Abstract: The present invention encompasses compounds of the formula (I) wherein the variables are defined herein which are suitable for the modulation of ROR? and the treatment of diseases related to the modulation of ROR?. The present invention also encompasses processes of making compounds of formula (I) and pharmaceutical preparations containing them.

Abstract: In one general aspect, an apparatus to monitor movement of an object may include an input device configured to trigger pre-selection of a type of performance of the object, at least one sensor used to measure a motion parameter of the object, a controller configured to receive the motion parameter of the object and compare the measured motion parameter with a motion reference, and an output device configured to display, in real-time, a feedback information based on the comparison.

Abstract: Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (BTK). Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the BTK inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseeases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

Abstract: The present invention encompasses compounds of the formula (I), wherein the variables are defined herein which are suitable for the modulation of RORC and the treatment of diseases related to the modulation of RORC. The present invention also encompasses processes of making compounds of formula (I) and pharmaceutical preparations containing them.

Abstract: The present invention encompasses compounds of the formula (I): wherein the variables are defined herein which are suitable for the modulation of RORC and the treatment of diseases related to the modulation of RORC. The present invention also encompasses processes of making compounds of formula (I) and pharmaceutical preparations containing them.

Abstract: A negotiable instrument such as a check includes a unique microprint identifier that allows for authentication while preventing unauthorized reproduction and alternation. A printing system generates the identifier after receiving a customer order for printing a plurality of negotiable instruments, to allow inclusion of information that is specific to the customer order and/or the printing process. In various embodiments, the identifier is unique to each or each subset of the plurality of negotiable instruments and facilitates authentication of each of the negotiable instruments when needed.

Abstract: A diagnostics unit (10) for detecting a noise, vibration, harshness (NVH) type fault observed by a user of a vehicle (90). The diagnostics unit (10) comprising: a stud type attachment means (20) for rigidly attaching the diagnostics unit (10) to a test component (30) of the vehicle (90), for example a transfer case (30). The diagnostics unit (10) also comprises an accelerometer (28a, 28b) for detecting a force of acceleration in at least one axial direction (‘X’). A power source (27) is provided within the diagnostics unit (10) along with a Bluetooth® data transmitter (25) for transmitting data gathered by the accelerometer (28a, 28b) of the diagnostics unit (10) to a computing device (50), such as a lap-top disposed within the vehicle (90). The data is analysed by the lap-top (50) to identify which component of the transfer case (30) (for example, gear, chain, bearing) is faulty.

Abstract: Disclosed are methods that address providing a subject experiencing, or who has experienced, a headache precursor event and administering dihydroergotamine, or a pharmaceutically acceptable salt or complex thereof, to the subject by oral inhalation, in an amount effective to pre-empt a subsequent headache in the subject. Also disclosed are compositions that are related to those methods.

Abstract: Provided are compositions and methods for use in prophylaxis of puerperal metritis and improving reproductive function of ruminants. The methods and compositions are for subcutaneous administration and are provided as veterinary compositions and as articles of manufacture. The veterinary composition can contain whole cells selected from whole cells of Escherichia coli (E. coli), Trueperella pyogenes (T. pyogenes), Fusobacterium necrophorum (F. necrophorum) and combinations thereof; and/or proteins selected from F. necrophorum leukotoxin (LKT), E. coli type 1 fimbrial adhesin (FimH), T. pyogenes pyolysin (PLO), and all combinations of the whole cells and the proteins.

Abstract: A negotiable instrument such as a check includes a unique microprint identifier that allows for authentication while preventing unauthorized reproduction and alternation. A printing system generates the identifier after receiving a customer order for printing a plurality of negotiable instruments, to allow inclusion of information that is specific to the customer order and/or the printing process. In various embodiments, the identifier is unique to each or each subset of the plurality of negotiable instruments and facilitates authentication of each of the negotiable instruments when needed.

Abstract: The present invention encompasses compounds of the formula (I) wherein the variables are defined herein which are suitable for the modulation of ROR? and the treatment of diseases related to the modulation of ROR?. The present invention also encompasses processes of making compounds of formula (I) and pharmaceutical preparations containing them.

Abstract: A user interface for display and navigation of multiple video programs displays a graphical user interface including a plurality of available video programs. A user is allowed to generate a custom list of video programs by selecting at least one video program from the plurality of video programs. The videos programs from the custom list are simultaneously displayed while displaying the graphical user interface to the user.

Abstract: The present invention encompasses compounds of the formula (I) wherein the variables are defined herein which are suitable for the modulation of ROR? and the treatment of diseases related to the modulation of ROR?. The present invention also encompasses processes of making compounds of formula (I) and pharmaceutical preparations containing them.

Abstract: Provided are compositions and methods for use in prophylaxis of puerperal metritis and improving reproductive function of ruminants. The methods and compositions are for subcutaneous administration and are provided as veterinary compositions and as articles of manufacture. The veterinary composition can contain whole cells selected from whole cells of Escherichia coli (E. coli), Trueperella pyogenes (T. pyogenes), Fusobacterium necrophorum (F. necrophorum) and combinations thereof; and/or proteins selected from F. necrophorum leukotoxin (LKT), E. coli type 1 fimbrial adhesin (FimH), T. pyogenes pyolysin (PLO), and all combinations of the whole cells and the proteins.

Abstract: A reconstitution device having an opening surrounded by a neck, and a cap including a first end, a second end, and an inner bore having a central aperture. A stopper is positioned in the opening of the neck and includes a portion capable of being perforated. A plunger is located at the second end of the cap, is configured to slide along the inner bore of the cap, and includes a shaft extending downwardly in a direction towards the stopper and having a pointed end for piercing the stopper. A locking mechanism is located in the cap and includes an aperture. The locking mechanism is configured such that when the plunger is pushed downwardly the shaft is allowed to pass through the aperture, but when the plunger is pulled upwardly the second aperture changes shape such that the shaft cannot freely pass through the aperture.

Abstract: Apparatus and methods are disclosed for designing and manufacturing a composite structure, such as a composite rotor blade spar or composite rotor blade. A first mold may define a first mold surface and a second mold may include a rigid layer and a heated layer secured to the rigid layer and defining a second mold surface. A plurality of heating elements embedded in the second mold may be activated according to different temperature progressions to cure portions of the uncured composite rotor blade positioned coextensive therewith. In some embodiments, the second mold defines a root portion and first and second branch portions. A shear web may be placed between the branch portions during curing. The blade spar may define a complete airfoil contour or have fairings secured thereto having lines extending therethrough to a tip jet. A tip jet mounting structure and blade root attachment apparatus are also disclosed.

Abstract: An improved leadframe assembly for use in a quad flat no lead (QFN) package is described along with a method of fabricating both the leadframe assembly and the QFN package. The leadframe assembly comprises an etch-stop layer formed on a topside of a substrate and a routing layer (or trace) formed on a topside of the etch-stop layer. The etch-stop layer prevents etching of an underside of the routing trace and the leadframe assembly may also comprise a top plating layer formed on a topside of the routing layer and which prevents etching of the topside of the routing trace.

Abstract: The present invention encompasses compounds of the formula (I): wherein the variables are defined herein which are suitable for the modulation of RORC and the treatment of diseases related to the modulation of RORC. The present invention also encompasses processes of making compounds of formula (I) and pharmaceutical preparations containing them.