Abstract: A hydrocracking catalyst comprises an active cracking support. The active cracking support comprises a post-modified zeolite framework having zirconium atoms and titanium atoms substituting for aluminum atoms; wherein: a portion of the zirconium atom are substituted in the post-modified zeolite via 4-coordination; a portion of the zirconium atom are grafted to the post-modified zeolite via 5-coordination; and the titanium atoms are substituted in the post-modified zeolite framework via 4-coordination.

Abstract: A heat extraction system for extracting heat from a reservoir, the system including a co-axial tool configured to be placed underground, the co-axial tool having an outer pipe and an inner pipe located within the outer pipe, each of the outer pipe and the inner pipe being connected to a shoe so that a fluid flows through an annulus defined by the inner and outer pipes, reaches the shoe, and flows through a bore of the inner pipe; and a power generator fluidly connected to a chemical processing unit to receive a fluid, and also fluidly connected with a first port to the inner pipe and with a second port to the outer pipe of the co-axial tool. A temperature difference of the fluid at the power generator and at the co-axial tool drives the power generator to generate energy.

Abstract: The present disclosure provides to graphical user interfaces for controlling a flow therapy apparatus. The graphical user interface can provide a display of flow therapy treatment information and indicators of a patient's health. The graphical user interface can be configured to display the information associated with the patient on one or more user interface screens.

Abstract: The present invention relates to a spray dried plasma composition having one or more of the following characteristics: when reconstituted, largely amorphous and has no cholesterol crystals; when reconstituted, the number of large particulates is reduced; has low residual moisture; reconstitutes rapidly in under four minutes; highly stable when stored under refrigeration, at room temperature or at elevated temperatures and allows for storage for longer periods of time; when reconstituted, exhibits recovery of the most fragile of proteins, including von Willebrand's factor; when reconstituted with Sterile Water for Injection (SWFI), reconstituted plasma is at a pH that is near normal plasma pH, and does so without treatment or storage in CO2 or other pH adjustment; and when reconstituted, has reduced complement activation (C5A, C3A).

Abstract: A device for producing a 3D-printed active substance-releasing system with active substance depots, such that a radiation source in operation causes a polymerisation of a layer of the base material on the construction platform and that an inkjet printhead incorporates an active substance mixture, which has at least one active substance, into the base material in a locationally selective manner. A trough is provided, in which a base material and a construction platform are arranged, and polymerising selected regions of a layer of the base material on the construction platform and introducing, by means of an inkjet printing method, an active substance mixture, which has at least one active substance, into the base material and/or polymerised base material in a locationally selective manner in order to thereby create active ingredient depots in the active ingredient-releasing system.

Abstract: A drill bit for drilling a borehole in an earthen formation has a central axis and a cutting direction of rotation. The bit includes a bit body configured to rotate about the axis in the cutting direction of rotation. The bit body includes a bit face. The bit also includes a blade extending radially along the bit face. In addition, the bit includes a first cutter element mounted to a cutter-supporting surface of the blade and a second cutter element mounted to the cutter-supporting surface of the blade. The first cutter element has a central axis and includes a first forward-facing cutting face including a first cutting tip distal the cutter supporting surface and a first planar surface extending radially from the first cutting tip toward the central axis of the first cutter element. The first planar surface is oriented at a first effective backrake angle measured between the cutter supporting surface and a surface vector of the first planar surface.

Abstract: Modified zeolite may include a microporous framework including a plurality of micropores having diameters of less than or equal to 2 nm, wherein the microporous framework includes at least silicon atoms and oxygen atoms; a plurality of mesopores having diameters of greater than 2 nm and less than or equal to 50 nm, wherein the plurality of mesopores are ordered with cubic symmetry. The modified zeolite also includes: isolated terminal primary amine functionalities bonded to silicon atoms of the microporous framework; or silazane functionalities, wherein the nitrogen atom of the silazane bridges two silicon atoms of the microporous framework; or both.

Abstract: A system for collecting tissue samples, such as meat tissues on carcasses, for example in the food industry. Also provided are methods for collecting tissue samples, and to a non-transitory computer-readable medium comprising program instructions to execute at least one step of the method for collecting tissue samples.

Abstract: The disclosure relates to a safeguarding module, a method, and a system for safeguarding an apparatus in the medical environment against an unauthorised operation of the apparatus, wherein the authorisation is dependent upon a linking event between two linking partners within the framework of an operation of the apparatus, wherein the apparatuses are connected via a network, and wherein one of the linking partners is an item which is used during the operation of the apparatus. The system comprises a plurality of apparatuses, wherein in each case an apparatus comprises a safeguarding module, comprising: a read-in interface for reading-in a first identifier and a second identifier; a processing unit which is designed to perform the safeguarding method; a memory for storing the calculated documentation value in a distributed ledger structure; and an interface to the network, via which the apparatuses exchange data.

Abstract: The present disclosure generally relates to extrusion die systems. In particular, the present disclosure relates to the cyclical extrusion of materials to generate small sized grain features, generally in the range of nanosized grain features, in a tubular or profile shape, in which the individual nanolayers possess pores and/or polymer crystals oriented parallel to the extrusion flow direction and including products with enhanced permeation properties.

Abstract: The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.

