Patents by Inventor Robert Plenge

Robert Plenge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMBINATION THERAPIES COMPRISING APREMILAST AND TYK2 INHIBITORS
    Publication number: 20250235450
    Abstract: Provided herein are methods of treating diseases and disorder responsive to the inhibition of PDE4 comprising administering apremilast and a Tyk2 inhibitor to a subject. Also provided herein are pharmaceutical compositions comprising apremilast and a Tyk2 inhibitor.
    Type: Application
    Filed: September 3, 2024
    Publication date: July 24, 2025
    Inventors: Peter Henry Schafer, Robert Plenge, Mary Adams, Lisa Beebe, Gilles Buchwalter, Tiffany Carr, Te-chen Tzeng
  • PROTEINASE 3 (PR3) CHIMERIC AUTOANTIBODY RECEPTOR T CELLS AND RELATED METHODS AND USES
    Publication number: 20250161359
    Abstract: Provided herein are cell and protein therapeutics that comprise a Proteinase 3 (PR3) antibody binding domain, such as a wild type PR3 protein or mutant PR3 protein, and methods of use thereof. Also provided herein arc chimeric autoantibody receptors (CAARs) comprising an extracellular PR3 antibody binding domain. Among the provided CAARs are those in which the extracellular PR3 antibody binding domain ia a wild type or mutated PR3 protein or fragment thereof that are able to be specifically bound by an anti-PR3 antineutrophil cytoplasmic antibody (ANCA). Also provided herein are polynucleotides that encode the provided CAARs, genetically engineered cells such as T cells containing the provided CAARs, and to related methods and uses thereof in adoptive cell therapy.
    Type: Application
    Filed: February 21, 2023
    Publication date: May 22, 2025
    Applicant: Juno Therapeutics, Inc.
    Inventors: Kofi Agyare MENSAH, Dennis Michael ZALLER, Steven Anthony SAENZ, Xi JIN, William Andrew JOHNSEN, Ginger Chao RAKESTRAW, Joseph Rene PAQUETTE, Robert PLENGE, Stephen Jacob GOLDFLESS, Jeffrey Lee DANTZLER, Collin William HAUSKINS, Cyr Clovis Chua DE IMUS, Sanjib DUTTA, Kristoff Theodor HOMAN
  • ANTI-BCMA THERAPY IN AUTOIMMUNE DISORDERS
    Publication number: 20240052064
    Abstract: The present invention relates to the treatment or management of autoimmune disorders, such as autoimmune disorders caused by autoreactive B lineage cells, e.g. anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).
    Type: Application
    Filed: February 11, 2021
    Publication date: February 15, 2024
    Inventors: Kofi MENSAH, Robert PLENGE, Sophie ROY, Dennis ZALLER, Jennifer DOVEY, Steven SAENZ, Jill HENAULT, Camille DOYKAN, Jenna CALVINO, Xi JIN, Joseph PAQUETTE
  • COMBINATION THERAPIES COMPRISING APREMILAST AND TYK2 INHIBITORS
    Publication number: 20220339151
    Abstract: Provided herein are methods of treating diseases and disorder responsive to the inhibition of PDE4 comprising administering apremilast and a Tyk2 inhibitor to a subject. Also provided herein are pharmaceutical compositions comprising apremilast and a Tyk2 inhibitor.
    Type: Application
    Filed: May 9, 2022
    Publication date: October 27, 2022
    Inventors: Peter Henry Schafer, Robert Plenge, Mary Adams, Lisa Beebe, Gilles Buchwalter, Tiffany Carr, Te-chen Tzeng
  • Combination therapies comprising apremilast and Tyk2 inhibitors
    Patent number: 11357775
    Abstract: Provided herein are methods of treating diseases and disorder responsive to the inhibition of PDE4 comprising administering apremilast and a Tyk2 inhibitor to a subject. Also provided herein are pharmaceutical compositions comprising apremilast and a Tyk2 inhibitor.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: June 14, 2022
    Assignee: Celgene Corporation
    Inventors: Peter Henry Schafer, Robert Plenge, Mary Adams, Lisa Beebe, Gilles Buchwalter, Tiffany Carr, Te-chen Tzeng
  • COMBINATION THERAPIES COMPRISING APREMILAST AND TYK2 INHIBITORS
    Publication number: 20200345731
    Abstract: Provided herein are methods of treating diseases and disorder responsive to the inhibition of PDE4 comprising administering apremilast and a Tyk2 inhibitor to a subject. Also provided herein are pharmaceutical compositions comprising apremilast and a Tyk2 inhibitor.
    Type: Application
    Filed: April 30, 2019
    Publication date: November 5, 2020
    Inventors: Peter Henry Schafer, Robert Plenge, Mary Adams, Lisa Beebe, Gilles Buchwalter, Tiffany Carr, Te-chen Tzeng