Abstract: The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.

Abstract: The present disclosure generally relates to extrusion die systems. In particular, the present disclosure relates to the cyclical extrusion of materials to generate small sized grain features, generally in the range of nanosized grain features, in a tubular or profile shape, in which the individual nanolayers possess pores and/or polymer crystals oriented parallel to the extrusion flow direction and including products with enhanced permeation properties.

Abstract: Embodiments are directed to generating service offerings based on associated content and historical data. Content from a content panel may be provided. Subjects associated with the content may be determined based on information included in the content. A service category associated with the subjects may be determined based on services provided by a healthcare organization. An offering model may be employed to generate an offering panel based on the service category. The offering model may be evaluated based on monitoring interactions between users and the offering panel. Results of the evaluation may be employed to perform further actions including: designating the offering model for retraining based on the performance metrics; retraining the designated offering model; employing the retrained offering model to generate other offering panels for display to the users; or the like.

Abstract: A heat extraction system for extracting heat from a reservoir, the system including a co-axial tool configured to be placed underground, the co-axial tool having an outer pipe and an inner pipe located within the outer pipe, each of the outer pipe and the inner pipe being connected to a shoe so that a fluid flows through an annulus defined by the inner and outer pipes, reaches the shoe, and flows through a bore of the inner pipe; and a power generator fluidly connected to a chemical processing unit to receive a fluid, and also fluidly connected with a first port to the inner pipe and with a second port to the outer pipe of the co-axial tool. A temperature difference of the fluid at the power generator and at the co-axial tool drives the power generator to generate energy.

Abstract: Methods for processing a hydrocarbon feedstock may include cracking at least a portion of the hydrocarbon feedstock by contacting the hydrocarbon feedstock with a modified zeolite in the presence of hydrogen to form an intermediate cracked product and steam cracking at least a portion of the intermediate cracked product to form a steam cracked product. The intermediate cracked product may include at least 30 wt. % of one or more linear alkanes. The modified zeolite may include a microporous framework. The microporous framework may include at least silicon atoms and oxygen atoms. The modified zeolite also includes a plurality of Group 4-6 metal atoms each bonded to four bridging oxygen atoms, wherein each of the bridging oxygen atoms bonded to the Group 4-6 metal atoms bridges one of the plurality of the Group 4-6 metal atoms and a silicon atom of the microporous framework.

Abstract: Modified zeolites may include a microporous framework including a plurality of micropores having diameters of less than or equal to 2 nm. The microporous framework may include at least silicon atoms and oxygen atoms. The modified zeolite may include a plurality of mesopores having diameters of greater than 2 nm and less than or equal to 50 nm, wherein the plurality of mesopores are ordered with cubic symmetry. The modified zeolite may include a plurality of titanium atoms each bonded to four bridging oxygen atoms, wherein each of the bridging oxygen atoms bonded to the titanium atoms bridges one of the plurality of the titanium atoms and a silicon atom of the microporous framework.

Abstract: A functionalized fibrous hierarchical zeolite includes a framework comprising aluminum atoms, silicon atoms, and oxygen atoms, the framework further comprising a plurality of micropores and a plurality of mesopores. The functionalized fibrous hierarchical zeolite is functionalized with at least one amine. A plurality of nanoparticles comprising platinum are immobilized on the framework.

Abstract: A flow therapy apparatus can provide a hypoxic flow of gases to a user, for altitude training, athletic performance training, and other indications. The system can include an apparatus that can include a gas conduit, an ambient air inlet, and a hypoxic gas source inlet configured to connect to a hypoxic gas source and configured to create a hypoxic gas composition upon mixing of ambient air and the hypoxic gas. The system can also include a user interface, and a gas flow generation element configured to deliver the hypoxic gas composition to nares of the user at a predetermined flow rate of at least about 10 liters/minute. Methods are also disclosed.

Abstract: A functionalized fibrous hierarchical zeolite includes a framework comprising aluminum atoms, silicon atoms, and oxygen atoms, the framework further comprising a plurality of micropores and a plurality of mesopores. The functionalized fibrous hierarchical zeolite is functionalized with at least one terminal amine bonded to a silicon atom. Terminal organometallic functionalities are bonded to a nitrogen atom of the at least one terminal amine, the terminal organometallic functionalities comprising a platinum atom.

Abstract: The present invention relates to a spray dried plasma composition having one or more of the following characteristics: when reconstituted, largely amorphous and has no cholesterol crystals; when reconstituted, the number of large particulates is reduced; has low residual moisture; reconstitutes rapidly in under four minutes; highly stable when stored under refrigeration, at room temperature or at elevated temperatures and allows for storage for longer periods of time; when reconstituted, exhibits recovery of the most fragile of proteins, including von Willebrand's factor; when reconstituted with Sterile Water for Injection (SWFI), reconstituted plasma is at a pH that is near normal plasma pH, and does so without treatment or storage in CO2 or other pH adjustment; and when reconstituted, has reduced complement activation (C5A, C3A).