Abstract: Embodiments are directed to generating service offerings based on associated content and historical data. Content from a content panel may be provided. Subjects associated with the content may be determined based on information included in the content. A service category associated with the subjects may be determined based on services provided by a healthcare organization. An offering model may be employed to generate an offering panel based on the service category. The offering model may be evaluated based on monitoring interactions between users and the offering panel. Results of the evaluation may be employed to perform further actions including: designating the offering model for retraining based on the performance metrics; retraining the designated offering model; employing the retrained offering model to generate other offering panels for display to the users; or the like.

Abstract: A heat extraction system for extracting heat from a reservoir, the system including a co-axial tool configured to be placed underground, the co-axial tool having an outer pipe and an inner pipe located within the outer pipe, each of the outer pipe and the inner pipe being connected to a shoe so that a fluid flows through an annulus defined by the inner and outer pipes, reaches the shoe, and flows through a bore of the inner pipe; and a power generator fluidly connected to a chemical processing unit to receive a fluid, and also fluidly connected with a first port to the inner pipe and with a second port to the outer pipe of the co-axial tool. A temperature difference of the fluid at the power generator and at the co-axial tool drives the power generator to generate energy.

Abstract: Methods for processing a hydrocarbon feedstock may include cracking at least a portion of the hydrocarbon feedstock by contacting the hydrocarbon feedstock with a modified zeolite in the presence of hydrogen to form an intermediate cracked product and steam cracking at least a portion of the intermediate cracked product to form a steam cracked product. The intermediate cracked product may include at least 30 wt. % of one or more linear alkanes. The modified zeolite may include a microporous framework. The microporous framework may include at least silicon atoms and oxygen atoms. The modified zeolite also includes a plurality of Group 4-6 metal atoms each bonded to four bridging oxygen atoms, wherein each of the bridging oxygen atoms bonded to the Group 4-6 metal atoms bridges one of the plurality of the Group 4-6 metal atoms and a silicon atom of the microporous framework.

Abstract: Modified zeolites may include a microporous framework including a plurality of micropores having diameters of less than or equal to 2 nm. The microporous framework may include at least silicon atoms and oxygen atoms. The modified zeolite may include a plurality of mesopores having diameters of greater than 2 nm and less than or equal to 50 nm, wherein the plurality of mesopores are ordered with cubic symmetry. The modified zeolite may include a plurality of titanium atoms each bonded to four bridging oxygen atoms, wherein each of the bridging oxygen atoms bonded to the titanium atoms bridges one of the plurality of the titanium atoms and a silicon atom of the microporous framework.

Abstract: A functionalized fibrous hierarchical zeolite includes a framework comprising aluminum atoms, silicon atoms, and oxygen atoms, the framework further comprising a plurality of micropores and a plurality of mesopores. The functionalized fibrous hierarchical zeolite is functionalized with at least one amine. A plurality of nanoparticles comprising platinum are immobilized on the framework.

Abstract: A flow therapy apparatus can provide a hypoxic flow of gases to a user, for altitude training, athletic performance training, and other indications. The system can include an apparatus that can include a gas conduit, an ambient air inlet, and a hypoxic gas source inlet configured to connect to a hypoxic gas source and configured to create a hypoxic gas composition upon mixing of ambient air and the hypoxic gas. The system can also include a user interface, and a gas flow generation element configured to deliver the hypoxic gas composition to nares of the user at a predetermined flow rate of at least about 10 liters/minute. Methods are also disclosed.

Abstract: A functionalized fibrous hierarchical zeolite includes a framework comprising aluminum atoms, silicon atoms, and oxygen atoms, the framework further comprising a plurality of micropores and a plurality of mesopores. The functionalized fibrous hierarchical zeolite is functionalized with at least one terminal amine bonded to a silicon atom. Terminal organometallic functionalities are bonded to a nitrogen atom of the at least one terminal amine, the terminal organometallic functionalities comprising a platinum atom.

Abstract: The present invention relates to a spray dried plasma composition having one or more of the following characteristics: when reconstituted, largely amorphous and has no cholesterol crystals; when reconstituted, the number of large particulates is reduced; has low residual moisture; reconstitutes rapidly in under four minutes; highly stable when stored under refrigeration, at room temperature or at elevated temperatures and allows for storage for longer periods of time; when reconstituted, exhibits recovery of the most fragile of proteins, including von Willebrand's factor; when reconstituted with Sterile Water for Injection (SWFI), reconstituted plasma is at a pH that is near normal plasma pH, and does so without treatment or storage in CO2 or other pH adjustment; and when reconstituted, has reduced complement activation (C5A, C3A).

Abstract: A supportive clothing article is provided for a wearable cardioverter defibrillator (WCDA belt includes a first end with a first portion of a fastener and a second end with a second portion of the fastener. The belt is structured to fasten around the torso of patient below the chest area of the patient. The belt includes a first conductive mesh portion adjacent the first end of the belt or the second end of the belt, two straps. A back portion extends from the belt at an intermediary position on the belt to each of the two straps. The back portion includes a conductive mesh, a first support receptacle attached to and extending from the belt and attachable to one of the two straps, and a second support receptacle attached to and extending from the belt and attachable to the other of the two straps.