Abstract: CD47+ disease cells such as cancer cells are treated using a combination of CD47 blocking agent and an EGFR antibody such as cetuximab. The anti-cancer effect of cetuximab is enhanced in the presence of SIRP?Fc. Specific combinations include SIRP?Fc forms that comprise an Fc that is either IgGl or preferably IgG4 isotype. These combinations are useful particularly to treat solid tumours and blood cancers including lymphomas, leukemias and myelomas.

Abstract: CD47+ disease cells such as cancer cells are treated using a combination of CD47 blocking agent and a CD38 antibody such as daratumumab. The anti-cancer effect of SIRP?Fc is enhanced in the presence of daratumumab. Specific combinations include SIRP?Fc forms that comprise an Fc that is either IgG1 or IgG4 isotype. These combinations are useful particularly to treat blood cancers including lymphomas, leukemias and myelomas.

Abstract: The present invention relates to isolated polypeptides having lipase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

Abstract: The present invention relates to isolated polypeptides with lipase activity. The invention also relates to polynucleotides encoding the polypeptides; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; compositions comprising the polynucleotides and methods of using the polypeptides or the compositions.

Abstract: One aspect relates to a process for the preparation of a quartz glass body, including providing a silicon dioxide granulate, wherein the silicon dioxide granulate was made from pyrogenic silicon dioxide powder and the silicon dioxide granulate has a BET surface area in a range from 20 to 40 m2/g, making a glass melt out of silicon dioxide granulate in an oven and making a quartz glass body out of at least part of the glass melt. The oven has at least a first and a further chamber connected to one another via a passage. The temperature in the first chamber is lower than the temperature in the further chambers. On aspect relates to a quartz glass body which is obtainable by this process. One aspect relates to a light guide, an illuminant and a formed body, which are each obtainable by further processing of the quartz glass body.

Abstract: Methods for manufacturing a wind turbine rotor blade having a flatback airfoil configuration along at least a portion of a span of the rotor blade include providing a shell mold of the rotor blade. The method also includes laying up an outer skin layer of the rotor blade into the shell mold. Further, the method includes placing at least one pre-fabricated corner of the flatback airfoil configuration into the shell mold. The pre-fabricated corner(s) has a pointed edge. The method also includes infusing the outer skin layer with the pre-fabricated corner(s) to form the flatback airfoil configuration.

Abstract: Methods and systems disclosed provide for visually displaying a graphical representation of two or more print workflows to a user with a Graphical User Interface (GUI), analyzing the two or more print workflows to determine the differences between them, and visually displays the differences to the user with the GUI.

Abstract: One aspect relates to a process for the preparation of a quartz glass body, including providing a silicon dioxide granulate, wherein the silicon dioxide granulate was made from pyrogenic silicon dioxide powder and the silicon dioxide granulate has a BET surface area in a range from 20 to 40 m2/g, making a glass melt out of silicon dioxide granulate in an oven and making a quartz glass body out of at least part of the glass melt. The oven has at least a first and a further chamber connected to one another via a passage. The temperature in the first chamber is lower than the temperature in the further chambers. One aspect relates to a quartz glass body which is obtainable by this process. One aspect relates to a light guide, an illuminant and a formed body, which are each obtainable by further processing of the quartz glass body.

Abstract: Allowing access to regulated content (e.g., FDA regulated) via mobile devices can increase operational efficiency of companies that have this type of content, and allow users to quickly interact with this content even when outside of the company office. Yet, mobile devices present security issues in ensuring that the integrity of the regulated content is maintained. A regulated content management system applies a multi-step validation and authentication process to allow mobile access to regulated content. The system validates a mobile application installed on the device for regulated content access, the mobile device itself, and the credentials of the user trying to access the content before access is granted. This thus provides users with access to regulated content in a mobile environment while maintaining the integrity of the regulated content.

Abstract: CD47+ disease cells, such as various cancers, are treated using a combination of CD47 blockade with T cell checkpoint inhibition. Preferred embodiments use SIRP?Fc in combination with a PD-1 pathway inhibitor such as nivolumab and/or a CTLA-4 inhibitor such as ipilimumab.

