Patents by Inventor Robert Peter Gale

Robert Peter Gale has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents
    Patent number: 7964583
    Abstract: The present disclosure relates to salts and compositions of isophosphoramide mustard and isophosphoramide mustard analogs. In one embodiment the salts can be represented by the formula wherein A+ represents an ammonium species selected from the protonated (conjugate acid) or quaternary forms of aliphatic amines and aromatic amines, including basic amino acids, heterocyclic amines, substituted and unsubstituted pyridines, guanidines and amidines; and X and Y independently represent leaving groups. Also disclosed herein are methods for making such compounds and formulating pharmaceutical compositions thereof. Methods for administering the disclosed compounds to subjects, particularly to treat hyperproliferative disorders, also are disclosed.
    Type: Grant
    Filed: February 20, 2007
    Date of Patent: June 21, 2011
    Assignee: Ziopharm Oncology, Inc.
    Inventor: Robert Peter Gale
  • SALTS OF ISOPHOSPHORAMIDE MUSTARD AND ANALOGS THEREOF AS ANTI-TUMOR AGENTS
    Publication number: 20110118209
    Abstract: The present disclosure relates to salts and compositions of isophosphoramide mustard and isophosphoramide mustard analogs. In one embodiment the salts can be represented by the formula wherein A+ represents an ammonium species selected from the protonated (conjugate acid) or quaternary forms of aliphatic amines and aromatic amines, including basic amino acids, heterocyclic amines, substituted and unsubstituted pyridines, guanidines and amidines; and X and Y independently represent leaving groups. Also disclosed herein are methods for making such compounds and formulating pharmaceutical compositions thereof. Methods for administering the disclosed compounds to subjects, particularly to treat hyperproliferative disorders, also are disclosed.
    Type: Application
    Filed: February 20, 2007
    Publication date: May 19, 2011
    Applicant: ZIOPHARM Oncology, Inc.
    Inventor: Robert Peter Gale
  • Combination Chemotherapy Comprising A Liposomal Platinum Complex
    Publication number: 20080107721
    Abstract: The present invention relates to methods for treating cancer comprising administering a combination of a liposomal platinum complex and one or more additional anticancer agents, pharmaceutical compositions comprising a liposomal platinum complex and one or more additional anticancer agents, and kits comprising unit doses of a liposomal platinum complex and one or more additional anticancer agents.
    Type: Application
    Filed: May 20, 2003
    Publication date: May 8, 2008
    Inventors: Jonathan Lewis, Axel Hoos, Robert Peter Gale
  • Combination Chemotherapy Comprising 5-Fluorouracil or a Derivative Thereof and a Liposomal Platinum Complex
    Publication number: 20080050425
    Abstract: The present invention relates to methods for treating cancer comprising administering a combination of 5-fluorouracil or a derivative thereof and a liposomal platinum complex. Pharmaceutical compositions comprising 5-fluorouracil or a derivative thereof and a liposomal platinum complex, and kits comprising unit doses of 5-fluorouracil or a derivative thereof and liposomal platinum complex.
    Type: Application
    Filed: May 20, 2003
    Publication date: February 28, 2008
    Inventors: Jonathan Lewis, Axel Hoos, Robert Peter Gale
  • Combination Chemotherapy Comprising Capecitabine and a Liposomal Platinum Complex
    Publication number: 20080026044
    Abstract: The present invention relates to methods for treating cancer comprising administering a combination of capecitabine and a liposomal platinum complex, pharmaceutical compositions comprising capecitabine and a liposomal platinum complex, and kits comprising unit dosage forms of capecitabine and a liposomal platinum complex.
    Type: Application
    Filed: May 20, 2003
    Publication date: January 31, 2008
    Inventors: Jonathan Lewis, Axel Hoos, Robert Peter Gale
  • Combination Chemotherapy Comprising a Gemcitabine and a Liposomal Platium Complex
    Publication number: 20080026045
    Abstract: The present invention relates to methods for treating cancer comprising administering a combination of gemcitabine and a liposomal platinum complex, pharmaceutical compositions comprising gemcitabine and a liposomal platinum complex, and kits comprising unit dosage forms of gemcitabine and a liposomal platinum complex.
    Type: Application
    Filed: May 20, 2003
    Publication date: January 31, 2008
    Inventors: Jonathan Lewis, Axel Hoos, Robert Peter Gale