Abstract: A supportive clothing article is provided for a wearable cardioverter defibrillator (WCDA belt includes a first end with a first portion of a fastener and a second end with a second portion of the fastener. The belt is structured to fasten around the torso of patient below the chest area of the patient. The belt includes a first conductive mesh portion adjacent the first end of the belt or the second end of the belt, two straps. A back portion extends from the belt at an intermediary position on the belt to each of the two straps. The back portion includes a conductive mesh, a first support receptacle attached to and extending from the belt and attachable to one of the two straps, and a second support receptacle attached to and extending from the belt and attachable to the other of the two straps.

Abstract: A functionalized fibrous hierarchical zeolite includes a framework comprising aluminum atoms, silicon atoms, and oxygen atoms, the framework further comprising a plurality of micropores and a plurality of mesopores. The functionalized fibrous hierarchical zeolite is functionalized with at least one amine. A plurality of nanoparticles comprising nickel are immobilized on the framework.

Abstract: The present disclosure provides systems and methods for disease assessments. In some examples, the present disclosure provides a method for processing or analyzing a bodily sample of a subject. The method may comprise analyzing said bodily sample to yield a data set comprising at least one genetic polymorphism in the bodily sample. The at least one genetic polymorphism may be associated with a pulmonary or respiratory disease or disorder. The method may further comprise computer processing the data set and a clinical health parameter of the subject to determine a risk-value of the pulmonary or respiratory disease or disorder in the subject. The method may further comprise electronically outputting a report that identifies the risk-value of the pulmonary or respiratory disease or disorder in the subject.

Abstract: Modified zeolites may include a microporous framework including a plurality of micropores having diameters of less than or equal to 2 nm. The microporous framework may include at least silicon atoms and oxygen atoms. The modified zeolite may include a plurality of mesopores having diameters of greater than 2 nm and less than or equal to 50 nm, wherein the plurality of mesopores are ordered with cubic symmetry. The modified zeolite may include a plurality of titanium hydride moieties each bonded to at least two bridging oxygen atoms, wherein a titanium atom of the titanium hydride is bonded to the bridging oxygen atom, and wherein the bridging oxygen atom bridges the titanium atom of the titanium hydride moiety and a silicon atom of the microporous framework.

Abstract: Modified zeolites may include a microporous framework including a plurality of micropores having diameters of less than or equal to 2 nm. The microporous framework may include at least silicon atoms and oxygen atoms. The modified zeolite may include a plurality of mesopores having diameters of greater than 2 nm and less than or equal to 50 nm, wherein the plurality of mesopores are ordered with cubic symmetry. The modified zeolite may include a plurality of zirconium hydride moieties each bonded to at least two bridging oxygen atoms, wherein a zirconium atom of the zirconium hydride is bonded to the bridging oxygen atom, and wherein the bridging oxygen atom bridges the zirconium atom of the zirconium hydride moiety and a silicon atom of the microporous framework.

Abstract: Described herein are zeolite Beta particles with radially arranged mesopores and methods of making the same. In one or more embodiments, a zeolite Beta particle may include a Beta zeolitic framework including a plurality of micropores having diameters of less than or equal to 2 nm. In embodiments, the Beta zeolitic framework may include alumina and silica. In embodiments, the zeolite Beta particles disclosed herein may include a plurality of mesopores having diameters of greater than 2 nm and less than or equal to 50 nm. In embodiments, the plurality of mesopores may be arranged in a center-radial configuration, such that mesopores run from a central region of the zeolite Beta particle towards the edge of the zeolite Beta particle.

Abstract: Modified zeolites may include a microporous framework including a plurality of micropores having diameters of less than or equal to 2 nm. The microporous framework may include at least silicon atoms and oxygen atoms. The modified zeolite may include a plurality of mesopores having diameters of greater than 2 nm and less than or equal to 50 nm, wherein the plurality of mesopores are ordered with cubic symmetry. The modified zeolite may include a plurality of hafnium hydride moieties each bonded to at least two bridging oxygen atoms, wherein a hafnium atom of the hafnium hydride is bonded to the bridging oxygen atom, and wherein the bridging oxygen atom bridges the hafnium atom of the hafnium hydride moiety and a silicon atom of the microporous framework.

Abstract: A system and method including providing a feed having alkyl-bridged multi-aromatic compounds to a tubular reactor, heating the tubular reactor, and cleaving an alkyl bridge of the alkyl-bridged multi-aromatic compounds.

Abstract: Disclosed herein are amine functionalized zeolites and methods for making amine functionalized zeolites. In one or more embodiments disclosed herein, an amine functionalized zeolite may include a microporous framework including a plurality of micropores having diameters of less than or equal to 2 nm. The microporous framework may include at least silicon atoms and oxygen atoms. The amine functionalized zeolite may further include a plurality of mesopores having diameters of greater than 2 nm and less than or equal to 50 nm and one or more of isolated terminal primary amine functionalities bonded to silicon atoms of the microporous framework or silazane functionalities, where the nitrogen atom of the silazane bridges two silicon atoms of the microporous framework.

Abstract: Systems and techniques are described herein for processing image data. For instance, a method for processing image data is provided. The method may include capturing an image; determining at least one region of interest of the image based on at least one of object recognition, object tracking, hand tracking, semantic segmentation, saliency detection, or computer vision; encoding a first portion of the image according to a first parameter to generate first encoded data, the first portion of the image corresponding to the at least one region of interest; encoding a second portion of the image according to a second parameter to generate second encoded data; and transmitting, to a computing device, the first encoded data and the second encoded data.