Patents by Inventor Robert P. Hatch
Robert P. Hatch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6872573Abstract: A method of detecting creatinine in body fluids using an indicator which produces a fluorescent response when oxidized in the presence of a copperII/creatinine complex. A preferred indicator is 4-(1-methylhydrazino)-7-nitro benzooxadiazole (MNBDH).Type: GrantFiled: January 2, 2003Date of Patent: March 29, 2005Assignee: Bayer CorporationInventors: James P. Albarella, Robert P. Hatch
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Publication number: 20040132200Abstract: A method of detecting creatinine in body fluids using an indicator which produces a fluorescent response when oxidized in the presence of a copperII/creatinine complex. A preferred indicator is 4-(1-methylhydrazino)-7-nitro benzooxadiazole (MNBDH).Type: ApplicationFiled: January 2, 2003Publication date: July 8, 2004Inventors: James P. Albarella, Robert P. Hatch
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Patent number: 6210978Abstract: Disclosed is a method for the immobilization of an analyte such as deoxypyridinium (DPD) onto a solid support. The method involves binding an antigen-amino acid-deoxypyridinium complex to the support via an anti-antigen binding partner located in a capture zone of the solid support. Preferably, the support is nitrocellulose and the antigen has the fluorescein structure.Type: GrantFiled: March 2, 1998Date of Patent: April 3, 2001Assignee: Bayer CorporationInventors: Robert P. Hatch, Meitak Teresa Yip
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Patent number: 6033918Abstract: Disclosed is an improvement to the technique for immobilizing an analyte onto a solid surface for use in a competitive immunoassay. The improvement involves immobilizing the analyte on the solid surface by reacting the analyte or derivative thereof with polyethylene glycol which has been functionalized with a group which is reactive with the analyte contacting the resulting conjugate with the solid surface to thereby immobilize the analyte.Type: GrantFiled: November 10, 1997Date of Patent: March 7, 2000Assignee: Bayer CorporationInventors: Robert P. Hatch, Meitak Teresa Yip
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Patent number: 5723619Abstract: Disclosed is a method for the chemical synthesis of deoxypyridinoline (DPD). The synthesis involves the preparation of a protected 3-hydroxypyridinium starting with a N.alpha.-protected lysine and a 5,6-epoxy-2-N-protected-O-protected-(2S)-2-aminohexanoate with subsequent deprotection to provide the desired DPD.Type: GrantFiled: January 13, 1997Date of Patent: March 3, 1998Assignee: Bayer CorporationInventor: Robert P. Hatch
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Patent number: 5520883Abstract: Test devices are disclosed which are useful for determining glucose or occult blood comprising a carrier matrix, glucose oxidase, an indicator system and a glucose derivative that upon addition of water hydrolizes to produce glucose.Type: GrantFiled: September 5, 1989Date of Patent: May 28, 1996Assignee: Miles Inc.Inventors: Steven C. Charlton, Robert P. Hatch, Paul R. Hemmes
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Patent number: 5468641Abstract: The present invention involves the use of certain indole sulfonates in a test control method for the Ehrlich reagent used in diagnostic tests for urobilinogen. The indole sulfonates exhibit unique solubility characteristics which facilitate their application to dry carrier matrixes with subsequent rehydration during their use in the test control method.Type: GrantFiled: May 3, 1994Date of Patent: November 21, 1995Assignee: Bayer CorporationInventors: Robert P. Hatch, Marilyn J. Radtke
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Patent number: 5300637Abstract: 2-Benzothiazolyl tetrazolium salt compounds have been found to be characterized by a reflectance spectrum exhibiting an extended plateau above about 600-650 nm. Such compounds are useful as chromogenic indicators for reducing substances such as NADH. The reflectance plateau confers improved accuracy to analytical assays, particularly for the determination of analytes of medical diagnostic significance, in which a colorimetric response on a reagent carrier matrix is measured by reflectance.Type: GrantFiled: June 18, 1993Date of Patent: April 5, 1994Assignee: Miles Inc.Inventors: Robert P. Hatch, Nan-Horng Lin, Scott Ruetten