Abstract: The invention relates to a process for the preparation of a quartz glass grain comprising the process steps i.) Providing a silicon dioxide granulate from a pyrogenically produced silicon dioxide powder, ii.) Making a glass melt out of silicon dioxide granulate, iii.) Making a quartz glass body out of at least part of the glass melt and iv.) Reducing the size of the quartz glass body to obtain the quartz glass grain. The invention further relates to a quartz glass grain which is obtainable by this process. The invention further relates to opaque quartz glass bodies, which are obtainable by further processing of the quartz glass grain.

Abstract: An electronically-controlled turbocharger (ECT) includes a shaft having a turbine wheel affixed thereto at or adjacent to one end thereof, a retaining feature in the form of a shoulder or a plurality of splines defined radially about the shaft between the turbine wheel and an end of the shaft opposite the one end thereof, a rotor of an electric motor received on the shaft with one end of the rotor facing the turbine wheel configured complementary to and engaging with the retaining feature, and a retaining element affixed to the shaft and abutting the rotor on an end of the rotor opposite the one end thereof.

Abstract: A method of obtaining an elongate carrier (12) to which a plurality of circuits (14) are fixed at their outer portions. The central portions (141) of the circuits are removed while the outer portions remain fixed to the carrier. A circuit (14) is fastened to a carrier (12) where electrical conductors extend from conducting pads of the circuit through holes (121) in the carrier to conducting pads of the carrier on an opposite side of the carrier.

Abstract: Methods and systems of storing and managing regulated content items on a non-regulated storage platform are provided. A representation of a regulated content item representing content of the regulated content item is created. The content of the regulated content item is subject to one or more regulations and the regulated content item is stored on the non-regulated storage platform. The representation of the regulated content item is provided to the non-regulated storage platform for storage. The representation of the regulated content item is configured to be accessible on the non-regulated storage platform. A request to access the regulated content item using the representation of the regulated content item is received. The regulated content item is retrieved from the non-regulated storage platform in response to the received request.

Abstract: A system stores and manages regulated content items on a non-regulated storage platform. The system creates a representation of a regulated content item representing its content that is subject to one or more regulations. The system provides representation of the regulated content item to the non-regulated storage platform for storage. The representation of the regulated content item is configured to be accessible on the non-regulated storage platform. If the system receives a request to access the regulated content item using the representation of the regulated content item, the system retrieves the regulated content item from the non-regulated storage platform to fulfill the request.

Abstract: Methods for manufacturing a wind turbine rotor blade having a flatback airfoil configuration along at least a portion of a span of the rotor blade include providing a shell mold of the rotor blade. The method also includes laying up an outer skin layer of the rotor blade into the shell mold. Further, the method includes placing at least one pre-fabricated corner of the flatback airfoil configuration into the shell mold. The pre-fabricated corner(s) has a pointed edge. The method also includes infusing the outer skin layer with the pre-fabricated corner(s) to form the flatback airfoil configuration.

Abstract: Methods for joining a first blade component and a second blade component of a rotor blade together includes printing and depositing, via a computer numeric control (CNC) device, at least one three-dimensional (3-D) grid structure at a first joint area of the rotor blade. The first joint area contains the first blade component interfacing with the second blade component. The method also includes providing an adhesive at the first joint area to at least partially fill the grid structure. Further, the method includes securing the first blade component and the second blade component together at the first joint area via the adhesive.

Abstract: A method for assembling a shear web assembly of a wind turbine includes providing at least one spar cap. The method also includes forming a spar connecting member of a thermoplastic material via additive manufacturing. Further, the method includes securing the spar connecting member to the spar cap. Moreover, the method includes providing a shear web, forming a web connecting member of a thermoplastic material via additive manufacturing, and securing the web connecting member at a first end of the shear web. In addition, the method includes interconnecting the web connecting member and the spar connecting member at a joint. Thus, the method further includes heating the joint to secure the web connecting member and the spar connecting member together.

Abstract: Methods and systems disclosed provide for visually displaying a graphical representation of two or more print workflows to a user with a Graphical User Interface (GUI), analyzing the two or more print workflows to determine the differences between them, and visually displays the differences to the user with the GUI.

Abstract: CD47+ disease cells such as cancer cells are treated using a combination of CD47 blockade drug and a histone deacetylase (HDAC) inhibitor. The anti-cancer effect of one drug enhances the anti-cancer effect of the other. Specific combinations include SIRP?Fc as CD47 blockade drug, and one of depsipeptide and romidepsin as HDAC inhibitor. These combinations are useful particularly to treat blood cancers including lymphomas, leukemias and myelomas.