Abstract: Efforts to use RNA-cleaving DIMA enzymes (DNAzymes) as gene silencing agents in therapeutic applications have stalled due to their low efficacy in clinical trials. Here the present invention reports a xeno-nucleic acid (XNA) modified version of the classic DNAzyme 10-23 that achieves multiple turnover activity under cellular conditions and resists nuclease digestion. The new reagent overcomes the problem of product inhibition limiting previous 10-23 designs using molecular chemotypes with DNA. FANA, and TNA backbone architectures that balance the effects of enhanced biological stability with RNA hybridization and divalent metal ion coordination. In cultured mammalian cells. X 10-23 facilitates persistent gene silencing by efficiently degrading exogenous and endogenous mRNA transcripts. Together, these results demonstrate that new molecular chemotypes can improve the activity and stability of DNAzymes, and may provide a new route for nucleic acid enzymes to reach the clinic.

Abstract: Embodiments herein disclose, for example, a method performed by a radio network node for communicating or handling communication in a wireless communication network. The radio network node transmits an indication requesting a UE to perform a measurement of a call setup time for the UE in the wireless communication network and/or to provide a value of the measurement to the radio network node.

Abstract: A membrane-assisted process for the preparation of defined monomer sequence polymers, including oligonucleotides and peptides, in solution phase is described. The growing defined monomer sequence polymer is attached to a soluble synthesis support having properties that allow the polymer to be straightforwardly prepared in certain industry-favoured solvents with improved membrane flux and reduced fouling.

Abstract: A device for production of heavy metal powders by ultrasonic atomization from a heavy metal raw material is provided. The device comprises a feeding means, a heat source, an adjusting means, and a collecting means. The feeding provides the heavy metal raw material in the vicinity of the heat source, and the heat source generates an electric arc to heat the heavy metal raw material to create a molten metal pool on a sonotrode. The sonotrode provides ultrasonic mechanical vibrations to the molten metal pool to cause heavy metal droplets to be ejected from the molten metal pool. The adjusting means adjusts the feeding means, the heating means, and the sonotrode to direct the heavy metal droplets to cause the heavy metal droplets to freely cool down within a predetermined distance and transform the heavy metal droplets to the heavy metal powder.

Abstract: Described herein are compositions comprising recombinant viral vectors, e.g., recombinant retroviral vectors, for delivering a therapeutic or a vaccine. The recombinant retroviral vectors described herein are modified for safer application of therapeutic or vaccine delivery. Also described herein are methods for using the compositions comprising recombinant viral vectors for delivering a therapeutic or a vaccine.

Abstract: Disclosed are devices and methods for improving healing of an enthesis. An effective amount of a composition comprising one or more sex steroids and/or sex steroid equivalents is locally administered at the site of a repaired enthesis. The composition causes upregulation of one or more chondrogenic, angiogenic, and/or tendon modulation genes, resulting in improved healing of the enthesis. The improved enthesis healing occurs even where the subject has normal levels of sex hormones.

Abstract: A computer-implemented method for managing computational cluster access to multiple domains includes generating, using a ticket-based computer network authentication protocol, a primary set of keys based on remote system access credentials for a primary domain and a secondary set of keys based on remote system access credentials for a secondary domain. The method includes merging the primary set of keys with the secondary set of keys to form a merged set of keys. The method further includes activating a system daemon to provide access to the primary domain and the secondary domain by a computational cluster based on the merged set of keys. The method further includes connecting, using the ticket-based computer network authentication protocol via the system daemon, a remote computing device of the primary domain and a remote computing device of the secondary domain to the computational cluster.

Abstract: A system and method of order fulfilment is described. The system comprises a storage and retrieval system, a transfer system and at least one pick station. The transfer system further comprises conveyance means disposed between the storage and retrieval system and the pick station such that items delivered to the transfer system from the storage and retrieval system may be conveyed to the pick stations independently of the normal operation of the pick station.

Abstract: A method of installing a modular workbench system in a laboratory comprising installing a workbench having a work surface accessible to a user from a free side for user manipulation of objects on the work surface such that the side opposite to the free side is installed against an object. A robotic arm is mounted on the free side and has at last least three degrees of freedom to manipulate objects on the work surface. The workbench may comprise a rail extending along the free side to slidably support the robotic arm. The workbench may have a transport surface with a magnetic conveyor system to transport objects at a level below the work surface.

Abstract: A method of assessing latency in a communications network comprising attempting to contact from a UE in a cellular network a specific internet resource with a HTTP request addressed to the resource and capturing data specifying the period between making the attempt and receiving at the UE from the resource a response to the request. Thus, data can be obtained from which can be made an end-to-end measurement of the latency affecting a user of a UE. Such measurements can be used by the operator of the communications network to, amongst other things, assess whether the network is performing satisfactorily, to advise users about the performance of the network and, determine that hardware or software within the network needs repair, upgrade, or augmentation.

Abstract: Presented are systems, methods, and devices for provisioning sample support, controlled liquid deposition, and/or desired sample thicknesses during cryo-electron microscopy processes. A sample support for a cryo-electron microscopy process includes a support grid with multiple grid faces. The grid may be substantially rigid, flat and circular, may have a diameter of between about 2.9 and 3.1 mm, and may have a thickness of about 10 to 25 ?m. A foil covers at least one of the grid faces and includes multiple foil regions that each has a distinct thickness. The foil may be a thin and flexible metal or carbon foil. At least one of the foil regions contains an array of through-holes. A boundary between the foil regions with distinct thicknesses forms a step edge that pins thereto a receding contact line of a liquid drop deposited on the foil.

