Patents by Inventor Robert P. Borris

Robert P. Borris has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Microbial immunoregulant
    Patent number: 5431896
    Abstract: Described is a new immunosuppressant, L-687,819, a C-31 demethylated derivative of L-683,795 (FK-523), produced under fermentation conditions utilizing the new mutant microorganism, Streptomyces hygroscopicus subsp. ascomyceticus (Merck Culture Collection MA 6646) ATCC No. 53855, being a blocked mutant of Streptomyces hygroscopicus subsp. ascomyceticus (MA 6475) ATCC No. 14891. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.
    Type: Grant
    Filed: July 30, 1992
    Date of Patent: July 11, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Louis Kaplan, Robert P. Borris, Kevin M. Byrne, Linda S. Wicker, Deborah L. Zink
  • Antimigraine alkyl indole
    Patent number: 5233050
    Abstract: An alkyl indole of the formula: ##STR1## is a useful antimigraine agent.
    Type: Grant
    Filed: February 7, 1992
    Date of Patent: August 3, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Robert P. Borris, Yiu-Kuen T. Lam, Lawrence Koupal
  • Sterol inhibitors of testosterone 5.alpha.-reductase
    Patent number: 4814324
    Abstract: The compounds of Formula I are produced by the aerobic fermentation of a fungus of the genus GLIOCLADIUM, ATCC No. 20826. ##STR1## The compounds of Formula I are inhibitors of testosterone 5.alpha.-reductase and are useful in the treatment and prevention of acne, seborrhea, female hirsutism and benign prostatic hypertrophy.
    Type: Grant
    Filed: March 6, 1987
    Date of Patent: March 21, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Robert P. Borris, Richard W. Burg, Otto D. Hensens, Leeyuan Huang, Livia Kelemen, Sagrario Mochales