Patents by Inventor Robert Pitti

Robert Pitti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF TREATING CANCER AND PREVENTING CANCER DRUG RESISTANCE
    Publication number: 20170209444
    Abstract: Provided herein are methods of using antagonists of G9a, for example, for treating cancer and/or preventing drug resistance in an individual. For example, a method of treating cancer in an individual comprising administering to the individual an antagonist of G9a alone or in combination with a cancer therapy agent is provided. In some embodiments, the antagonist of G9a increases the period of cancer sensitivity and/or delays development of cancer resistance.
    Type: Application
    Filed: June 23, 2015
    Publication date: July 27, 2017
    Applicant: Genentech Inc.
    Inventors: Marie Classon, Gulfem Dilek Guler, Robert Pitti, Jean-Philippe Stephan, Charles Albert Tindell
  • DcR3 polypeptide, A TNFR homolog
    Publication number: 20100080793
    Abstract: A TNFR homolog, identified as DcR3, is provided. Nucleic acid molecules encoding DcR3, chimeric molecules and antibodies to DcR3 are also provided.
    Type: Application
    Filed: October 14, 2008
    Publication date: April 1, 2010
    Applicant: Genentech, Inc.
    Inventors: Avi J. Ashkenazi, David Botstein, Kelly H. Dodge, Audrey Goddard, Austin L. Gurney, Kyung Jim Kim, David A. Lawrence, Robert Pitti, Margaret A. Roy, Daniel B. Tumas, William I. Wood
  • DcR3 polypeptide, A TNFR homolog
    Publication number: 20090191184
    Abstract: A TNFR homolog, identified as DcR3, is provided. Nucleic acid molecules encoding DcR3, chimeric molecules and antibodies to DcR3 are also provided.
    Type: Application
    Filed: October 14, 2008
    Publication date: July 30, 2009
    Applicant: Genentech, Inc.
    Inventors: Avi J. Ashkenazi, David Botstein, Kelly H. Dodge, Audrey Goddard, Austin L. Gurney, Kyung Jin Kim, David A. Lawrence, Robert Pitti, Margaret A. Roy, Daniel B. Tumas, William I. Wood
  • Apo-3 ligand polypeptide
    Publication number: 20080213837
    Abstract: A tumor necrosis factor and lymphotoxin homolog having apoptotic activity, identified as Apo-3 Ligand, is provided. Nucleic acid molecules encoding Apo-3 Ligand, chimeric molecules and antibodies to Apo-3 Ligand are also provided.
    Type: Application
    Filed: October 30, 2007
    Publication date: September 4, 2008
    Applicant: Genentech, Inc.
    Inventors: Avi J. Ashkenazi, Scot A. Marsters, Robert Pitti
  • Apo-3 ligand polypeptide
    Publication number: 20080171037
    Abstract: A tumor necrosis factor and lymphotoxin homolog having apoptotic activity, identified as Apo-3 Ligand, is provided. Nucleic acid molecules encoding Apo-3 Ligand, chimeric molecules and antibodies to Apo-3 Ligand are also provided.
    Type: Application
    Filed: August 7, 2007
    Publication date: July 17, 2008
    Inventors: Avi J. Ashkenazi, Scot A. Marsters, Robert Pitti
  • Novel cycloalkyl derivatives as inhibitors of bone resorption and vitronectin receptor antagonists
    Publication number: 20080021055
    Abstract: There are described cycloalkyl derivatives of the formula (I) R1—Y-A-B-D-E-F-G ??(I) in which R1, Y, A, B, D, E, F and G have the meaning indicated herein, their preparation and their use as medicaments. The compounds according to the invention can be used as vitronectin receptor antagonists and as inhibitors of bone resorption.
