Abstract: The invention relates to macerator for processing a slurry, the macerator comprising an inlet configured to receive a flow of inlet slurry comprising particles having an average particle size of less than 20 mm, an outlet, two or more bodies that rotate relative to each other, each body comprising a plurality of apertures to define a flow path through each body, wherein the slurry traverses the flow path from the macerator inlet to the macerator outlet via the at least one aperture of each body to produce an outlet slurry.

Abstract: One embodiment of the present invention sets forth a method of selecting an entry in a database in an in-vehicle infotainment system. The method includes receiving a second single-character input after receiving a first single-character input, generating a multi-character search string in which the first character of the multi-character search string is the first single-character input and the second character of the multi-character search string is the second single-character input, searching a database stored in the in-vehicle infotainment system for entries that match the multi-character search string, and causing a number of entries that match the multi-character search string to be displayed by the in-vehicle infotainment system. An advantage of the disclosed embodiment is that a vehicle operator can effectively search through a large number of entries in an in-vehicle system with reduced distraction and without stopping the vehicle.

Abstract: A bone fragment and osteomedullary tissue harvesting system that includes a harvesting device, a collection vessel and tubing. The harvesting device includes a needle portion and a handle portion. The needle portion that has a needle bore that extends through at least part of the needle portion. The handle portion is operably attached to the needle portion. The handle portion includes a connection port and a vacuum control mechanism that are in communication with a handle bore that extends through the handle portion. The needle bore is in communication with the handle bore. The vacuum control mechanism includes a vacuum aperture that extends through a surface of the handle portion and is in communication with the handle bore. The collection vessel is capable of receiving aspirated bone fragments and tissue. The tubing operably connects the connection port and the collection vessel.

Abstract: Implementations relate to systems and methods for generating a user profile based on periodic location fixes. A cellular telephone or other mobile device captures location information via GPS or other capability. A location history can be generated from accumulated location fixes. The location history is then analyzed to detect the user's travel and dwell patterns. That information can be combined with business classification (e.g., SIC, etc.) or Point of Interest (POI) databases to identify a user's likely home, work, or other locations based on dwell-times, time of day, and other parameters. The user's age and gender can potentially be inferred based on types of locations visited, such as school locations. The user profile can be correlated with market segmentation databases to generate a marketing rating, such as a Nielsen or Claritas rating. Advertising, media, or other content can then be tailored to the user's individual location and demographic profiles.

Abstract: A braiding machine comprising a support structure, a track, an enclosure, a plurality of rotor metals, and a passageway having a first opening and a second opening, and a method of forming an upper using a braiding machine, the method comprising braiding over a forming last that passes from a first side of a braiding point to a second side of the braiding point of the braiding machine. The braiding machine is capable of forming intricate braided structures and may include different sized rings and non-linear passageways through which a forming last passes. Multiple forming lasts may be attached together by connection mechanisms and passed through the braiding machine.

Abstract: A side-deliverable prosthetic heart valve includes an outer frame and a flow control component. The outer frame has a supra-annular region, a subannular region, and a transannular region therebetween. The flow control component is mounted to the outer frame such that at least a portion of the flow control component is disposed in the transannular region. The prosthetic valve has a delivery configuration for side-delivery via a delivery catheter and is expandable when the prosthetic valve is released from the delivery catheter. The subannular region of the outer frame is disposable in a first configuration as the prosthetic valve is seated in an annulus of a native heart valve and is transitionable to a second configuration after the prosthetic valve is seated in the annulus of the native heart valve.

Abstract: A method of forming a handle for an oral care implement. The method may include first forming a core structure out of a first hard plastic. Next, an elongated handle body may be formed out of a second hard plastic, whereby during formation the elongated handle body is made to partially surround the core structure, while leaving opposing surfaces of the core structure exposed. Finally, a grip cover may be formed out of a resilient material and positioned over at least a portion of the elongated handle body. The oral care implement handle formed by the method may include a handle having an elongated handle body and a core structure. The elongated handle body may have openings in opposing surfaces. The core structure may be partially surrounded by the elongated handle body while protruding from the openings.

Abstract: The present invention relates to methods of treating patients with advanced forms of cancer, such as unresectable or metastatic renal cell carcinoma or kidney cancer, in which X4P-001 or a pharmaceutically acceptable salt thereof is administered as monotherapy or in combination with an immune checkpoint inhibitor, such as nivolumab. The methods demonstrate surprising results, including regression of disease, with comparatively little toxicity.

