Abstract: A human insulin-like growth factor (IGF) binding protein stock solution and method of making the same include a non-recombinant human IGF binding protein-3 (nr-IGFBP-3) in an aqueous buffered medium. The concentration of the nr-IGFBP-3 in the stock solution ranges from about 16 micrograms per milliliter (?g/ml) to about 40 ?g/ml. A kit includes a set of calibrators for nr-IGFBP-3. The set of calibrators includes the nr-IGFBP-3 in different concentrations.

Abstract: A system for video conference and/or chat analysis. The system has a system server which interfaces between a coaching server and a video conferencing, and/or chat server. The coaching server contains training and coaching data leveraged to facilitate human resource performance improvement activities in resource intensive environments such as human resources, contact centers, or back-office environments. The communication server hosts video conferences and chat sessions respectively. The system server initiates video conferences and/or chat sessions on the communication server based on information received from the coaching server. The system server retrieves a transcript from the communication server after a video conference or a chat transcript during active chat session, parses and processes the video and/or chat transcript and enters the processed transcript into the coaching server.

Abstract: A process and apparatus for handling a rigid sheet is disclosed. The process comprises engaging opposing faces of a sheet at its periphery with engagement means providing a second engagement means, movable relative to the first and engaging the sheet with the second engagement means. The sheet is then moved relative to the second engagement means whilst the sheet is engaged with the first engagement means and is then clamped. The sheet is then moved to a desired orientation or location whilst maintaining the first and second engagement means in fixed relative position. The process is useful in handling glass sheeting and in the production of multiple glazed units and on an insulating glass production line.

Abstract: A human insulin-like growth factor (IGF) binding protein stock solution and method of making the same include a non-recombinant human IGF binding protein-3 (nr-IGFBP-3) in an aqueous buffered medium. The concentration of the nr-IGFBP-3 in the stock solution ranges from about 16 micrograms per milliliter (?g/ml) to about 40 ?g/ml. A kit includes a set of calibrators for nr-IGFBP-3. The set of calibrators includes the nr-IGFBP-3 in different concentrations.

Abstract: The introduction of electronics into a drug delivery device may introduce certain technical challenges, such as durability, electro-mechanical integration, and drug delivery performance. The present disclosure provides solutions for inclusion of an electronics module with an inhaler. For example, heat stakes may be used to secure a printed circuit board (PCB) to an electronics module's housing. Also for example, a slider may be used to transfer vertical movement of an inhaler's yoke to an electronics module's switch. Also for example, certain seals may be used when interfacing the electronics module to other portions of the device's housing to achieve a desired performance.

Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.

Abstract: The present document relates to methods and apparatus for rendering input audio for playback in a playback environment. The input audio includes at least one audio object and associated metadata, and the associated metadata indicates at least a location of the audio object. A method for rendering input audio including divergence metadata for playback in a playback environment comprises creating two additional audio objects associated with the audio object such that respective locations of the two additional audio objects are evenly spaced from the location of the audio object, on opposite sides of the location of the audio object when seen from an intended listener's position in the playback environment, determining respective weight factors for application to the audio object and the two additional audio objects, and rendering the audio object and the two additional audio objects to one or more speaker feeds in accordance with the determined weight factors.

Abstract: The present disclosure relates to methods of treating neurodegeneration and neurodegenerative diseases comprising administering to a subject in need thereof a combination of a SARM1 inhibitor and a neuroprotective agent.

Abstract: A pressure retained gasket seal provides enhanced resistance to hydraulic unloading by including a notch formed in a rear face of the gasket groove, thereby reducing intrusion of process fluid behind the gasket and improving hydraulic retention of the gasket seal. Embodiments increase the process fluid pressure limit of the gasket seal by a factor of two or three compared to gasket seals of the prior art. In embodiments, the gasket groove has a dovetail cross-section, thereby increasing resistance to process fluid pressure by requiring compression of the gasket before it can be dislodged from the groove. Embodiments form the gasket from flexible graphite, which can be initially shaped as an annulus and then forced by an applied load into the gasket groove in conformance with the notch. Embodiments include compressing the graphite to within 50% or even 70% of its maximum density during installation thereof.

