Abstract: A monolithic gas chromatograph is presented. The monolithic gas chromatograph includes a separation column and a gas detector. The separation column has an inlet to receive a gas sample therein. The separation column resides in a first layer of an integrated chip. The gas detector has an ionization chamber and an ionization source. The ionization chamber has an inlet in fluid communication with an outlet of the separation column to receive a gas sample from the separation column. The ionization source is configured to ionize molecules of the gas sample residing in the ionization chamber. The gas detector resides in a second layer of the integrated chip. The monolithic gas chromatograph further includes a third layer disposed between the first layer and the second layer. The third layer is configured to electrically isolate the first layer from the second layer. The gas detector is fluidly coupled to the separation column.

Abstract: A rapid flow-through, highly sensitive microfluidic photoionization detector (PID) which is micro-fabricated directly onto a substrate, such as a conductive silicon wafer, is provided. The microfluidic PID has an ionization chamber volume of less than 9 ?L. The microfluidic PID may have a flow through design with a microfluidic channel defines a serpentine pattern on the substrate. The flow through design of the microfluidic PID results in negligible dead volume, thus allowing a shortened response time over existing commercially available designs. Such microfluidic PIDs are particularly useful with gas chromatography (GC), including microGC and multi-dimensional microGC systems. Methods for calibrating PIDs are also provided.

Abstract: A rapid flow-through, highly sensitive microfluidic photoionization detector (PID) which is micro-fabricated directly onto a substrate, such as a conductive silicon wafer, is provided. The microfluidic PID has an ionization chamber volume of less than 9 ?L. The microfluidic PID may have a flow through design with a microfluidic channel defines a serpentine pattern on the substrate. The flow through design of the microfluidic PID results in negligible dead volume, thus allowing a shortened response time over existing commercially available designs. Such microfluidic PIDs are particularly useful with gas chromatography (GC), including microGC and multi-dimensional microGC systems. Methods for calibrating PIDs are also provided.