    Type: Application
    Filed: August 21, 2007
    Publication date: January 24, 2008
    Inventors: Volkmar Wehner, Jochen Knolle, Hans Stilz, Jean-Francois Gourvest, Denis Carniato, Thomas Gadek, Robert McDowell, Robert Pitti, Sarah Bodary
  • DNA19355 polypeptide, a tumor necrosis factor homolog
    Publication number: 20070072263
    Abstract: A tumor necrosis factor homolog, identified as DNA19355, is provided. DNA19355 polypeptide has apoptotic activity in mammalian cancer cells and may be involved in proinflammatory responses. Nucleic acid molecules encoding DNA19355, chimeric molecules and antibodies to DNA19355 are also provided.
    Type: Application
    Filed: May 6, 2005
    Publication date: March 29, 2007
    Inventors: Avi Ashkenazi, Kevin Baker, Paul Godowski, Austin Gurney, Melanie Mark, Scot Marsters, Robert Pitti
  • Method for treating tumors using anti-osteopontin antibodies
    Publication number: 20070041983
    Abstract: The present invention is directed to compositions of matter useful for the treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: September 28, 2006
    Publication date: February 22, 2007
    Applicant: Genentech, Inc.
    Inventors: Avi Ashkenazi, Robert Pitti, Thomas Wu, Zemin Zhang
  • DNA 19355 polypeptide, a tumor necrosis factor homolog
    Publication number: 20060216270
    Abstract: A tumor necrosis factor homolog, identified as DNA19355, is provided. DNA19355 polypeptide has apoptotic activity in mammalian cancer cells and may be involved in proinflammatory responses. Nucleic acid molecules encoding DNA19355, chimeric molecules and antibodies to DNA19355 are also provided.
    Type: Application
    Filed: February 14, 2006
    Publication date: September 28, 2006
    Applicant: Genentech, Inc.
    Inventors: Avi Ashkenazi, Kevin Baker, Paul Godowski, Austin Gurney, Melanie Mark, Scot Marsters, Robert Pitti
  • Novel tumor necrosis factor receptor homolog and nucleic acids encoding the same
    Publication number: 20060141573
    Abstract: The present invention is directed to novel polypeptides having homology to members of the tumor necrosis factor receptor family and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: December 22, 2005
    Publication date: June 29, 2006
    Applicant: Genentech, Inc.
    Inventors: Avi Ashkenazi, Audrey Goddard, Austin Gurney, Scot Marsters, Robert Pitti, William Wood
  • Uses of agonists and antagonists to modulate activity of TNF-related molecules
    Publication number: 20060073146
    Abstract: Methods of using one or more agonists or antagonists to modulate activity of the members of the TNF and TNFR families referred to as TALL-1, APRIL, TACI, and BCMA are provided. The methods include in vitro, in situ, and/or in vivo diagnosis and/or treatment of mammalian cells or pathological conditions associated with TALL-1, APRIL, TACI, or BCMA, using one or more agonist or antagonist molecules. The methods of treatment disclosed by the invention include methods of treating immune related diseases and cancer.
    Type: Application
    Filed: February 28, 2005
    Publication date: April 6, 2006
    Inventors: Avi Ashkenazi, Kelly Dodge, Iqbal Grewal, Kyung Kim, Scot Marsters, Robert Pitti, Minhong Yan
  • Method for treating tumors using anti-osteopontin antibodies
    Publication number: 20050226868
    Abstract: The present invention is directed to compositions of matter useful for the treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: October 13, 2004
    Publication date: October 13, 2005
    Inventors: Avi Ashkenazi, Robert Pitti, Thomas Wu, Zemin Zhang
  • Novel tumor necrosis factor receptor homolog and nucleic acids encoding the same
    Publication number: 20050069983
    Abstract: The present invention is directed to novel polypeptides having homology to members of the tumor necrosis factor receptor family and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: October 6, 2004
    Publication date: March 31, 2005
    Inventors: Avi Ashkenazi, Audrey Goddard, Austin Gurney, Scot Marsters, Robert Pitti, William Wood
  • DcR3 polypeptide, a TNFR homolog
    Publication number: 20040231011
    Abstract: A TNFR homolog, identified as DcR3, is provided. Nucleic acid molecules encoding DcR3, chimeric molecules and antibodies to DcR3 are also provided.
