Abstract: The present invention relates to an Autotaxin (ATX) inhibitor according to the general formula (I), a pharmaceutical composition comprising said formula (I) and at least one excipient, their use in medicine as well as a process comprising converting compound (II) into compound (III).

Abstract: A system and method are provided for brokering mission critical communication between a sender and a receiver, where the sender provides a message in a first communication medium and the receiver requires or prefers a second communication medium. An interpretation portion reduces the message to essential knowledge data and generates a content descriptive representation, and a routing portion determines a communication media compatibility of the receiver and selectively sets the second communication medium for the message. A mediation portion then adaptively generates a transformed message in the second communication medium so that it is ascertainable to the receiver, and actuates delivery to the receiver. The interpretation portion is trained to identify image objects in an image which are then represented in the content descriptive representation, thereby enabling the mediation portion to generate text or audio content in the transformed message indicating mission critical features within the image content.

Abstract: A system and method are provided for brokering mission critical communication between a sender and a receiver, where the sender provides a message in a first communication medium and the receiver requires or prefers a second communication medium. An interpretation portion reduces the message to essential knowledge data and generates a content descriptive representation, and a routing portion determines a communication media compatibility of the receiver and selectively sets the second communication medium for the message. A mediation portion then adaptively generates a transformed message in the second communication medium so that it is ascertainable to the receiver, and actuates delivery to the receiver. The interpretation portion is trained to identify image objects in an image which are then represented in the content descriptive representation, thereby enabling the mediation portion to generate text or audio content in the transformed message indicating mission critical features within the image content.

Abstract: A system and method are provided for brokering mission critical communication between a sender and a receiver, where the sender provides a message in a first communication medium and the receiver requires or prefers a second communication medium. An interpretation portion reduces the message to essential knowledge data and generates a content descriptive representation, and a routing portion determines a communication media compatibility of the receiver and selectively sets the second communication medium for the message. A mediation portion then adaptively generates a transformed message in the second communication medium so that it is ascertainable to the receiver, and actuates delivery to the receiver. The interpretation portion is trained to identify image objects in an image which are then represented in the content descriptive representation, thereby enabling the mediation portion to generate text or audio content in the transformed message indicating mission critical features within the image content.

Abstract: The invention relates to methods of treating a central nervous system disorder in a subject, comprising reducing the level of LPA in the brain of said subject

Abstract: The invention relates to an organic component emitting white light upward having an electrode (1), a counter electrode (2) constructed in a transparent manner and as a cover electrode and an arrangement of organic layers (3) which is disposed in contact with and between the electrode (1) and the counter electrode (2) and which is configured to emit light when applying an electrical potential to the electrode (1) and the counter electrode (2), a cover layer (6) is applied to a side of the counter electrode (2) facing away from the arrangement of organic layers (3), having a thickness in nanometres within a layer thickness range D as follows: D=d±(0.2×d), wherein d=10.4n2?75n+150 and n is the optical refractive index of the cover layer (6).

Abstract: Lipid phosphate phosphatase proteins, genes coding for them, vectors and cells comprising them, antibodies directed against them, methods of identifying compounds binding to them and functional interactors as well as to the use of proteins, genes, vectors, cells, interacting compounds and functional interactors for treating neuronal diseases and/or injuries.

Abstract: Lipid phosphate phosphatase proteins, genes coding for them, vectors and cells comprising them, antibodies directed against them, methods of identifying compounds binding to them and functional interactors as well as to the use of proteins, genes, vectors, cells, interacting compounds and functional interactors for treating neuronal diseases and/or injuries.