Patents by Inventor Robert Perry BRAKE

Robert Perry BRAKE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for Reduced Aggregate Formation in Downstream Processing of Bispecific Antigen-Binding Molecules
    Publication number: 20220396599
    Abstract: The present disclosure provides a downstream manufacturing method for the production of bispecific antigen-binding molecule products, which comprise at least two different binding domains. The process comprises at least one filtration step, wherein the filtration is ultrafiltration/diafiltration (UF/DF), and/or viral filtration (VF), wherein a ?-cyclodextrin is applied in the process either in a buffer applied in the filtration step or added to the filtration pool after the UF/DF filtration step wherein the buffer or the pool have a concentration of about 0.1 to 3% (m/v) of a (3-cyclodextrin, to preferably keep the product in a non-aggregated form.
    Type: Application
    Filed: November 13, 2020
    Publication date: December 15, 2022
    Inventors: Yan Wang, Nicholas Marchand, Robert Perry Brake, Maria Perry, Ashish Sharma, Eugene Sun
  • Removal of leaked affinity purification ligand
    Patent number: 11492372
    Abstract: The invention provides for the removal of a large fraction of contaminants from protein preparations while maintaining a high level of recovery using tentacle anion exchange matrix chromatography medium. Using the methods of the invention, leached affinity chromatography contaminants can be removed from recombinant protein preparations.
    Type: Grant
    Filed: December 17, 2021
    Date of Patent: November 8, 2022
    Assignee: AMGEN INC.
    Inventors: Samuel Ray Trejo, Robert Perry Brake
  • REMOVAL OF LEAKED AFFINITY PURIFICATION LIGAND
    Publication number: 20220144886
    Abstract: The invention provides for the removal of a large fraction of contaminants from protein preparations while maintaining a high level of recovery using tentacle anion exchange matrix chromatography medium. Using the methods of the invention, leached affinity chromatography contaminants can be removed from recombinant protein preparations.
    Type: Application
    Filed: December 17, 2021
    Publication date: May 12, 2022
    Applicant: AMGEN INC.
    Inventors: Samuel Ray TREJO, Robert Perry BRAKE
  • Removal of leaked affinity purification ligand
    Patent number: 11192919
    Abstract: The invention provides for the removal of a large fraction of contaminants from protein preparations while maintaining a high level of recovery using tentacle anion exchange matrix chromatography medium. Using the methods of the invention, leached affinity chromatography contaminants can be removed from recombinant protein preparations.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: December 7, 2021
    Assignee: AMGEN INC.
    Inventors: Samuel Ray Trejo, Robert Perry Brake
  • REMOVAL OF LEAKED AFFINITY PURIFICATION LIGAND
    Publication number: 20190085021
    Abstract: The invention provides for the removal of a large fraction of contaminants from protein preparations while maintaining a high level of recovery using tentacle anion exchange matrix chromatography medium. Using the methods of the invention, leached affinity chromatography contaminants can be removed from recombinant protein preparations.
    Type: Application
    Filed: July 23, 2018
    Publication date: March 21, 2019
    Applicant: AMGEN INC.
    Inventors: Samuel Ray TREJO, Robert Perry BRAKE
  • REMOVAL OF LEAKED AFFINITY PURIFICATION LIGAND
    Publication number: 20160024144
    Abstract: The invention provides for the removal of a large fraction of contaminants from protein preparations while maintaining a high level of recovery using tentacle anion exchange matrix chromatography medium. Using the methods of the invention, leached affinity chromatography contaminants can be removed from recombinant protein preparations.
    Type: Application
    Filed: March 11, 2014
    Publication date: January 28, 2016
    Applicant: AMGEN INC.
    Inventors: Samuel Ray TREJO, Robert Perry BRAKE