Abstract: An unmanned aerial vehicle/unmanned aircraft system including an airframe; a plurality of rotor assemblies respectively extending from a plurality of arms connected to said airframe, said rotor assemblies each having a rotor thereon with at least one rotor blade; a landing gear extending from said airframe; and a flight controller disposed on said airframe; wherein said flight controller receives instructions for unmanned aerial vehicle/unmanned aircraft system control.

Abstract: The present invention relates to a reduced scale industrial helicopter, with an integrated automatic flight control system, that includes core autopilot functions, GPS management, and full-function navigation systems. The autopilot technology includes rapid launch capability, real-time in-flight switching between one or more of a) remote control, b) autopilot-directed, c) ground station controlled, and d) home modes, and is upgradeable. The helicopter is used for high or low altitude surveillance, and can handle various payloads, including photographic missions. The helicopter may include onboard batteries and/or a unique battery unit disposed beneath the helicopter, and includes autonomous features such as automatic takeoff, automatic landing, safety return to home base, and predetermined mission plans.

Abstract: An unmanned aerial vehicle/unmanned aircraft system including an airframe; a plurality of rotor assemblies respectively extending from a plurality of arms connected to said airframe, said rotor assemblies each having a rotor thereon with at least one rotor blade; a landing gear extending from said airframe; and a flight controller disposed on said airframe; wherein said flight controller receives instructions for unmanned aerial vehicle/unmanned aircraft system control.

Abstract: The present invention relates to a helicopter having a modular airframe, with multiple layers which can be connected easily, the layers which house the electronics (autopilot and navigation systems), batteries, and payload (including camera system) of the helicopter. The helicopter has four, six, and eight rotors, which can be easily changed via removing one module of the airframe. In one embodiment, the airframe has a vertical stacked appearance, and in another embodiment, a domed shape (where several of the layers are stacked internally). In one embodiment, there is a combination landing gear and camera mount. The helicopter allows for simple flight and usage by remote control, and non-remote control, users.

Abstract: The present invention relates to a helicopter having a modular airframe, with multiple layers which can be connected easily, the layers which house the electronics (autopilot and navigation systems), batteries, and payload (including camera system) of the helicopter. The helicopter has four, six, and eight rotors, which can be easily changed via removing one module of the airframe. In one embodiment, the airframe has a vertical stacked appearance, and in another embodiment, a domed shape (where several of the layers are stacked internally). In one embodiment, there is a combination landing gear and camera mount. The helicopter allows for simple flight and usage by remote control, and non-remote control, users.

Abstract: The present invention relates to a reduced scale industrial helicopter, with an integrated automatic flight control system, that includes core autopilot functions, GPS management, and full-function navigation systems. The autopilot technology includes rapid launch capability, real-time in-flight switching between one or more of a) remote control, b) autopilot-directed, c) ground station controlled, and d) home modes, and is upgradeable. The helicopter is used for high or low altitude surveillance, and can handle various payloads, including photographic missions. The helicopter may include onboard batteries and/or a unique battery unit disposed beneath the helicopter, and includes autonomous features such as automatic takeoff, automatic landing, safety return to home base, and predetermined mission plans.

Abstract: An interactive display system comprises a white board which communicates with a PC. A projector receives signals from the PC which are translated into corresponding project image which is projected on to the white board. The image projected on to the white board is the same as that shown on a computer screen. By using an electronic pen the position of which can be detected electronically by means of a plurality of wires embedded beneath the surface of the white board and using methods already known in the art, the electronic pen can function in the same way as a computer mouse. The image projected on to the white board may also be manipulated by means of a remote control device, which uses Infra red communication to transmit signals to a transponder built within the white board.

Abstract: An interactive display system comprises a white board which communicates with a PC. A projector receives signals from the PC which are translated into corresponding projection image which is projected on to the white board. The image projected on to the white board is the same as that shown on a computer screen. By using an electronic pen the position of which can be detected electronically by means of a plurality of wires embedded beneath the surface of the white board and using methods already known in the art, the electronic pen can function the same way as a computer mouse. The image projected on to the white board may also be manipulated by means of a remote control device, which uses infra red communication to transmit signals to a transponder built within the white board.

Abstract: Isoquinoline compounds with G are provided that influence, inhibit or reduce the action of a G-protein receptor kinase. Pharmaceutical compositions including therapeutically effective amounts of the isoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, osteoporosis and glaucoma are also provided.

Abstract: Hydrazide compounds with GPCR desensitization inhibitory activity are provided that may be used to influence, inhibit or reduce the action of a G-protein receptor kinase. Pharmaceutical compositions including therapeutically effective amounts of the hydrazide compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions controlled or influenced by GPCRs are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, osteoporosis and glaucoma are also provided.

