Patents by Inventor Robert PLACE
Robert PLACE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250147011Abstract: Disclosed is a covalently-linked multilayered three-dimensional matrix comprising capture molecules, linkers and spacers (referred to as a Molecular Net) for specific and sensitive analyte capture from a sample. Also disclosed herein is a Molecular Net comprising covalently-linked multilayered three-dimensional matrix comprising more than one type of capture molecule and more than one type of linker and may comprise one or more spacer for specific and sensitive capture of more than one type of analyte from a sample. A Molecular Net may comprise a pseudorandom nature. Use of various capture molecules, linkers and spacers in a Molecular Net may confer unique binding properties to a Molecular Net. Porosity, binding affinity, size exclusion abilities, filtration abilities, concentration abilities and signal amplification abilities of a Molecular Net may be varied and depend on the nature of components used in its fabrication.Type: ApplicationFiled: January 12, 2024Publication date: May 8, 2025Applicant: Sienna Cancer Diagnostics Inc.Inventors: Emily A STEIN, Bruce PHELPS, Robert PLACE, Dina UZRI
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Publication number: 20250101421Abstract: Provided is an oligonucleotide modulator for preventing or treating dystrophin-deficient-related disorders (DDD) including Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD). The oligonucleotide modulator comprises a sense nucleic acid strand and an antisense nucleic acid strand, wherein the sense nucleic acid strand and the antisense nucleic acid strand are independently an oligonucleotide strand of 16 to 35 nucleotides in length, in which one nucleotide strand has at least 75% base homology or complementarity to a target selected from a promoter region of a target gene UTRN.Type: ApplicationFiled: January 13, 2023Publication date: March 27, 2025Inventors: Moorim KANG, Robert PLACE, Longcheng LI
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Patent number: 12104157Abstract: Disclosed herein are engineered oligonucleotides for selective inhibition of polypeptide expression and activity. Also disclosed herein are methods of selectively inhibiting polypeptide expression and activity contacting an engineered oligonucleotide with a polynucleotide encoding the polypeptide.Type: GrantFiled: January 17, 2023Date of Patent: October 1, 2024Assignee: miRecule, Inc.Inventors: Robert Place, Anthony Saleh, Tishan Williams
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Publication number: 20240271134Abstract: Disclosed herein are engineered DUX4-targeting oligonucleotides for selective inhibition of RNA transcripts associated with a neuromuscular disease such as facioscapulohumeral muscular dystrophy. Also disclosed are vectors containing any of these, pharmaceutical formulations containing any of the these, and kits containing any of the these. Also disclosed herein are methods of selectively inhibiting polypeptide expression and activity by contacting a DUX4-targeting oligonucleotide with an RNA transcript associated with a neuromuscular disease such as facioscapulohumeral muscular dystrophy.Type: ApplicationFiled: January 12, 2024Publication date: August 15, 2024Inventors: Anthony SALEH, Grant BELGARD, Marton MUNZ, Charles MARUSAK, Robert PLACE
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Publication number: 20240141346Abstract: Disclosed herein are engineered oligonucleotides for selective inhibition of polypeptide expression and activity. Also disclosed herein are methods of selectively inhibiting polypeptide expression and activity contacting an engineered oligonucleotide with a polynucleotide encoding the polypeptide.Type: ApplicationFiled: August 25, 2023Publication date: May 2, 2024Inventors: Robert PLACE, Anthony SALEH, Tishan WILLIAMS
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Patent number: 11795459Abstract: Disclosed herein are engineered oligonucleotides for selective inhibition of polypeptide expression and activity. Also disclosed herein are methods of selectively inhibiting polypeptide expression and activity contacting an engineered oligonucleotide with a polynucleotide encoding the polypeptide.Type: GrantFiled: March 11, 2022Date of Patent: October 24, 2023Assignee: MIRECULE, INC.Inventors: Robert Place, Anthony Saleh, Tishan Williams
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Publication number: 20230295626Abstract: Disclosed herein are engineered oligonucleotides for selective inhibition of polypeptide expression and activity. Also disclosed herein are methods of selectively inhibiting polypeptide expression and activity contacting an engineered oligonucleotide with a polynucleotide encoding the polypeptide.Type: ApplicationFiled: January 17, 2023Publication date: September 21, 2023Inventors: Robert PLACE, Anthony SALEH, Tishan WILLIAMS
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Publication number: 20230132602Abstract: Disclosed herein are engineered oligonucleotides for selective inhibition of polypeptide expression and activity. Also disclosed herein are methods of selectively inhibiting polypeptide expression and activity contacting an engineered oligonucleotide with a polynucleotide encoding the polypeptide.Type: ApplicationFiled: April 2, 2021Publication date: May 4, 2023Inventors: Robert PLACE, Anthony SALEH, Tishan WILLIAMS
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Patent number: 11597930Abstract: Disclosed herein are engineered oligonucleotides for selective inhibition of polypeptide expression and activity. Also disclosed herein are methods of selectively inhibiting polypeptide expression and activity contacting an engineered oligonucleotide with a polynucleotide encoding the polypeptide.Type: GrantFiled: March 11, 2022Date of Patent: March 7, 2023Assignee: MIRECULE, INC.Inventors: Robert Place, Anthony Saleh, Tishan Williams
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Publication number: 20220213480Abstract: Disclosed herein are engineered oligonucleotides for selective inhibition of polypeptide expression and activity. Also disclosed herein are methods of selectively inhibiting polypeptide expression and activity contacting an engineered oligonucleotide with a polynucleotide encoding the polypeptide.Type: ApplicationFiled: March 11, 2022Publication date: July 7, 2022Inventors: Robert PLACE, Anthony SALEH, Tishan WILLIAMS