Abstract: A method includes receiving, at a user device, a user selection entered into a third-party application to have a payload delivered to a delivery location via an uncrewed aerial vehicle (UAV). The method also includes displaying, by the user device within the third-party application, a first UI portion of a delivery software development kit (SDK). The first UI portion enables user selection of a delivery point at the delivery location. The method additionally includes after user selection of the delivery point, receiving, at the user device, a delivery status update from the delivery SDK indicating that the UAV has commenced delivery of the payload. The method also includes displaying, by the user device within the third-party application, a second UI portion of the delivery SDK. The second UI portion displays UAV tracking information as the UAV delivers the payload to the selected delivery point at the delivery location.

Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.

Abstract: The present disclosure provides compounds useful as inhibitors of SARM1 NADase activity, compositions thereof, and methods of using the same. The present disclosure provides compounds useful for treating a neurodegenerative or neurological disease or disorder, compositions thereof, and methods of using the same.

Abstract: A tiltable floating lip seal accommodates both radial displacements and axial misalignments between a shaft and a housing bore hole. Flexible axial arms at opposing ends of a seal ring assembly form seals with the housing to accommodate tipping and radial displacement of the shaft. The axial arms can be axial lips that slide against radial housing walls. The axial lips can extend from the seal ring assembly or from separate end rings that form lip seals to both the housing and the seal ring assembly. The axial lips can be energized by springs, such as canted coil springs or petalized U-shaped springs. In other embodiments, the distal ends of the flexible axial arms are fixed to the housing, for example compressed between elements of the housing. Buffer fluid can be introduced through ports to press the axial lips against the shaft or lift them slightly to reduce wear.

Abstract: A process and apparatus for handling a rigid sheet is disclosed. The process comprises engaging opposing faces of a sheet at its periphery with engagement means providing a second engagement means, movable relative to the first and engaging the sheet with the second engagement means. The sheet is then moved relative to the second engagement means whilst the sheet is engaged with the first engagement means and is then clamped. The sheet is then moved to a desired orientation or location whilst maintaining the first and second engagement means in fixed relative position. The process is useful in handling glass sheeting and in the production of multiple glazed units and on an insulating glass production line.

Abstract: The present document relates to methods and apparatus for rendering input audio for playback in a playback environment. The input audio includes at least one audio object and associated metadata, and the associated metadata indicates at least a location of the audio object. A method for rendering input audio including divergence metadata for playback in a playback environment comprises creating two additional audio objects associated with the audio object such that respective locations of the two additional audio objects are evenly spaced from the location of the audio object, on opposite sides of the location of the audio object when seen from an intended listener's position in the playback environment, determining respective weight factors for application to the audio object and the two additional audio objects, and rendering the audio object and the two additional audio objects to one or more speaker feeds in accordance with the determined weight factors.

Abstract: The present disclosure provides compounds useful as inhibitors of SARM1 NADase activity, compositions thereof, and methods of using the same. The present disclosure provides compounds useful for treating a neurodegenerative or neurological disease or disorder, compositions thereof, and methods of using the same.

Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.

Abstract: A method for enabling technology delivery using a heatmap with a single pane view is provided. The method may include validating and matching entity requirement data, demand forecast confidence and demand variances data. This ensures that each of the foregoing are combined to form a single format demand management heatmap portal. The method may include validating and matching time-to-market requirement data, at-risk projects data and hardware scarcity data. Once validated and matched, the time-to-market requirement data, the at-risk projects data and the hardware scarcity data may be combined to form a supply side capacity heatmap portal. The method may include validating and matching hardware product shortage data, data center/hosting capacity data and service requirements data. The hardware product shortage data, the data center/hosting capacity data and the service requirements data may then be combined to form a supply side capacity portal to determine availability and delivery risk.

Abstract: A deck extender for a personal watercraft can include a deck member supported in a cantilevered configuration over an edge of the deck of the personal watercraft. The deck extender can include mounting sleeves fixed to an upper deck of a personal watercraft with mounting tabs of the deck member received within the mounting sleeves. The deck member can include mounting mechanisms having a receptacle and a pivoting cleat mounted above the receptacle configured for mounting accessories to the deck member. The deck member can have recessed channel members for mounting accessories.

Abstract: A process and apparatus for handling a rigid sheet is disclosed. The process comprises engaging opposing faces of a sheet at its periphery with engagement means providing a second engagement means, movable relative to the first and engaging the sheet with the second engagement means, The sheet is then moved relative to the second engagement means whilst the sheet is engaged with the first engagement means and is then clamped. The sheet is then moved to a desired orientation or location whilst maintaining the first and second engagement means in fixed relative position. The process is useful in handling glass sheeting and in the production of multiple glazed units and on an insulating glass production line.