Abstract: A cut guide includes a first face and an opposed second face. The cut guide further includes a first aperture and a second aperture extending through the cut guide from the first face to the second face. The first and second apertures are configured to guide a surgical tool in cutting a bone. The cut guide further includes a first hole extending through the cut guide from the first face to the second face. The cut guide further includes a second hole extending through the cut guide. A central axis of the second hole is oriented at an acute angle to the second face. The first and second holes are configured to receive a wire to position the guide against the bone.

Abstract: A cut guide includes a first face and an opposed second face. The cut guide further includes a first aperture and a second aperture extending through the cut guide from the first face to the second face. The first and second apertures are configured to guide a surgical tool in cutting a bone. The cut guide further includes a first hole extending through the cut guide from the first face to the second face. The cut guide further includes a second hole extending through the cut guide. A central axis of the second hole is oriented at an acute angle to the second face. The first and second holes are configured to receive a wire to position the guide against the bone.

Abstract: A power control system is provided for AC mains, including an input bridge rectifier connected to the AC power mains, and a buck regulator circuit connected to the DC output of the input bridge rectifier, the output of the buck regulator circuit providing a DC power output bus. A current sensor is connected to the output of the buck regulator circuit, and one or more capacitors is connected across the DC power output bus for receiving current from the buck regulator circuit. The buck regulator circuit is controlled to limit peak output current thereof.

Abstract: Networked automation systems having electric actuation from a high voltage source. The electric actuator includes a switch mode power supply coupled to the high voltage source as a principal power source. The networked automation systems include a controller device having an output network port wired to an input network port of the motor drive. The controller device is also coupled to an auxiliary source of power. Thus, a regulation circuit of the switch mode power supply can be coupled to the auxiliary source of power, thereby providing power for the regulation circuit at start up.

Abstract: Apparatus and methods for jet impingement cooling are provided. In one arrangement, a fluid channelling structure engages against a target surface to define a flow volume. Fluid is jetted onto the target surface from inlets and is removed via outlets. Flow directing features form a plurality of channels with no straight paths between inlets and outlets. A time averaged flow direction of fluid in contact with each flow directing feature is more nearly perpendicular to a direction of jetting of the fluid from a nearest inlet than parallel to the direction of jetting One or more pairs of the inlets and outlets are such that a majority of fluid jetted onto the target surface from the inlet of the pair will be removed from the flow volume through the outlet of the same pair.

Abstract: An electric motor drive system is provided wherein safety is achieved by commanding the process system of the relevant axis or set of axes to execute motion that follows a defined path, namely trajectory of position, velocity and acceleration against time, re-constructing an identical trajectory in the safety system and in, the safety system, supervising deviations between the safely reconstructed target position and the safe measurement of position.

Abstract: The present disclosure relates to a method for the manufacture of recombinant antibody molecules comprising culturing a host cell sample transformed with an expression vector encoding a recombinant antibody molecule; adding an extraction buffer to the sample; and subjecting the sample to a heat treatment step; wherein the pH of the sample is detected after addition of the extraction buffer, and optionally adjusted, to ensure that the pH of the sample is 6 to 9 prior to the heat treatment step.

Abstract: The present invention relates to a process for the purification of an antibody fragment from a periplasmic cell extract comprising a first cation exchange chromatography step and a second anion exchange chromatography step.

Abstract: The present disclosure relates to a method for the manufacture of recombinant antibody molecules comprising culturing a host cell sample transformed with an expression vector encoding a recombinant antibody molecule; adding an extraction buffer to the sample; and subjecting the sample to a heat treatment step; wherein the pH of the sample is detected after addition of the extraction buffer, and optionally adjusted, to ensure that the pH of the sample is 6 to 9 prior to the heat treatment step.

Abstract: A torque-limiting safety circuit servo drive for AC permanent magnet motors including a three-phase inverter bridge, a first current sensor in series with a first motor phase, a second current sensor in series with a second motor phase, a third current sensor in series with the DC bus, and a drive control circuit that controls the six pulse-width modulated gate drive signals for the three-phase inverter bridge. The drive circuit has first and second safety channel STO inputs whereby either channel can shut down the three-phase inverter bridge, emits a signal set to represent the switching state of the three-phase inverter bridge, and modifies the switching pattern of the PWM to ensure the dwell times of PWM is sufficiently long to allow a valid measurement of phase current using the bus current sensor. First and second safety processors controls the first and second safety channel STO inputs, respectively.

Abstract: The present invention relates to a process for the purification of an antibody fragment from a periplasmic cell extract comprising a first cation exchange chromatography step and a second anion exchange chromatography step.

Abstract: An electric motor drive system is provided wherein safety is achieved by commanding the process system of the relevant axis or set of axes to execute motion that follows a defined path, namely trajectory of position, velocity and acceleration against time, re-constructing an identical trajectory in the safety system and in, the safety system, supervising deviations between the safely reconstructed target position and the safe measurement of position.