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Patent number: 5250695Abstract: Disclosed are sulfonate and phosphonate salts of tetrazolium compounds whose enhanced solubility in various solvents renders them particularly suitable for use as redox indicators in dry reagent, diagnostic test systems.Type: GrantFiled: June 15, 1992Date of Patent: October 5, 1993Assignee: Miles Inc.Inventors: Joel M. Blatt, Robert P. Hatch
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Patent number: 5187265Abstract: The present invention relates to a chromogenic benzoisothiazolone polymer derivative for measuring the presence or appearance of thiols in an aqueous system.Type: GrantFiled: February 28, 1992Date of Patent: February 16, 1993Assignee: Miles Inc.Inventors: James P. Albarella, David L. Garling, Robert P. Hatch
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Patent number: 5187105Abstract: A process for measuring the presence or appearance of thiols in aqueous system, the process involving contacting the aqueous system with a chromogenic thiol indicating benzoisothiazolone derivative and then observing chromophoric changes due to thiol mediated reduction of the benzoisothiazolone derivative wherein the changes are proportional to the amount or rate of appearance of the thiols in the aqueous system.Type: GrantFiled: February 25, 1991Date of Patent: February 16, 1993Assignee: Miles Inc.Inventors: James P. Albarella, David L. Garling, Robert P. Hatch
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Patent number: 5130433Abstract: Newly synthesized chromogenic thiol-indicating benzoisothiazolone derivatives having the structure: ##STR1## where R.sup.1, R.sup.2 and R.sup.3 are as defined in the specification, are useful in the detection of thiols, particularly in an aqueous system. This process comprises contacting the aqueous system with a chromogenic thiol-indicating benzoisothiazolone derivative as described herein. Chromophoric changes due to thiol-mediated reduction of the benzothiazolone derivative then occur. Such changes can be in a solution or on an indicator surface in contact or having been in contact with the aqueous system. The chromophoric changes, due to a bathochromic shift in characteristic light absorption upon reduction of the benzoisothiazolone derivative, are proportional to the amount or rate of appearance of thiols in the aqueous system.Type: GrantFiled: July 2, 1990Date of Patent: July 14, 1992Assignee: Miles Inc.Inventors: James P. Albarella, David L. Garling, Robert P. Hatch
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Patent number: 5128457Abstract: Newly synthesized chromogenic thiol-indicating benzoisthiazolone derivatives having the structure: ##STR1## where R.sup.1, R.sup.2 and R.sup.3 are as defined in the specification, are useful in the detection of thiols, particularly in an aqueous system. This process comprises contacting the aqueous system with a chromogenic thiol-indicating benzoisothiazolone derivative as described herein. Chromophoric changes due to thiol-mediated reduction of the benzothiazolone derivative then occur. Such changes can be in a solution or on an indicator surface in contact or having been in contact with the aqueous system. The chromophoric changes, due to a bathochromic shift in characteristics light absorption upon reduction of the benzoisothiazolone derivative, are proportional to the amount or rate of appearance of thiols in the aqueous system.Type: GrantFiled: December 5, 1991Date of Patent: July 7, 1992Assignee: Miles Inc.Inventors: James P. Albarella, David L. Garling, Robert P. Hatch
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Patent number: 5126275Abstract: General classes of 2-thiazolyl tetrazolium salt compounds have been found to be characterized by a reflectance spectrum exhibiting an extended plateau above about 600-650 nm. Such compounds are useful as chromogenic indicators for reducing substances such as NADH. The reflectance plateau confers improved accuracy to analytical assays, particularly for the determination of analytes of medical diagnostic significance, in which a colorimetric response on a reagent carrier matrix is measured by reflectance.Type: GrantFiled: September 19, 1990Date of Patent: June 30, 1992Assignee: Miles Inc.Inventors: Robert P. Hatch, Jurgen Kocher, Nan-Horng Lin, Scott Ruetten, Klaus Wehling
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Patent number: 5081044Abstract: Optical indicator chalcogen (selenide or sulfide) compounds responsive to oxidants, e.g., hydrogen peroxide, and a method for using such indicators. Upon oxidation the resulting intermediate undergoes spontaneous elimination of the chalcogen residue to yield a signal compound which provides an optical signal such as fluorescence. Preferred fluorogenic indicator compounds are 3-chalcogen-3,4-dihydrocoumarin derivatives and 3-chalcogen-3,4-dihydro-2-quinolone derivatives. Such indicator compounds provide highly fluorescent products upon oxidation by hydrogen peroxide and are useful in analytical systems which generate hydrogen peroxide in response to the analyte under determination.Type: GrantFiled: September 28, 1990Date of Patent: January 14, 1992Assignee: Miles Inc.Inventors: Robert T. Buckler, Robert P. Hatch
