Abstract: Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic or general biophysical release process.

Abstract: Provided are novel prodrug salts of selective aquaporin inhibitors, their use as pharmaceuticals, and pharmaceutical compositions comprising them, and novel processes for their synthesis and novel intermediates for use in their synthesis. Also provided is use of a compound for the prophylaxis, treatment, and control of aquaporin-mediated conditions. Aquaporin inhibitors, e.g., inhibitors of AQP4 and/or AQP2, may be of utility in the treatment or control of diseases of water imbalance, for example edema (particularly edema of the brain and spinal cord), hyponatremia, and excess fluid retention, as well as diseases such as epilepsy, retinal ischemia and other diseases of the eye, myocardial ischemia, myocardial ischemia/reperfusion injury, myocardial infarction, myocardial hypoxia, congestive heart failure, sepsis, and neuromyelitis optica, as well as migraines.

Abstract: Methods and systems for transmitting uplink control information and feedback are disclosed for carrier aggregation systems. A user equipment device may be configured to transmit uplink control information and other feedback for several downlink component carriers using one or more uplink component carriers. The user equipment device may be configured to transmit such data using a physical uplink control channel rather than a physical uplink shared channel. The user equipment device may be configured to determine the uplink control information and feedback data that is to be transmitted, the physical uplink control channel resources to be used to transmit the uplink control information and feedback data, and how the uplink control information and feedback data may be transmitted over the physical uplink control channel.

Abstract: Disclosed are pharmaceutically acceptable topical formulations having enhanced potency in the alleviation of pain. Such formulations can be useful in the treatment of conditions such as back, skeletal, and joint pain, where the pharmaceutically acceptable topical formulations are applied topically to the site of pain.

Abstract: Disclosed are methods of treatment of neuropathic pain such as fibromyalgia induced neuropathic pain by use of patches, simultaneously, on the top and the bottom of a foot of an individual where the patches contain a formulation topically applied to the skin of the foot.

Abstract: A system for managing power on distributed devices may include a first device having a master logic and a second device having a slave logic. The master logic may enable the first device to communicate with multiple devices having the slave logic on one or more channels. The slave logic may enable the second device having the slave logic to communicate with the first device and to communicate with a third device having the slave logic. The slave logic may enable the multiple devices having the slave logic to manage operations of the distributed devices.

Abstract: A fuel injector for a gas turbine engine of an aircraft having a fuel nozzle including a fuel swirler and/or an outer air swirler. The fuel swirler may include a manifold for receiving fuel from a fuel conduit, and a plurality of fuel passages to direct fuel from the manifold to discharge orifices that direct fuel with swirling flow. The fuel swirler may be configured to provide uniform spray while minimizing recirculation zones; reduce residence time as fuel enters the manifold; minimize flow disruptions, boundary layer growth, and/or pressure drop as fuel flows through the fuel passages; reduces coking internally of the nozzle; reduces thermal stresses; and is simple and low-cost to manufacture. The outer air swirler may include first and second outer air swirler portions with respective vanes and air passages that provide swirling air flow.

Abstract: A system for serial communication may include a first device and a plurality of devices on a series connection. The first device may have a master circuit and the plurality devices may have a slave circuit. The master circuit may enable the first device to communicate with the plurality devices having the slave circuit on the series connection. The master circuit may enable the first device to send a command frame on the series connection. The command frame may include an execution mode command and a plurality of commands. The second devices may execute the commands within the command frame at or after the end of the command frame based on the execution mode command indicating a synchronous mode of command execution; and may execute the commands within the command frame at the ends of individual ones of the commands based on the execution mode command indicating a non-synchronous mode of command execution.

Abstract: A fuel injector for a gas turbine engine of an aircraft having a fuel nozzle including a fuel swirler and/or an outer air swirler. The fuel swirler may include a manifold for receiving fuel from a fuel conduit, and a plurality of fuel passages to direct fuel from the manifold to discharge orifices that direct fuel with swirling flow. The fuel swirler may be configured to provide uniform spray while minimizing recirculation zones; reduce residence time as fuel enters the manifold; minimize flow disruptions, boundary layer growth, and/or pressure drop as fuel flows through the fuel passages; reduces coking internally of the nozzle; reduces thermal stresses; and is simple and low-cost to manufacture. The outer air swirler may include first and second outer air swirler portions with respective vanes and air passages that provide swirling air flow.

Abstract: A system for managing power on distributed devices may include a first device having a master logic and a second device having a slave logic. The master logic may enable the first device to communicate with multiple devices having the slave logic on one or more channels. The slave logic may enable the second device having the slave logic to communicate with the first device and to communicate with a third device having the slave logic. The slave logic may enable the multiple devices having the slave logic to manage operations of the distributed devices.

Abstract: A system for serial communication may include a first device and a plurality of devices on a series connection. The first device may have a master circuit and the plurality devices may have a slave circuit. The master circuit may enable the first device to communicate with the plurality devices having the slave circuit on the series connection. The master circuit may enable the first device to send a command frame on the series connection. The command frame may include an execution mode command and a plurality of commands. The second devices may execute the commands within the command frame at or after the end of the command frame based on the execution mode command indicating a synchronous mode of command execution; and may execute the commands within the command frame at the ends of individual ones of the commands based on the execution mode command indicating a non-synchronous mode of command execution.