Abstract: Methods and systems are provided for independently removing streak artifacts and noise from medical images, using trained deep neural networks. In one embodiment, streak artifacts and noise may be selectively and independently removed from a medical image by receiving the medical image comprising streak artifacts and noise, mapping the medical image to a streak residual and a noise residual using the trained deep neural network, subtracting the streak residual from the medical image to a first extent, and subtracting the noise residual from the medical image to a second extent, to produce a de-noised medical image, and displaying the de-noised medical image via a display device.

Abstract: Processes for making bicyclic compounds and precursors thereof, and particularly for making [1.1.1]propellane and bicyclo[1.1.1]pentane and derivatives thereof, utilize continuous flow reaction methods and conditions. A continuous process for making [1.1.1]propellane can be conducted under reaction conditions that advantageously minimize clogging of a continuous flow reactor. A continuous flow process can be used to make precursors of [1.1.1]propellane.

Abstract: A method and apparatus is disclosed, which improves the analysis of an object within a scanned bag. Specifically, the techniques disclosed herein overcome the problem of measurement errors due to imaging artifacts, which can occur during imaging examinations like CT scans. This process also discloses a method of using an improved accuracy of data units of an object lead to more accurate classification of the material that makes up the object.

Abstract: The disclosure provides a manifold comprising a trailer and a piping system. The piping system is disposed on top of the trailer, wherein the piping system comprises a first set of conduits and a second set of conduits. Each of the first set of conduits and the second set of conduits comprises a first line comprising an inlet disposed at a first side of the trailer and a second line comprising an inlet disposed at the first side of the trailer, wherein the first line is disposed above the second line. There is a plurality of outlets and a plurality of valves disposed along the second line.

Abstract: A light-emitting device includes a lens of refractive index n having a spherical exit surface of radius R and a luminous element positioned such that at least a portion of an edge of an emitting surface of the luminous element lies on a sphere of radius R/n opposite the exit surface, whereby that portion of the edge of the emitting surface is aplanatically imaged by the spherical exit surface. The light-emitting device may further include one or more reflective sidewalls arranged to reflect a fraction of light emitted from the luminous element before it is refracted by the exit surface. A luminaire incorporating a housing and a light-emitting device of this type is also provided, which may include one or more additional optical elements such as reflectors or lenses to further direct and shape light from the light-emitting device.

Abstract: A heat shield for an aircraft. The heat shield comprises a lower skin configured to be exposed to exhaust heat of a jet engine, and side skins that are indirectly joined to the lower skin.

Abstract: A controllable lighting device may utilize a controllable impedance circuit to conduct a load current through an LED light source. The controllable impedance circuit may be coupled in series with a first switching device, which may be rendered conductive and non-conductive via a pulse-width modulated signal to adjust an average magnitude of the load current. The controllable lighting device may further comprise a control loop circuit that includes a second switching device. The second switching device may be rendered conductive and non-conductive in coordination with the first switching device to control when a feedback signal is provided to the control loop circuit and used to control the LED light source. The control loop circuit may be characterized by a time constant that is significantly greater than an operating period of the load current.

Abstract: A catheter has a guide-tip including at least one wing for crossing a CTO lesion in an artery via exploring the subintimal space. The catheter can includes one or more exit port(s) and radiopaque marker(s) for steering a re-entry wire through one of the exit ports. The catheter may include a number of spiral-cut sections with varying characteristics to provide different strength and flexibility along the axial direction.

Abstract: The present disclosure relates to an exercise apparatus. More particularly, the present disclosure relates to an apparatus operated by hand which comprises a base upon which extend frame supports for the seat unit, resistance unit, crank unit, and guide unit. Embodiments provide for a crank to be mounted to the base and frame and wherein the crank is connected to first and second actuating rods via a coupling. The actuating rods are slidably connected at one end via a guide pivotally mounted to the frame and have a free end for a user to grip.

Abstract: The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

Abstract: The present disclosure relates to electroactive materials for use in electrodes of lithium-ion electrochemical cells and methods of making the same, for example, methods for lithiating electroactive materials. A method of lithiating an electroactive material may include dispersing an electroactive material precursor within a room-temperature electrolyte that includes a lithium-based salt and contacting the electrolyte mixture and a lithium source so as to cause the lithium source to ionize and form lithium ions. The lithium ions may react with the electroactive material precursor to form a fully lithiated electroactive material (e.g., greater than 70% of total lithiation). The method further includes, in certain aspects, electrochemically discharging the fully lithiated electroactive material to form a lithiated electroactive material having an optimized lithiation state (e.g., less than or equal to about 40% of a first lithiation state of the fully lithiated electroactive material).