Abstract: The present relates generally to a method for stimulating the activation of an antigen presenting cell. The method includes activating antigen presenting cells by contacting the cells with an effective amount of a GC polymer that has a molecular weight of less than 420 kDa, followed by determining whether the antigen presenting cells are activated by measuring the amount of co-stimulatory marker CD40 expressed by the cells. Also, the present relates to an injectable pharmaceutical composition for stimulating the activation of an antigen presenting cell.

Abstract: The present invention relates generally to therapeutic compositions comprising chitosan-derived compositions used in connection with methods for treating neoplasms, such as for instance, malignant lung, thyroid and kidney neoplasms, and other types of malignant neoplasms, and other medical disorders.

Abstract: The present relates generally to a method for stimulating the activation of an antigen presenting cell. The method includes activating antigen presenting cells by contacting the cells with an effective amount of a GC polymer that has a molecular weight of less than 420 kDa, followed by determining whether the antigen presenting cells are activated by measuring the amount of co-stimulatory marker CD40 expressed by the cells.

Abstract: A single dose material and applicator package that is easily held for removal of a cover and that contains an easily removable applicator. A tray has an applicator well and a material well. Formed in the applicator well is a finger depression adjacent the material well and an applicator support depression adjacent an opposing end of the applicator well. The finger depression permits easy grasping of the tray for removing the cover. The applicator support depression acts as a fulcrum to pivot or lever the applicator out of the tray when a force is applied to one end of the applicator. A material well ramp permits a controlled amount of material to be placed on the applicator brush.

Abstract: A single dose material and applicator package that is easily held for removal of a cover and that contains an easily removable applicator. A tray has an applicator well and a material well. Formed in the applicator well is a finger depression adjacent the material well and an applicator support depression adjacent an opposing end of the applicator well. The finger depression permits easy grasping of the tray for removing the cover. The applicator support depression acts as a fulcrum to pivot or lever the applicator out of the tray when a force is applied to one end of the applicator. A material well ramp permits a controlled amount of material to be placed on the applicator brush.

Abstract: Preparations containing glycated chitosan in a physiologically compatible carrier are described. Viscoelastic preparations comprise 1.0-12.0 percent by weight of glycated chitosan in an aqueous solution while lower viscosity solutions possess 0.1-0.5 percent by weight glycated chitosan. The otherwise free amino groups of the chitosan polymer are preferably 30-90% glycated and possess an average molecular weight of between 100,000 and 2,000,000 Daltons, and, most preferably between 100,000 and 1,000,000 Daltons.

Abstract: Prosthetic devices are prepared for subepithelial implantation by coating their surfaces with a coating comprising crosslinked or uncrosslinked fibronectin. If the surface of the device comprises a material which does not normally bind fibronectin, it is pretreated, for example, by coating with poly(L-lysine). The coated prosthetic device is implanted by removing a portion of the epithelium, affixing the coated device to the subepithelial tissue optionally replacing all or part of the removed epithelium, and allowing new epithelial tissue to grow over and affix itself to the surface of the prosthetic device. The method of the invention can be used to implant contact lenses permanently beneath the epithelium of the cornea.

Abstract: Improved healing of wounds, particularly wounds of the eye, such as keratorefractive surgical incisions, is obtained by coating the wound surfaces with a solution containing a protein crosslinking compound such as dimethyl pimelimidate dihydrochloride, followed by treatment with a composition containing an extracellular matrix material such as fibronectin, a biologically active fragment or an analog thereof.