Abstract: A system for serial communication may include a first device and a plurality of devices on a series connection. The first device may have a master circuit and the plurality devices may have a slave circuit. The master circuit may enable the first device to communicate with the plurality devices having the slave circuit on the series connection. The master circuit may enable the first device to send a command frame on the series connection. The command frame may include an execution mode command and a plurality of commands. The second devices may execute the commands within the command frame at or after the end of the command frame based on the execution mode command indicating a synchronous mode of command execution; and may execute the commands within the command frame at the ends of individual ones of the commands based on the execution mode command indicating a non-synchronous mode of command execution.

Abstract: A system that provides intelligent constant on-time control may include a first switch coupled to a power input; a second switch coupled to the first switch; a switching node between the first switch and the second switch, the switching node configured to be connected to an inductor and a power output; feedback paths coupled to (1) a synthesized node and (2) the power output, the feedback paths enabling feedback of signals from (1) the synthesized node, and (2) the power output; and a controller coupled to the feedback paths. The controller may be configured to control a voltage at the power output based on a combination of the signals carried by the feedback paths.

Abstract: A fuel injector for a gas turbine engine of an aircraft having a fuel nozzle including a fuel swirler and/or an outer air swirler. The fuel swirler may include a manifold for receiving fuel from a fuel conduit, and a plurality of fuel passages to direct fuel from the manifold to discharge orifices that direct fuel with swirling flow. The fuel swirler may be configured to provide uniform spray while minimizing recirculation zones; reduce residence time as fuel enters the manifold; minimize flow disruptions, boundary layer growth, and/or pressure drop as fuel flows through the fuel passages; reduces coking internally of the nozzle; reduces thermal stresses; and is simple and low-cost to manufacture. The outer air swirler may include first and second outer air swirler portions with respective vanes and air passages that provide swirling air flow.

Abstract: A system that provides intelligent constant on-time control may include a first switch coupled to a power input; a second switch coupled to the first switch; a switching node between the first switch and the second switch, the switching node configured to be connected to an inductor and a power output; feedback paths coupled to (1) a synthesized node and (2) the power output, the feedback paths enabling feedback of signals from (1) the synthesized node, and (2) the power output; and a controller coupled to the feedback paths. The controller may be configured to control a voltage at the power output based on a combination of the signals carried by the feedback paths.

Abstract: A fuel injector for a gas turbine engine of an aircraft having a fuel nozzle including a fuel swirler and/or an outer air swirler. The fuel swirler may include a manifold for receiving fuel from a fuel conduit, and a plurality of fuel passages to direct fuel from the manifold to discharge orifices that direct fuel with swirling flow. The fuel swirler may be configured to provide uniform spray while minimizing recirculation zones; reduce residence time as fuel enters the manifold; minimize flow disruptions, boundary layer growth, and/or pressure drop as fuel flows through the fuel passages; reduces coking internally of the nozzle; reduces thermal stresses; and is simple and low-cost to manufacture. The outer air swirler may include first and second outer air swirler portions with respective vanes and air passages that provide swirling air flow.

Abstract: A system that provides intelligent constant on-time control may include a first switch coupled to a power input; a second switch coupled to the first switch; a switching node between the first switch and the second switch, the switching node configured to be connected to an inductor and a power output; feedback paths coupled to (1) a synthesized node and (2) the power output, the feedback paths enabling feedback of signals from (1) the synthesized node, and (2) the power output; and a controller coupled to the feedback paths. The controller may be configured to control a voltage at the power output based on a combination of the signals carried by the feedback paths.

Abstract: A fuel injector for a gas turbine engine of an aircraft having a fuel nozzle including a fuel swirler and/or an outer air swirler. The fuel swirler may include a manifold for receiving fuel from a fuel conduit, and a plurality of fuel passages to direct fuel from the manifold to discharge orifices that direct fuel with swirling flow. The fuel swirler may be configured to provide uniform spray while minimizing recirculation zones; reduce residence time as fuel enters the manifold; minimize flow disruptions, boundary layer growth, and/or pressure drop as fuel flows through the fuel passages; reduces coking internally of the nozzle; reduces thermal stresses; and is simple and low-cost to manufacture.

Abstract: A fuel injector for a gas turbine engine of an aircraft having a fuel nozzle including a fuel swirler and/or an outer air swirler. The fuel swirler may include a manifold for receiving fuel from a fuel conduit, and a plurality of fuel passages to direct fuel from the manifold to discharge orifices that direct fuel with swirling flow. The fuel swirler may be configured to provide uniform spray while minimizing recirculation zones; reduce residence time as fuel enters the manifold; minimize flow disruptions, boundary layer growth, and/or pressure drop as fuel flows through the fuel passages; reduces coking internally of the nozzle; reduces thermal stresses; and is simple and low-cost to manufacture.

Abstract: A system for managing power on distributed devices may include a first device having a master logic and a second device having a slave logic. The master logic may enable the first device to communicate with multiple devices having the slave logic on one or more channels. The slave logic may enable the second device having the slave logic to communicate with the first device and to communicate with a third device having the slave logic. The slave logic may enable the multiple devices having the slave logic to manage operations of the distributed devices.