    Type: Application
    Filed: June 17, 2004
    Publication date: November 18, 2004
    Applicant: Genentech, Inc.
    Inventors: Avi J. Ashkenazi, David Botstein, Kelly H. Dodge, Audrey Goddard, Austin L. Gurney, Kyung Jin Kim, David A. Lawrence, Robert Pitti, Margaret A. Roy, Daniel B. Tumas, William I. Wood
  • DcR3 polypeptide, a TNFR homolog
    Publication number: 20040175791
    Abstract: A TNFR homolog, identified as DcR3, is provided. Nucleic acid molecules encoding DcR3, chimeric molecules and antibodies to DcR3 are also provided.
    Type: Application
    Filed: October 17, 2003
    Publication date: September 9, 2004
    Applicant: Genentech, Inc.
    Inventors: Avi J. Ashkenazi, David Botstein, Kelly H. Dodge, Audrey Goddard, Austin L. Gurney, Kyung Jin Kim, David A. Lawrence, Robert Pitti, Margaret A. Roy, Daniel B. Tumas, William I. Wood
  • Antibodies to DcR3 Polypeptide, a TNFR Homolog
    Patent number: 6764679
    Abstract: A TNFR homolog, identified as DcR3, is provided. Nucleic acid molecules encoding DcR3, chimeric molecules and antibodies to DcR3 are also provided.
    Type: Grant
    Filed: June 28, 2001
    Date of Patent: July 20, 2004
    Assignee: Genentech, Inc.
    Inventors: Avi J. Ashkenazi, David Botstein, Kelly H. Dodge, Audrey Goddard, Austin L. Gurney, Kyung Jin Kim, David A. Lawrence, Robert Pitti, Margaret A. Roy, Daniel B. Tumas, William I. Wood
  • DcR3 polypeptide, a TNFR homolog
    Publication number: 20040014176
    Abstract: A TNFR homolog, identified as DcR3, is provided. Nucleic acid molecules encoding DcR3, chimeric molecules and antibodies to DcR3 are also provided.
    Type: Application
    Filed: June 6, 2003
    Publication date: January 22, 2004
    Applicant: Genentech, Inc.
    Inventors: Avi J. Ashkenzai, David Botstein, Kelly H. Dodge, Audrey Goddard, Austin L. Gurney, Kyung Jin Kim, David A. Lawrence, Robert Pitti, Margaret A. Roy, Daniel B. Tumas, William I. Wood
  • DcR3 polypeptide, a TNFR homolog
    Publication number: 20020065210
    Abstract: A TNFR homolog, identified as DcR3, is provided. Nucleic acid molecules encoding DcR3, chimeric molecules and antibodies to DcR3 are also provided.
    Type: Application
    Filed: June 28, 2001
    Publication date: May 30, 2002
    Applicant: Genentech, Inc.
    Inventors: Avi J. Ashkenazi, David Botstein, Kelly H. Dodge, Audrey Goddard, Austin L. Gurney, Kyung Jin Kim, David A. Lawrence, Robert Pitti, Margaret A. Roy, Daniel B. Tumas, William I. Wood
  • DcR3 polypeptide, a TNFR homolog
    Publication number: 20020061559
    Abstract: A TNFR homolog, identified as DcR3, is provided. Nucleic acid molecules encoding DcR3, chimeric molecules and antibodies to DcR3 are also provided.
    Type: Application
    Filed: June 28, 2001
    Publication date: May 23, 2002
    Applicant: Genentech, Inc.
    Inventors: Avi J. Ashkenazi, David Botstein, Kelly H. Dodge, Audrey Goddard, Austin L. Gurney, Kyung Jin Kim, David A. Lawrence, Robert Pitti, Margaret A. Roy, Daniel B. Tumas, William I. Wood