Abstract: The present disclosure provides novel nucleic acid-guided nucleases and methods of using the nucleases for genome editing. The present disclosure further provides a system for editing a target region in a genome comprising a nucleic acid-guided nuclease, a heterologous guide nucleic acid for complexing with the nucleic acid-guided nuclease, and an editing polynucleotide configured to bind to the target region.

Abstract: Apparatus and method for treating a substrate, for example texturing a substrate. In some embodiments, a masking material is applied to a surface of the substrate in a predetermined pattern, the surface thereafter contacted with an etchant that removes the masking material. Contacting the surface with the etchant produces multiple co-located textures. In other embodiments, the masking step can be eliminated, and the etchant is applied in a predetermined pattern to produce multiple co-located textures. In still other embodiments, the substrate has a chemical composition, and the substrate is exposed to a leachant that leaches at least one constituent of the chemical composition to produce a substrate with a varying chemical composition at the substrate surface.

Abstract: A light source system, preferably including one or more electron inputs, splitters, recombiners, and/or electron outputs, and optionally including one or more accelerator modules, input transports, radiator modules, and/or output transports. The system can optionally include one or more ancillary elements (e.g., electron optics elements). A method of operation, preferably including operating in a normal mode and/or operating in a backup mode.

Abstract: A light source system, preferably including one or more electron inputs, splitters, recombiners, and/or electron outputs, and optionally including one or more accelerator modules, input transports, radiator modules, and/or output transports. The system can optionally include one or more ancillary elements (e.g., electron optics elements). A method of operation, preferably including operating in a normal mode and/or operating in a backup mode.

Abstract: A light source system, preferably including one or more electron inputs, splitters, recombiners, and/or electron outputs, and optionally including one or more accelerator modules, input transports, radiator modules, and/or output transports. The system can optionally include one or more ancillary elements (e.g., electron optics elements). A method of operation, preferably including operating in a normal mode and/or operating in a backup mode.

Abstract: Foldable substrates have a first portion, a second portion, and a central portion positioned therebetween with a first transition region having a first central surface area of the central portion with a first average angle. In aspects, the first average angle is from about 176.10 to about 179.9° or from about 177.0° to about 179.9°. In aspects, a polymer angle is from 178.3° to about 179.9° or from about 179.10 to about 179.9°. Methods comprise disposing an etch mask over the first major surface of the foldable substrate before etching the foldable substrate. In aspects, the etch mask comprises a first polymer layer positioned between a first barrier layer and the first major surface. In aspects, the etch mask comprises a plurality of ink-jet printed shapes. Methods of measuring a contrast ratio comprise impinging a transparent apparatus with a collimated beam.

Abstract: A teeth cleaning device includes a support structure having a floor, a glossal wall, and a facial wall that collectively define a dentature channel. The floor may include first, second, and third floor portions, with the first floor portion located between the second and third floor portions. First and second floor air bladders may be located along the second and third floor portions. First and second teeth cleaning pads may be coupled to the first and second floor air bladders, respectively. The first floor portion may not have any air bladders and teeth cleaning pads therealong. An air flow subsystem may be fluidly coupled to the first and second floor air bladders.

Abstract: Systems and methods to monitor veracity of a collection of one or more profiles associated with a user.

Abstract: In one embodiment, the invention may be a teeth cleaning device including: a first support structure comprising a first dentature channel configured to receive at least a first portion of a dentature of a user; a plurality of teeth cleaning pads located within the first dentature channel; a plurality of air bladders operably coupled to the teeth cleaning pads; an air-flow subsystem operably coupled to the air bladders; and a control unit operably coupled to the air-flow subsystem, the control unit configured to: (1) pressurize the air bladders with external air in a pressurization mode; and (2) transfer air between select ones of the air bladders in a cleaning mode.

Abstract: A housing of a device comprises a screw boss that extends outwardly from a first base plate proximate to a corner of the housing. Additionally, the housing of the device includes a force dissipation member. The force dissipation member includes a central portion that is sized to detachably attach around the screw boss. The force dissipation member further includes at least two arms that extend outwardly from the central portion, wherein each arm of the at least two arms is attached to a different side of the two walls of the housing.

Abstract: The industry-standard corkscrew has numerous flaws resulting in broken corks—even in the hands of a professional. The present invention is a radical departure from the traditional corkscrew apparatus. The opener generally consists of the handle and an internally threaded half-pipe. The half-pipe slides between the cork and the bottle, wherein the series of threads engage the cork. Rotating the handle causes the threads to bore deeper into the neck of the bottle until the handles meets the lip of the bottle, and then lift the cork out of the bottle until it disengages and falls away from the opener. It should be appreciated that the elegance of the opener resides in its simplicity.

Abstract: The disclosure provides a one-way valve for coffee packaging that can be implemented on a manufacturing line. The disclosed valve has a vent pressure can be adjusted to capture maximum coffee flavor without bursting the packaging. The valve is applicable to flex coffee packs as well as single serve coffee pods.

Abstract: Existing currency validation (CVAL) devices, systems, and methods are too slow, costly, intrusive, and/or bulky to be routinely used in common transaction locations (e.g., at checkout, at an automatic teller machine, etc.). Presented herein are devices, systems, and methods to facilitate optical validation of documents, merchandise, or currency at common transaction locations and to do so in an obtrusive and convenient way. More specifically, the present invention embraces a validation device that may be used alone or integrated within a larger system (e.g., point of sale system, kiosk, etc.). The present invention also embraces methods for currency validation using the validation device, as well as methods for improving the quality and consistency of data captured by the validation device for validation.

Abstract: A latch mechanism for a child-resistant storage case has a seal bead between the lid and body of the storage case. The latch mechanism includes a latch tab extending downward from the lid that must be simultaneously pivoted inward and pressed upward to release the lid. The latch tab acts as a lever arm to locally deform the adjacent portions of the lid and seal, and thereby more easily release the seal when the latch tab is pressed upward.

Abstract: Systems and methods to monitor veracity of a collection of one or more profiles associated with a user.

Abstract: Provided herein are antibody molecules that bind specifically to VISTA and antigen-binding portions thereof and related compositions, nucleic acid molecules, vectors and host cells. Also provided herein are medical uses of such antibody molecules.

Abstract: In one embodiment, the invention may be a teeth cleaning device including: a first support structure comprising a first dentature channel configured to receive at least a first portion of a dentature of a user; a plurality of teeth cleaning pads located within the first dentature channel; a plurality of air bladders operably coupled to the teeth cleaning pads; an air-flow subsystem operably coupled to the air bladders; and a control unit operably coupled to the air-flow subsystem, the control unit configured to: (1) pressurize the air bladders with external air in a pressurization mode; and (2) transfer air between select ones of the air bladders in a cleaning mode.

Abstract: In one embodiment, the invention may be a teeth cleaning device including: a first support structure comprising a first dentature channel configured to receive at least a first portion of a dentature of a user; a plurality of teeth cleaning pads located within the first dentature channel; a plurality of air bladders operably coupled to the teeth cleaning pads; an air-flow subsystem operably coupled to the air bladders; and a control unit operably coupled to the air-flow subsystem, the control unit configured to: (1) pressurize the air bladders with external air in a pressurization mode; and (2) transfer air between select ones of the air bladders in a cleaning mode.