulation that may be self-administered, for example, in the privacy of one's home and without medical supervision.Type: ApplicationFiled: December 1, 2006Publication date: June 28, 2012Inventors: Jonathan Edelson, Robert Nicolosi
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Publication number: 20100183726Abstract: A uniform microfluidized nanoemulsion is disclosed containing an anti-cancer agent, such as dacarbazine. The microfluidized nanoemulsion improves the combination's cell membrane permeability by at least four-fold over conventional nanoemulsion compositions, which significantly increases the intracellular concentration of anti-cancer agents. As a nanoemulsion, dacarbazine has a greater anti-cancer efficacy than when applied as a free solution.Type: ApplicationFiled: August 2, 2007Publication date: July 22, 2010Inventors: Robert Nicolosi, Jean-Bosco Tagne
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Publication number: 20090306198Abstract: A uniform microfluidized nanoemulsion is disclosed containing a synergistic combination of two antioxidants and a cell membrane stabilizer phospholipid (i.e., an anti-oxidant synergy formulation; ASF). The microfluidized nanoemulsion improves the combination's cell membrane permeability by at least four-fold over conventional nanoemulsion compositions, which significantly increases the intracellular concentration of typically cell-impermeant antioxidants (i.e., for example, tocopherol) and/or systemic bioavailability. As a nanoemulsion, synergistic combination has greater anticancer efficacy than the same combination applied as a free solution.Type: ApplicationFiled: September 13, 2006Publication date: December 10, 2009Inventors: Robert Nicolosi, Thomas Shea
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Publication number: 20080274195Abstract: The present invention discloses an improved nanoemulsion comprising a uniform and discrete range of very small particle nano-sized diameters. This uniformity results in improved bioavailability of incorporated compounds (i.e., pharmaceuticals or nutraceuticals) as reflected in various pharmacokinetic parameters including, but not limited to, decreased Tmax, increased Cmax, and increased AUC. The improved method of making these uniform nanoemulsions utilizes microfluidization which differs in both process and mechanics when compared to conventional milling and grinding techniques used to generate nanoparticulate compositions. Further, the improvement results, in part, from a novel step of mixing a substantially soluble compound into a heated dispersion medium. This is unlike current nanoparticulate composition methods that mix an insoluble compound with an unheated dispersion medium. Further, these nanoemulsions are observed to be bacterial-resistant and stable to extremes in both temperature and pH changes.Type: ApplicationFiled: July 11, 2006Publication date: November 6, 2008Applicant: University of Massachusetts LowellInventors: Robert Nicolosi, Thomas Wilson
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Publication number: 20050043312Abstract: Nutriceutical and pharmaceutical formulations for treating neurodegenerative disorders such as Alzheimer's disease are provided. Nutriceutical formulations include two or more of folate, vitamin E, and acetyl-L-carnitine (ALCAR). Pharmaceutical formulations include two or more of 3-deaza-adenosine (DZA), N-acetyl-L-cysteine (NAC), and S-adenosylmethionine (SAM).Type: ApplicationFiled: July 23, 2004Publication date: February 24, 2005Inventors: Thomas Shea, Robert Nicolosi, Eugene Rogers
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Publication number: 20030031724Abstract: Compositions that may be cost-efficiently derived or processed from an emu and used for reducing and/or preventing inflammation in patients are disclosed. The compositions comprise colorless emu oil and/or active components of same in certain proportions. Methods of using said compositions to reduce and/or prevent inflammation in patients and methods of preparing said compositions are also disclosed.Type: ApplicationFiled: May 16, 2001Publication date: February 13, 2003Inventors: Frank Orthoefer, Paul Binford, Robert Nicolosi
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Patent number: 6197357Abstract: A method of producing unsaponifiable rich refined vegetable oils by refining crude vegetable oils with a weak acid salt, e.g., a carbonate salt, to produce a refined vegetable oil and a soapstock is described. The refined oil can be further refined with a strong base to produce unsaponifiable rich concentrates.Type: GrantFiled: May 28, 1998Date of Patent: March 6, 2001Assignee: University of MassachusettsInventors: Carl W. Lawton, Robert Nicolosi, Stephen McCarthy