Abstract: The present application relates to compounds of Formula (I), as defined herein, and pharmaceutically acceptable salts thereof. The present application also describes pharmaceutical composition comprising a compound of Formula (I), and pharmaceutically acceptable salts thereof, and methods of using the compounds and compositions for treating diseases, such as cancer, autoimmune disorders, and inflammatory disorders.

Abstract: Disclosed are methods of treatment of neuropathic pain such as fibromyalgia induced neuropathic pain by use of patches, simultaneously, on the top and the bottom of a foot of an individual where the patches contain a formulation topically applied to the skin of the foot.

Abstract: Disclosed are pharmaceutically acceptable topical formulations having enhanced potency in the alleviation of pain. Such formulations can be useful in the treatment of conditions such as back, skeletal, and joint pain, where the pharmaceutically acceptable topical formulations are applied topically to the site of pain.

Abstract: A fuel injector for a gas turbine engine of an aircraft having a fuel nozzle including a fuel swirler and/or an outer air swirler. The fuel swirler may include a manifold for receiving fuel from a fuel conduit, and a plurality of fuel passages to direct fuel from the manifold to discharge orifices that direct fuel with swirling flow. The fuel swirler may be configured to provide uniform spray while minimizing recirculation zones; reduce residence time as fuel enters the manifold; minimize flow disruptions, boundary layer growth, and/or pressure drop as fuel flows through the fuel passages; reduces coking internally of the nozzle; reduces thermal stresses; and is simple and low-cost to manufacture. The outer air swirler may include first and second outer air swirler portions with respective vanes and air passages that provide swirling air flow.

Abstract: A fuel injector for a gas turbine engine of an aircraft having a fuel nozzle including a fuel swirler and/or an outer air swirler. The fuel swirler may include a manifold for receiving fuel from a fuel conduit, and a plurality of fuel passages to direct fuel from the manifold to discharge orifices that direct fuel with swirling flow. The fuel swirler may be configured to provide uniform spray while minimizing recirculation zones; reduce residence time as fuel enters the manifold; minimize flow disruptions, boundary layer growth, and/or pressure drop as fuel flows through the fuel passages; reduces coking internally of the nozzle; reduces thermal stresses; and is simple and low-cost to manufacture. The outer air swirler may include first and second outer air swirler portions with respective vanes and air passages that provide swirling air flow.

Abstract: A fuel injector for a gas turbine engine of an aircraft having a fuel nozzle including a fuel swirler and/or an outer air swirler. The fuel swirler may include a manifold for receiving fuel from a fuel conduit, and a plurality of fuel passages to direct fuel from the manifold to discharge orifices that direct fuel with swirling flow. The fuel swirler may be configured to provide uniform spray while minimizing recirculation zones; reduce residence time as fuel enters the manifold; minimize flow disruptions, boundary layer growth, and/or pressure drop as fuel flows through the fuel passages; reduces coking internally of the nozzle; reduces thermal stresses; and is simple and low-cost to manufacture. The outer air swirler may include first and second outer air swirler portions with respective vanes and air passages that provide swirling air flow.

Abstract: A fuel injector for a gas turbine engine of an aircraft having a fuel nozzle including a fuel swirler and/or an outer air swirler. The fuel swirler may include a manifold for receiving fuel from a fuel conduit, and a plurality of fuel passages to direct fuel from the manifold to discharge orifices that direct fuel with swirling flow. The fuel swirler may be configured to provide uniform spray while minimizing recirculation zones; reduce residence time as fuel enters the manifold; minimize flow disruptions, boundary layer growth, and/or pressure drop as fuel flows through the fuel passages; reduces coking internally of the nozzle; reduces thermal stresses; and is simple and low-cost to manufacture. The outer air swirler may include first and second outer air swirler portions with respective vanes and air passages that provide swirling air flow.

Abstract: A fuel injector for a gas turbine engine of an aircraft having a fuel nozzle including a fuel swirler and/or an outer air swirler. The fuel swirler may include a manifold for receiving fuel from a fuel conduit, and a plurality of fuel passages to direct fuel from the manifold to discharge orifices that direct fuel with swirling flow. The fuel swirler may be configured to provide uniform spray while minimizing recirculation zones; reduce residence time as fuel enters the manifold; minimize flow disruptions, boundary layer growth, and/or pressure drop as fuel flows through the fuel passages; reduces coking internally of the nozzle; reduces thermal stresses; and is simple and low-cost to manufacture.

Abstract: A fuel injector for a gas turbine engine of an aircraft having a fuel nozzle including a fuel swirler and/or an outer air swirler. The fuel swirler may include a manifold for receiving fuel from a fuel conduit, and a plurality of fuel passages to direct fuel from the manifold to discharge orifices that direct fuel with swirling flow. The fuel swirler may be configured to provide uniform spray while minimizing recirculation zones; reduce residence time as fuel enters the manifold; minimize flow disruptions, boundary layer growth, and/or pressure drop as fuel flows through the fuel passages; reduces coking internally of the nozzle; reduces thermal stresses; and is simple and low-cost to manufacture.

Abstract: A fuel injector for a gas turbine engine of an aircraft having a fuel nozzle including a fuel swirler and/or an outer air swirler. The fuel swirler may include a manifold for receiving fuel from a fuel conduit, and a plurality of fuel passages to direct fuel from the manifold to discharge orifices that direct fuel with swirling flow. The fuel swirler may be configured to provide uniform spray while minimizing recirculation zones; reduce residence time as fuel enters the manifold; minimize flow disruptions, boundary layer growth, and/or pressure drop as fuel flows through the fuel passages; reduces coking internally of the nozzle; reduces thermal stresses; and is simple and low-cost to manufacture.

