Abstract: The present disclosure provides pharmaceutical compositions of niclosamide that may be administered either orally or by inhalation. These compositions may allow the achievement of a therapeutically effective dose of niclosamide to the lungs or the gastrointestinal tract. These compositions may be used to treat one or more diseases or disorders such as a viral infection or cancer.

Abstract: A brush with a top member having a first exterior surface, a first interior surface, and a plurality of first bristles extending from the first interior surface. The brush having a second member connected to the first member, the second member having a second exterior surface, a second interior surface, and a plurality of second bristles extending from the second interior surface. The first member and the second member are moveable relative to one another between a closed position in which the plurality of first bristles and the plurality of second bristles define an at least substantially cylindrical space there between, and an open position in which a gap defined by the space between the first member and the second member is larger than when the first member and the second member are in a closed position.

Abstract: Curcumin analogues and methods are provided for treatment of disease.

Abstract: Curcumin analogues and methods are provided for treatment of disease.

Abstract: Curcumin analogues and methods are provided for treatment of disease.

Abstract: Curcumin analogs and methods are provided for treatment of disease.

Abstract: Security systems, such as in a home or other building, periodically transmit status data to a remote facility so that the remote facility is continuously informed of the security systems' status. A user interface device at one security system, or a web browser at a personal computer, can obtain information regarding, or provide commands to, one or more other security systems at remote locations by communicating with the remote facility. The remote facility also reports specified events, such as alarms, that occur at a security system to one or more other security systems. Other information, such as video and audio data from a security system, can also be provided to the remote facility for sharing with other security systems. An intercom feature can also be established via the remote facility.

Abstract: A method for assembling a gas turbine engine includes providing a core gas turbine engine including a high-pressure compressor, a combustor, and a turbine, and coupling a counter-rotating fan assembly to the core gas turbine engine such that air discharged from the counter-rotating fan assembly is channeled directly into an inlet of the gas turbine engine compressor.

Abstract: A method and system for maintaining a limiting gas temperature in a gas turbine engine working fluid flowpath by monitoring the gas temperature and adjusting one or more parameters when the gas temperature exceeds a predetermined or a calculated temperature limit during engine operation. The parameters include one or more of a group of engine parameters including high and low pressure turbine nozzle flow areas, fan and core flow areas, and a rotor speed. The one or more parameters are adjusted to lower the gas temperature to below the temperature limit during engine operation. The limiting gas temperature may be a turbine exhaust gas temperature such as a high pressure turbine exhaust gas temperature. The turbine nozzle flow areas may be adjusted with variable nozzle vanes and the fan and core exhaust nozzle flow areas with a translatable fan nozzle cowling and a translatable core nozzle plug, respectively.

Abstract: A method for assembling a gas turbine engine includes providing a core gas turbine engine including a high-pressure compressor, a combustor, and a turbine, coupling a counter-rotating fan assembly to the core gas turbine engine such that air discharged from the counter-rotating fan assembly is channeled directly into an inlet of the gas turbine engine compressor, and coupling a counter-rotating low-pressure turbine assembly to the counter-rotating fan assembly.

Abstract: A gas turbine engine combustion system includes a plurality of fuel injectors circumferentially disposed around a combustor in a one to one fuel supply relationship with a plurality of fuel nozzle valves, and an electronic controller for controlling the fuel nozzle valves to eliminate and/or reduce hot streaking in response to sensed hot streak conditions. The fuel nozzle valves may be modulating valves. The electronic controller may be used to individually control the fuel nozzle valves. The hot streak conditions may be sensed with temperature sensors such as temperature sensors operably mounted in the combustor. A program in the electronic controller may be used for determining broken or malfunctioning sensors by calculating a combustor temperature and comparing it to measured temperatures from the sensors and comparing the measured fuel pressures in the individual fuel nozzle circuits with the simulated or calculated fuel pressures.