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Publication number: 20220213481Abstract: Disclosed herein are engineered oligonucleotides for selective inhibition of polypeptide expression and activity. Also disclosed herein are methods of selectively inhibiting polypeptide expression and activity contacting an engineered oligonucleotide with a polynucleotide encoding the polypeptide.Type: ApplicationFiled: March 11, 2022Publication date: July 7, 2022Inventors: Robert PLACE, Anthony SALEH, Tishan WILLIAMS
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Publication number: 20210318298Abstract: Disclosed is a covalently-linked multilayered three-dimensional matrix comprising capture molecules, linkers and spacers (referred to as a Molecular Net) for specific and sensitive analyte capture from a sample. Also disclosed herein is a Molecular Net comprising covalently-linked multilayered three-dimensional matrix comprising more than one type of capture molecule and more than one type of linker and may comprise one or more spacer for specific and sensitive capture of more than one type of analyte from a sample. A Molecular Net may comprise a pseudorandom nature. Use of various capture molecules, linkers and spacers in a Molecular Net may confer unique binding properties to a Molecular Net. Porosity, binding affinity, size exclusion abilities, filtration abilities, concentration abilities and signal amplification abilities of a Molecular Net may be varied and depend on the nature of components used in its fabrication.Type: ApplicationFiled: December 21, 2020Publication date: October 14, 2021Applicant: Sienna Cancer Diagnostics Inc.Inventors: Emily A. STEIN, Bruce PHELPS, Robert PLACE, Dina UZRI
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Patent number: 10900962Abstract: Disclosed is a covalently-linked multilayered three-dimensional matrix comprising capture molecules, linkers and spacers (referred to as a Molecular Net) for specific and sensitive analyte capture from a sample. Also disclosed herein is a Molecular Net comprising covalently-linked multilayered three-dimensional matrix comprising more than one type of capture molecule and more than one type of linker and may comprise one or more spacer for specific and sensitive capture of more than one type of analyte from a sample. A Molecular Net may comprise a pseudorandom nature. Use of various capture molecules, linkers and spacers in a Molecular Net may confer unique binding properties to a Molecular Net. Porosity, binding affinity, size exclusion abilities, filtration abilities, concentration abilities and signal amplification abilities of a Molecular Net may be varied and depend on the nature of components used in its fabrication.Type: GrantFiled: July 6, 2017Date of Patent: January 26, 2021Assignee: Sienna Cancer Diagnostics Inc.Inventors: Emily A. Stein, Bruce Phelps, Robert Place, Dina Uzri
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Publication number: 20180143188Abstract: Disclosed is a covalently-linked multilayered three-dimensional matrix comprising capture molecules, linkers and spacers (referred to as a Molecular Net) for specific and sensitive analyte capture from a sample. Also disclosed herein is a Molecular Net comprising covalently-linked multilayered three-dimensional matrix comprising more than one type of capture molecule and more than one type of linker and may comprise one or more spacer for specific and sensitive capture of more than one type of analyte from a sample. A Molecular Net may comprise a pseudorandom nature. Use of various capture molecules, linkers and spacers in a Molecular Net may confer unique binding properties to a Molecular Net. Porosity, binding affinity, size exclusion abilities, filtration abilities, concentration abilities and signal amplification abilities of a Molecular Net may be varied and depend on the nature of components used in its fabrication.Type: ApplicationFiled: July 6, 2017Publication date: May 24, 2018Applicant: Sevident, Inc.Inventors: Emily A. STEIN, Bruce PHELPS, Robert PLACE, Dina UZRI
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Patent number: 9733242Abstract: Disclosed is a covalently-linked multilayered three-dimensional matrix comprising capture molecules, linkers and spacers (referred to as a Molecular Net) for specific and sensitive analyte capture from a sample. Also disclosed herein is a Molecular Net comprising covalently-linked multilayered three-dimensional matrix comprising more than one type of capture molecule and more than one type of linker and may comprise one or more spacer for specific and sensitive capture of more than one type of analyte from a sample. A Molecular Net may comprise a pseudorandom nature. Use of various capture molecules, linkers and spacers in a Molecular Net may confer unique binding properties to a Molecular Net. Porosity, binding affinity, size exclusion abilities, filtration abilities, concentration abilities and signal amplification abilities of a Molecular Net may be varied and depend on the nature of components used in its fabrication.Type: GrantFiled: March 14, 2014Date of Patent: August 15, 2017Assignee: Sevident, Inc.Inventors: Emily Stein, Bruce Phelps, Robert Place, Dina Uzri
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Publication number: 20140315759Abstract: Disclosed is a covalently-linked multilayered three-dimensional matrix comprising capture molecules, linkers and spacers (referred to as a Molecular Net) for specific and sensitive analyte capture from a sample. Also disclosed herein is a Molecular Net comprising covalently-linked multilayered three-dimensional matrix comprising more than one type of capture molecule and more than one type of linker and may comprise one or more spacer for specific and sensitive capture of more than one type of analyte from a sample. A Molecular Net may comprise a pseudorandom nature. Use of various capture molecules, linkers and spacers in a Molecular Net may confer unique binding properties to a Molecular Net. Porosity, binding affinity, size exclusion abilities, filtration abilities, concentration abilities and signal amplification abilities of a Molecular Net may be varied and depend on the nature of components used in its fabrication.Type: ApplicationFiled: March 14, 2014Publication date: October 23, 2014Applicant: Sevident, Inc.Inventors: Emily STEIN, Bruce PHELPS, Robert PLACE, Dina UZRI