Abstract: A system for displaying a simulated room can comprise a projector, a wall structure element, a physical object, and a room customization station. The room customization station can view images of selectable products and allows a selection thereof to be displayed on the wall structure element or the physical object. The projector can display the selectable product(s) on the wall structure element or the physical object. The physical object can be adjustable in size for different selectable product sizes. The system can include a physical accessory placeable in the simulated room to facilitate visualization of how the physical accessory would appear in the simulated room with the selectable product. Further, the room customization station can prevent a portion of the images from being projected onto a physical feature in the simulated room and allow other portions of the images to be projected into a portion of the simulated room.

Abstract: Described herein are methods of treating a proliferative disorder (e.g., cancer) in a patient by administering a DNA damaging agent and between about 12 and about 48 hours later administering to the subject a compound that inhibits ATR protein kinase. Methods of treating a proliferative disorder (e.g., cancer) in a patient by administering a compound that inhibits ATR protein kinase are also described. Exemplary ATR inhibitors are represented by Formulae A-I and A-II: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined herein.

Abstract: An analyzing system is provided. The analyzing system includes a fluid container defining a sample chamber where a sample is contained in the sample chamber, and a sensor including a transparent body with a reverse face and an obverse face where the obverse face having a nanostructured surface. The nanostructured surface includes a plurality of elongate nanostructures having a respective longitudinal axis that is disposed substantially perpendicularly to the obverse face. The analyzing system includes an excitation and detection apparatus that includes an excitation source for generating a beam of polarized radiation and a corresponding radiation detector where the sensor is coupled to the fluid container such that the nanostructured surface is exposed to the sample chamber, to the sample located therein.

Abstract: Described herein are methods of treating a proliferative disorder (e.g., cancer) in a patient by administering a DNA damaging agent and between about 12 and about 48 hours later administering to the subject a compound that inhibits ATR protein kinase. Methods of treating a proliferative disorder (e.g., cancer) in a patient by administering a compound that inhibits ATR protein kinase are also described. Exemplary ATR inhibitors are represented by Formulae A-I and A-II or a pharmaceutically acceptable salt thereof, wherein the variables are as defined herein.

Abstract: An analyzing system comprises a multi-well sample carrier in which each well has a transparent bottom with a nanostructured surface inside the well. The sample carrier can be installed in a reader device so that each well of the sample carrier is aligned with a respective light guiding unit of the reader device. In use, each light guiding unit directs a beam of excitation light to the bottom of the respective well, and directs a beam of reflected light from the bottom of the respective well. The nanostructured surface acts as a plasmonic sensor to facilitate analysis of the contents of the wells. The system allows highly sensitive quantification and characterisation of biological interactions in real time across multiple wells, and with improvements in yields, quality and production times.

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase and combination therapies thereof. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: wherein the variables are as defined herein.

Abstract: A system for displaying a simulated room can comprise a projector, a wall structure element, a physical object, and a room customization station. The room customization station can view images of selectable products and allows a selection thereof to be displayed on the wall structure element or the physical object. The projector can display the selectable product(s) on the wall structure element or the physical object. The physical object can be adjustable in size for different selectable product sizes. The system can include a physical accessory placeable in the simulated room to facilitate visualization of how the physical accessory would appear in the simulated room with the selectable product. Further, the room customization station can prevent a portion of the images from being projected onto a physical feature in the simulated room and allow other portions of the images to be projected into a portion of the simulated room.

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase and combination therapies thereof. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: wherein the variables are as defined herein.

Abstract: A system for displaying a simulated room can comprise at least one projector, at least one wall structure element, at least one physical object, and a room customization station. The room customization station can be configured to permit viewing images of selectable products and selecting at least one of the selectable products to be displayed on at least one of the at least one wall structure element or the at least one physical object. The projector(s) can be adapted to display the selectable product(s) on at least one of the at least one wall structure element or the physical object(s). The physical object can be adjustable in size to correspond to different sizes of selectable products. The system can further include at least one physical accessory adapted to be placed in the simulated room to facilitate visualization of how the at least one physical accessory would appear in the presence of the simulated room and the at least one selectable product.

Abstract: The present disclosure relates to methods of identifying a cancer having sensitivity to an ATR inhibitor compound, and treating subjects with such identified cancers with the ATR inhibitor, particularly in combination with a DNA damaging agent.

Abstract: The application relates to markers for seizures and epilepsy. Polypeptide expression panels or arrays are provided, comprising one or more probes capable of binding specific polypeptides in blood plasma or blood serum of a mammalian subject. Also provided are methods for detecting seizure, methods for predicting seizure, use of sICAM-5 in the treatment of seizure, methods for assessing the effectiveness of a treatment of seizure, and diagnostic kits.

Abstract: This invention relates to methods and compositions for treating pancreatic cancer. More specifically, this invention relates to treating pancreatic cancer with certain ATR inhibitors in combination with gemcitabine and/or radiation therapy. This invention also relates to methods and compositions for treating non-small cell lung cancer. More specifically, this invention relates to treating non-small cell lung cancer with an ATR inhibitor in combination with cisplatin or carboplatin, etoposide, and ionizing radiation.

Abstract: This invention relates to methods and compositions for treating pancreatic cancer. More specifically, this invention relates to treating pancreatic cancer with certain ATR inhibitors in combination with gemcitabine and/or radiation therapy. This invention also relates to methods and compositions for treating non-small cell lung cancer. More specifically, this invention relates to treating non-small cell lung cancer with an ATR inhibitor in combination with cisplatin or carboplatin, etoposide, and ionizing radiation.

Abstract: An analysing apparatus comprises a fluid container defining a sample chamber. A sensor having a transparent body with a nanostructured surface is coupled to the fluid container such that the nanostructured surface is exposed to the sample chamber. An excitation and detection apparatus directs a beam of incident polarised electromagnetic radiation onto the reverse face of the body at the Brewster angle, causing no or substantially no reflection of the polarised radiation from the reverse face. The beam of reflected radiation emerges from the reverse face after reflection from the nanostructured surface. The apparatus is simpler and cheaper in comparison with known alternatives that use ATR prisms to create ATR of the light to excite a planar surface.

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase and combination therapies thereof The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: wherein the variables are as defined herein.

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase and combination therapies thereof. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: wherein the variables are as defined herein.

Abstract: An analyzing system is provided. The analyzing system includes a fluid container defining a sample chamber where a sample is contained in the sample chamber, and a sensor including a transparent body with a reverse face and an obverse face where the obverse face having a nanostructured surface. The nanostructured surface includes a plurality of elongate nanostructures having a respective longitudinal axis that is disposed substantially perpendicularly to the obverse face. The analyzing system includes an excitation and detection apparatus that includes an excitation source for generating a beam of polarized radiation and a corresponding radiation detector where the sensor is coupled to the fluid container such that the nanostructured surface is exposed to the sample chamber, to the sample located therein.

Abstract: An analysing apparatus comprises a fluid container defining a sample chamber. A sensor having a transparent body with a nanostructured surface is coupled to the fluid container such that the nanostructured surface is exposed to the sample chamber. An excitation and detection apparatus directs a beam of incident polarised electromagnetic radiation onto the reverse face of the body at the Brewster angle, causing no or substantially no reflection of the polarised radiation from the reverse face. The beam of reflected radiation emerges from the reverse face after reflection from the nanostructured surface. The apparatus is simpler and cheaper in comparison with known alternatives that use ATR prisms to create ATR of the light to excite a planar surface.