Abstract: The present disclosure relates to chain monitoring systems and methods. In particular, the chain monitoring system is configured to mount onto a portion of a chain and measure one or more parameters associated with one or more characteristics of the chain. The measured parameters are processed by the chain monitoring system and/or transmitted to a remote system for analysis. The analysis may be used to determine a characteristic and/or change in the characteristic of the chain. In some examples, the characteristic is an elongation value associated with the chain, which can be transmitted to a networked system for analysis, display, and/or control. In some examples, a sensor can be employed to measure one or more characteristics of the chain. The sensor may include, but is not limited to, a strain gauge, an accelerometer, an optical, a sonic, and/or a magnetic sensor.

Abstract: New liposome formulations for pesticide delivery and methods for producing and using the same are provided. The present disclosure describes methods of making liposomes that encapsulate insecticidal proteins, and the use of the same to control or inhibit pests. Also described are liposome compositions and formulations comprising insecticidal proteins, and methods regarding the same to protect plants and animals from pests.

Abstract: A decontamination facility for personnel and personal protective equipment (PPE) is disclosed. The decontamination facility comprises shipping containers that includes: decontamination and laundering equipment, one or more personnel showers, doors, a heating, ventilation and air conditioning (HVAC) system, a hot water heater, and a riser system. The doors are sized to allow the decontamination and laundering equipment to pass through easily. The heating, ventilation and air conditioning (HVAC) system is configured to provide a clean, climate-controlled, atmosphere inside the container. A riser system can be attached to the bottom of one or more corner supports to create a crawl space beneath the container, and the crawl space houses a wastewater collection and removal system, a tank, and an ejector pump to push wastewater to a sewer or septic system.

Abstract: Systems and methods of the present disclosure are directed toward digital signal processing using machine-learned differentiable digital signal processors. For example, embodiments of the present disclosure may include differentiable digital signal processors within the training loop of a machine-learned model (e.g., for gradient-based training). Advantageously, systems and methods of the present disclosure provide high quality signal processing using smaller models than prior systems, thereby reducing energy costs (e.g., storage and/or processing costs) associated with performing digital signal processing.

Abstract: A method for producing a component includes providing a powder or a wire where the powder or the wire is formed from an aluminum alloy of 12% by weight to 40% by weight silicon, 0.3% by weight to 4% by weight copper, 0.2% by weight to 0.7% by weight magnesium, at most 1% by weight iron, at most 0.5% by weight zirconium, and a remainder of aluminum and further accompanying elements and/or production-related impurities that each have a mass fraction of at most 0.3 percent individually and that in total have a mass fraction of at most 1.5 percent. The method further includes producing at least a sub-region of the component from the powder or the wire by an additive manufacturing process.

Abstract: A method and apparatus are provided for gathering analytics. In an embodiment, a method includes monitoring interactions of multiple users related to at least one of: multiple base content and multiple supplemental content. The supplemental content is associated with one or more products or services identified in the base content. The method also includes obtaining interaction information associated with the interactions. The method also includes selecting specified supplemental content to present to a specified user based on (i) the interaction information and (ii) specified base content presented to the specified user. The method also includes sending the specified base content and the specified supplemental content to an endpoint associated with the specified user.

Abstract: Disclosed herein is a method for calibrating a spectrometer device. The spectrometer device includes at least one detector device including at least one optical element configured for separating incident light into a spectrum of constituent wavelength components and further includes a plurality of photosensitive elements. The method includes the following steps: a) illuminating, by using at least one broadband light source, the spectrometer device through at least one optical interferometer; b) determining for the plurality of photosensitive elements a plurality of detectors signals depending on the illumination through the optical interferometer in step a); and c) determining at least one item of calibration information from the plurality of detector signals. Further disclosed herein are a system for calibrating a spectrometer device, a computer program and a computer-readable storage medium for performing the method.

Abstract: A method for controlling an Air Handling Unit (AHU) of an HVAC (Heating, Ventilating and Air Conditioning) system servicing a building space of a building includes determining when there is an elevated pathogen transmission risk in the building space. In response to determining that there is an elevated pathogen transmission risk in the building space, the AHU is controlled to adjust operation of the AHU to alleviate the elevated pathogen transmission risk.

Abstract: A downspout extension assembly includes an elbow having a first tubular body, an inlet and an outlet, the outlet at an angle of less than 180 degrees relative to the inlet, and a pair of connectors integrally formed with the first tubular body, positioned on opposite sides of the elbow's outlet. A downspout extension comprises a second tubular body having first and second ends. The first end includes a cutout in an upper wall of the second tubular body and a pair of apertures corresponding to the elbow's connectors. The elbow and the downspout extension are each manufactured of a semi-rigid, resilient material. The downspout extension is releasably mounted to the elbow by inserting a free end of each elbow connector through a corresponding aperture of the downspout extension to rotatably mount the downspout extension to the elbow. The downspout extension rotates between a storage position and a deployed position.