Abstract: Apparatus and methods for jet impingement cooling are provided. In one arrangement, a fluid channeling structure engages against a target surface to define a flow volume. Fluid is jetted onto the target surface from inlets and is removed via outlets. Flow directing features form a plurality of channels with no straight paths between inlets and outlets. A time averaged flow direction of fluid in contact with each flow directing feature is more nearly perpendicular to a direction of jetting of the fluid from a nearest inlet than parallel to the direction of jetting One or more pairs of the inlets and outlets are such that a majority of fluid jetted onto the target surface from the inlet of the pair will be removed from the flow volume through the outlet of the same pair.

Abstract: A power control system is provided for AC mains, including an input bridge rectifier connected to the AC power mains, and a buck regulator circuit connected to the DC output of the input bridge rectifier, the output of the buck regulator circuit providing a DC power output bus. A current sensor is connected to the output of the buck regulator circuit, and one or more capacitors is connected across the DC power output bus for receiving current from the buck regulator circuit. The buck regulator circuit is controlled to limit peak output current thereof.

Abstract: A torque-limiting safety circuit servo drive for AC permanent magnet motors including a three-phase inverter bridge, a first current sensor in series with a first motor phase, a second current sensor in series with a second motor phase, a third current sensor in series with the DC bus, and a drive control circuit that controls the six pulse-width modulated gate drive signals for the three-phase inverter bridge. The drive circuit has first and second safety channel STO inputs whereby either channel can shut down the three-phase inverter bridge, emits a signal set to represent the switching state of the three-phase inverter bridge, and modifies the switching pattern of the PWM to ensure the dwell times of PWM is sufficiently long to allow a valid measurement of phase current using the bus current sensor. First and second safety processors controls the first and second safety channel STO inputs, respectively.

Abstract: An over-voltage comparator and shutdown circuit for a power converter, comprising at least a first voltage divider connected between ground and a monitored voltage, the voltage divider including a first resistor and a second resistor, a switch mode regulator connected to a primary switch of the power converter, and a first threshold comparator, wherein a monitored input of the first threshold comparator is connected between the first resistor and the second resistor, an anode of the first threshold comparator is connected to ground, and a cathode of the first threshold comparator is connected to the switch mode regulator, and wherein the monitored voltage is voltage at an end of a primary winding of the power converter. An auxiliary output circuit of the power converter may be provided having a first output providing the monitored voltage and a second output providing power to the switch mode regulator.

Abstract: A device for communicating and providing power over a cable having at least two conductors comprises an inductor having two secondary windings and one primary winding, and a transceiver coupled to the primary winding of the inductor, the two secondary windings of the inductors being coupled to two of the at least two conductors of the cable. Further, a voltage signal provided by the secondary windings of the inductors to the conductors varies symmetrically from an average potential. The inductor of the device can also comprise two primary windings connected in series and two secondary windings connected in series, the secondary windings also connected to two of the at least two conductors in the cable, wherein the voltage signal provided to the two conductors from the secondary windings varies symmetrically from an average potential.

Abstract: The present invention provides therapeutic formulations, including therapeutic nanoemulsions, and related methods for the in vivo delivery of hydrophobic compounds, including an important class of hydrophobic anesthetics. Formulations and methods of the invention include semifluorinated block copolymers and perhalogenated fluorous compounds, such as perfluorooctyl bromide or perfluorodecalin, capable of forming a stable nanoemulsion without the need of conventional lipid components that support bacterial and/or fungal growth (e.g., soybean oil and similar lipids). In certain embodiments, emulsion-based formulations are provided that are capable of formulating, delivering and releasing amounts of hydrophobic drugs effective for a range of clinical applications, including inducing and maintaining anesthesia in patients.

Abstract: An over-voltage comparator and shutdown circuit for a power converter, comprising at least a first voltage divider connected between ground and a monitored voltage, the voltage divider including a first resistor and a second resistor, a switch mode regulator connected to a primary switch of the power converter, and a first threshold comparator, wherein a monitored input of the first threshold comparator is connected between the first resistor and the second resistor, an anode of the first threshold comparator is connected to ground, and a cathode of the first threshold comparator is connected to the switch mode regulator, and wherein the monitored voltage is voltage at an end of a primary winding of the power converter. An auxiliary output circuit of the power converter may be provided having a first output providing the monitored voltage and a second output providing power to the switch mode regulator.

Abstract: The present disclosure relates to a method for the manufacture of recombinant antibody molecules comprising culturing a host cell sample transformed with an expression vector encoding a recombinant antibody molecule; adding an extraction buffer to the sample; and subjecting the sample to a heat treatment step; wherein the pH of the sample is detected after addition of the extraction buffer, and optionally adjusted, to ensure that the pH of the sample is 6 to 9 prior to the heat treatment step.