Abstract: A universal controller for an automatic door system including a door carried on a frame for movement along a predetermined path of movement between open and closed positions. The universal controller includes a housing for mounting the controller in a stationary position relative to the door frame and an assembly including a processor carried by the housing for processing data operatively received from a plurality of sensors and relating to the operation of the movable door. The processor is configured to generate operational values which are transmitted to and control a drive motor used to move the door between the open and closed positions. The assembly further includes an arrangement for adjusting the operational values generated by the processor and transmitted to the drive motor. A modular harness connects the controller to the drive motor and to the sensors.

Abstract: A mixing system includes a housing and a motor mount disposed on the housing and having a passage extending therethrough. A dive motor is coupled with the motor mount for selectively rotating the motor mount relative to the housing. A rotational assembly includes a hub having a passageway extending therethrough and a casing at least partially encircling the hub, the hub being rotatable to the casing. The rotational assembly is removably coupled to the housing so that the passageway of the hub aligns with the passage of the motor mount.

Abstract: The present invention relates to methods of treating disease by altering G protein coupled receptor kinase (GRK) 6. This may be done by altering the expression or activity of the protein, for example. The present invention may be used for disease diagnosis, by detecting the expression or activity of GRK6. The present invention relates to a GRK6 deficient mouse, GRK6 splice variants, and methods of use. The present invention also relates to methods of identifying compounds that alter GRK6 activity. The present invention relates to disease treatment by altering GRK6 expression or activity.

Abstract: The present invention relates to a stirred-tank reactor system and methods of preparing such systems. The present invention further encompasses the use of the stirred-tank reactor system as a disposable bioreactor and in kits with disposable elements.

Abstract: The present invention relates to a stirred-tank reactor system and methods of preparing such systems. The present invention further encompasses the use of the stirred-tank reactor system as a disposable bioreactor and in kits with disposable elements.

Abstract: Methods of detecting G protein-coupled receptor (GPCR) activity in vitro and in vivo are provided. In one embodiment, the method includes providing at least one cell that expresses a GPCR and a plurality of conjugated proteins. Each of the plurality of conjugated proteins is formed by conjugating an arrestin protein and a detectable molecule. The plurality of conjugated proteins are substantially evenly distributed in the cytoplasm of the at least one cell. A first image of the at least one cell is obtained by detecting an amount of energy emitted from the detectable molecules and storing a value relative to the amount of energy. The at least one cell is treated with an agonist. A second image of the at least one cell is obtained. The first image and the second image are compared to detect the localization of at least some of the plurality of conjugated proteins at endocytic vesicles and/or endosomes.

Abstract: The methods of the present invention allow the screening of a test composition for non-receptor-specific GPCR desensitization inhibitory activity. The methods involve screening a test composition for an indication of GPCR desensitization inhibitory activity against two or more GPCRs that are different from each other. When there is an indication that a particular test composition has GPCR desensitization inhibitory activity with respect to each of the two or more GPCRs that are different from one another, then, according to the present invention, there is an indication that the test composition has non-receptor-specific GPCR desensitization inhibitory activity.

Abstract: The present invention relates to modified G-protein coupled receptors (GPCRs). The modified GPCRs of the present invention include GPCRs that have been modified to have carboxyl terminal tails comprising one or more sites of phosphorylation, preferably one or more clusters of phosphorylation sites. The modified GPCRs of the present invention may comprise a retained portion of a carboxyl-terminus region from a first GPCR fused to a polypeptide, wherein the polypeptide comprises the one or more clusters of phosphorylation. The present invention also relates to methods of screening compounds and sample solutions for GPCR activity using the modified GPCRS.

Abstract: A monitor includes cardiac and movement sensors 36, 34 responsive to a user's heart beat and a user's movement. The monitor includes a processor coupled to the sensors for generating heart-rate or other cardiac data and user movement or activity data. These data can be stored in a memory and used to analyse the relationship between heart rate and physical exertion.

Abstract: The present invention relates to agonist-independent methods of screening for compounds that alter GPCR desensitization. Included in the present invention are cell lines containing GRKs, in which GPCRs are desensitized in the absence of agonist; the GRKs may be modified. The present invention relates to methods to determine if a GPCR is expressed at the plasma membrane, and if the GPCR has an affinity for arrestin. Modified GPCRs which have increased arrestin affinity are included in the present invention. These modified GPCRs are useful in methods to screen for compounds that alter desensitization, including both the agonist-independent methods and agonist-dependent methods described herein.