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Patent number: 4996332Abstract: Optical indicator chalcogen (selenide or sulfide) compounds responsive to oxidants, e.g., hydrogen peroxide, and methods for preparing and using such indicators. Upon oxidation the resulting intermediate undergoes spontaneous elimination of the chalcogen residue to yield a signal compound which provides an optical signal such as fluorescence. Preferred fluorogenic indicator compounds are 3-chalcogen-3,4-dihydrocoumarin derivatives and 3-chalcogen-3,4-dihydro-2-quinolone derivatives. Such indicator compounds provide highly fluorescent products upon oxidation by hydrogen peroxide and are useful in analytical systems which generate hydrogen peroxide in response to the analyte under determination.Type: GrantFiled: June 13, 1988Date of Patent: February 26, 1991Assignee: Miles Inc.Inventors: Robert T. Buckler, Robert P. Hatch
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Patent number: 4895798Abstract: Test devices are disclosed which are useful for determining glucose or occult blood comprising a carrier matrix, glucose oxidase, an indicator system and a glucose derivative that upon addition of water hydrolizes to produce glucose.Type: GrantFiled: November 13, 1987Date of Patent: January 23, 1990Assignee: Miles, Inc.Inventors: Steven C. Charlton, Robert P. Hatch, Paul R. Hemmes
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Patent number: 4806631Abstract: Immobilization of nucleic acids, e.g., DNA and RNA, by contact with a solid support comprising nylon whose amide groups have been partially solvolyzed. Solvolysis of the nylon support can be accomplished by treatment with an alkylating agent such as a trialkyloxonium salt under anhydrous conditions followed by addition of water. The immobilized nucleic acid is particularly useful as an immobilized probe in hybridization assays to detect specific polynucleotide sequences in a test sample.Type: GrantFiled: September 30, 1985Date of Patent: February 21, 1989Assignee: Miles Inc.Inventors: Robert J. Carrico, Robert P. Hatch, William L. Patterson
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Determination of hydrogen peroxide using fluorogenic dihydroquinolone and dihydrocoumarin indicators
Patent number: 4794079Abstract: Fluorogenic indicator compounds responsive to the presence of hydrogen peroxide and methods and test compositions for determining hydrogen peroxide in a test sample. Preferred indicator compounds are 3,4-dihydrocoumarin derivatives and 3,4-dihydro-2-quinolone derivatives, especially those having a dialkylamino group at the 7-position. Such particularly preferred compounds are of the formula: ##STR1## wherein R.sup.1 is hydrogen, cyano, or --COOR.sup.6, --CONHR.sup.6 or --CON(R.sup.6).sub.2 where R.sup.6 is hydrogen, alkyl, alkenyl, or aryl; R.sup.3 and R.sup.4 are lower alkyl; and Y is .dbd.0 or .dbd.N--R.sup.5 where R.sup.5 is hydrogen or lower alkyl. The indicator compounds yield highly fluorescent products upon oxidation by hydrogen peroxide in the presence of a peroxidatively active substance and are useful in analytical systems which generate hydrogen peroxide in response to an analyte under determination in a test sample.Type: GrantFiled: September 30, 1985Date of Patent: December 27, 1988Assignee: Miles Inc.Inventors: Robert T. Buckler, Robert P. Hatch -
Patent number: 4778893Abstract: Optical indicator chalcogen (selenide or sulfide) compounds responsive to oxidants, e.g., hydrogen peroxide, and methods for preparing and using such indicators. Upon oxidation the resulting intermediate undergoes spontaneous elimination of the chalcogen residue to yield a signal compound which provides an optical signal such as fluorescence. Preferred fluorogenic indicator compounds are 3-chalcogen-3,4-dihydrocoumarin derivatives and 3-chalcogen-3,4-dihydro-2-quinolone derivatives. Such indicator compounds provide highly fluorescent products upon oxidation by hydrogen peroxide and are useful in analytical systems which generate hydrogen peroxide in response to the analyte under determination.Type: GrantFiled: January 5, 1987Date of Patent: October 18, 1988Assignee: Miles Inc.Inventors: Robert T. Buckler, Robert P. Hatch