Abstract: A gearbox includes a support structure, at least one sun gear coupled within the support structure, and a plurality of planetary gears coupled within the support structure. The support structure includes a first portion, an axially aft second portion, and a thrust spring coupled between the first and second portions.

Abstract: A method for assembling a gas turbine engine includes coupling a low-pressure turbine to a core turbine engine, coupling a gearbox to the low-pressure turbine, coupling a first fan assembly to the gearbox such that the first fan assembly rotates in a first direction, and coupling a mechanical fuse between the first fan assembly and the low-pressure turbine such that the mechanical fuse fails at a predetermined moment load.

Abstract: A method facilitates assembling a gas turbine engine. The method comprises coupling a low-pressure turbine rotatable about a drive shaft to a counter-rotating fan assembly including a first fan assembly and a second fan assembly wherein the first fan assembly rotates in a first direction and the second fan assembly rotates in an opposite second direction. The method also comprises coupling a planetary gearbox substantially circumferentially about the drive shaft such that an input of the gearbox is coupled to the low-pressure turbine and an output of the gearbox is coupled to the counter-rotating fan assembly, and such that the gearbox is positioned within a lubrication fluid sump that substantially circumscribes the gearbox.

Abstract: A method for assembling a gas turbine engine includes coupling a gearbox to a low-pressure turbine, the gearbox includes a plurality of planetary gears intermeshed with the sun gear, each of the planetary gears includes a first gear portion having a first diameter and a second gear portion having a second diameter that is different than the first diameter.

Abstract: A method for assembling a gas turbine engine including providing a core gas turbine engine at least partially defined by a frame. The gas turbine engine has a drive shaft that is rotatable about a longitudinal axis of the core gas turbine engine. A counter-rotating fan assembly is coupled to the low-pressure turbine. The counter-rotating fan includes a first fan assembly that rotates in a first direction and a second fan assembly that rotates in an opposite second direction. A booster compressor is coupled to the second fan assembly. A first bearing assembly is mounted between the drive shaft and the frame and operatively coupled to the first fan assembly to transmit thrust force from the first fan assembly to the frame. A second bearing assembly is mounted with respect to the second fan assembly and operatively coupled to the second fan assembly to transfer thrust force from at least one of the second fan assembly and the booster compressor to the second bearing assembly.

Abstract: A method for assembling a gas turbine engine includes coupling a low-pressure turbine to a core turbine engine, coupling a gearbox including an input, a first output, and a second output, to the low-pressure turbine, coupling a first fan assembly to the gearbox first output, and coupling a second fan assembly to the gearbox second output.

Abstract: A method for assembling a gas turbine engine including providing a core gas turbine engine at least partially defined by a frame and having a drive shaft rotatable about a longitudinal axis of the core gas turbine engine. A low-pressure turbine is coupled to a core turbine engine. A counter-rotating fan assembly is coupled to the low-pressure turbine. The counter-rotating fan assembly includes a first fan assembly and a second fan assembly. A booster compressor is coupled to the second fan assembly. A gearbox is securely coupled to the frame so that the gearbox is circumferentially positioned about the drive shaft. The first fan assembly is rotatably coupled to an input of the gearbox such that the first fan assembly rotates in a first direction. The second fan assembly is rotatably coupled to an output of the gearbox such that the second fan assembly rotates in a second direction opposite the first direction.

Abstract: A method for assembling a gas turbine engine includes coupling a low-pressure turbine to a core turbine engine, coupling a counter-rotating fan assembly including a forward fan assembly and an axially aft fan assembly to the low-pressure turbine such that the forward fan assembly rotates in a first direction and the aft fan assembly rotates in an opposite second direction, and coupling a booster compressor to the low-pressure turbine such that the booster compressor rotates in the first direction.

Abstract: A method for assembling a gas turbine engine includes coupling a low-pressure turbine to a core turbine engine, and coupling a counter-rotating fan assembly including a first fan assembly and a second fan assembly to the low-pressure turbine such that the first fan assembly rotates in a first direction and the second fan assembly rotates in an opposite second direction.