Abstract: A nozzle assembly (10) comprising a first inlet tube (14), a second inlet tube (15), and a nozzle (16). The nozzle (16) is formed from a stack of plates (20-38) which are joined together in face-to-face contact. The plates (20-38) collectively have openings which define a nozzle outlet, a first inlet, a second inlet, a first circuit from the first inlet to the nozzle outlet, a second circuit from the second inlet to the nozzle outlet, and a fluid-outlet chamber through which both the first circuit and the second circuit pass. The nozzle assembly (10) can be used as a fuel injector for a gas turbine engine, with jet fuel being supplied to the first circuit during start-up and low power conditions and jet fuel being supplied to both the first circuit and the second circuit during high power conditions.

Abstract: A magnetic holding device includes a hollow cylinder having closed ends. A rodless piston is slidable within the cylinder for movement between the ends. A magnet is carried by the piston. The piston is driven back and forth in the cylinder by air pressure. The magnet is adapted to pick up a workpiece adjacent to one end of the cylinder when the piston is driven toward that end of the cylinder.

Abstract: A process is provided for the polymerization of olefins in the gas phase wherein olefins are contacted with a catalyst system consisting of an active solid hydrocarbon having been prepared by forming a pulverulent composition by mixing a transition metal component, a porous organic or inorganic solid support and an organometallic compound of the organo-Al, organo-Mg or organo-Zn type, and polymerizing a controlled amount of one or more C.sub.2 to C.sub.12 olefins in the gas phase in contact with the pulverulent composition with a specific hourly conversion of the olefins to produce the active solid hydrocarbon.

Abstract: Process for the preparation of an active solid hydrocarbon which can be used to polymerize olefines.This process comprises forming a pulverulent composition by mixing a transition metal component, a porous organic or inorganic solid support and an organometallic compound of the organo-Al, organo-Mg or organo-Zn type, and polymerizing a controlled amount of one or more C.sub.2 to C.sub.12 olefines in the gas phase in contact with the pulverulent composition with a specific hourly conversion of the olefines to produce the active solid hydrocarbon.The above active solid hydrocarbon can be used, by itself or together with an organometallic cocatalyst, as a catalytic system for polymerization of olefines, in particular in the gas phase.

Abstract: A reactor for nitration of saturated hydrocarbons having less than five con atoms, alone or in admixture, in the gaseous phase under pressure is made up of a reaction enclosure, in which a tube or pipe bank is in contact with a heated fluid of high heat-exchange capacity. The inside perimeter of the tubes does not exceed 800 mm, and if circular not in excess of 250 mm, and the ratio of the surface of the tube bank, in contact with the reaction medium, to the volume of the reaction enclosure is 1:1 to 3:1.The reactor apparatus further includes a mechanical means to uniformly distribute the delivery of reaction medium gases to the various tubes of the bank so that the load difference between the most loaded tube and that of the least loaded tube is equal to 10% at the most.The reactor also includes a tube bank injector which feeds the tube bank to assure homogeneous mixing of all the reaction fluids in the tube bank.

Abstract: A reactor for nitration of saturated hydrocarbons having less than five con atoms, alone or in admixture, in the gaseous phase under pressure is made up of a reaction enclosure, in which a tube or pipe bank is in contact with a heated fluid of high heat-exchange capacity. The inside perimeter of the tubes does not exceed 800 mm, and if circular not in excess of 250 mm, and the ratio of the surface of the tube bank, in contact with the reaction medium, to the volume of the reaction enclosure is 1:1 to 3:1.The reactor apparatus further includes a mechanical means to uniformly distribute the delivery of reaction medium gases to the various tubes of the bank so that the load difference between the most loaded tube and that of the least loaded tube is equal to 10% at the most.The reactor also includes a tube bank injector which feeds the tube bank to assure homogeneous mixing of all the reaction fluids in the tube bank.

Abstract: The invention relates to a process for polymerizing in an aqueous phase using heterogeneous catalysis and to a spherical reactor for carrying out said process. At least one monomer which is gaseous under the reaction conditions is just in contact with a solid catalyst in an agitated polymerization zone. The polymerization zone is defined by a spherical wall and the agitation is effected by means of a turbine unit having blades driven in rotation. The blades extend alongside the wall on 10 to 60% of its surface. The particles of the catalyst and the growing polymer powder are driven by centrifugal force onto at least a part of the spherical wall and fall back into the central part of the spherical zone, thereby ensuring a thorough and uniform mixing without any dead zone. The invention is useful for prepolymerizing or polymerizing olefins.

Abstract: Locking device for securing cargo in containers or pallets, comprising two latches hinged together and hinged to the locking device frame, one by a fixed hinge pin and the other by a hinge pin which can move in translation.The latches are constantly acted on by a spring which draws them into the cargo locking position, in which the latches project up above the frame, by a spring and are changed over, by downwards pressure on the latches, to the cargo unlocking position, in which they are retracted.

Abstract: A lock for stowage of freight in a vehicle includes two latches pivotally mounted transversely between two supporting spars and provided with anchor flanges for the freight. The latches are pivotable between open and closed positions. The lock includes a manual locking member mounted to be able to rotate about the pivot axis of the two latches, one latch cooperating with a locking lever which is able to rock about a transverse pivot fixed to the spars. The latches have bearing surfaces which cooperate with the locking member in the open and closed positions. The lock in accordance with the invention is specially applicable to the stowage of freight in the bays of freight aircraft.