Abstract: The present disclosure provides vector stuffer polynucleotides and compositions thereof, including expression constructs and vectors, such as viral vectors and methods of delivering a therapeutic agent (e.g., inhibitory nucleic acid) to a mammal or treating a disease.

Abstract: A turbine engine having a compressor section, a combustor section, a turbine section, and a rotatable drive shaft that couples a portion of the turbine section and a portion of the compressor section. A bypass conduit couples the compressor section to the turbine section while bypassing at least the combustion section. At least one particle separator is located in the turbine engine having a separator inlet that receives a bypass stream, a separator outlet that receives a reduced-particle stream flows, and a particle outlet that receives a concentrated-particle stream comprising separated particles. A conduit, fluidly coupled to the particle outlet, extends through an interior of at least one stationary vane.

Abstract: A vehicle is provided including a structure including a skin defining an outside surface exposed to ambient cooling flow and an inside surface. The structure includes a first structural member extending from the inside surface of the skin and a second structural member extending from the inside surface of the skin; and a thermal management system including a heat exchanger assembly positioned adjacent to, and in thermal communication with, the inside surface of the skin, the heat exchanger assembly positioned at least partially between the first and second structural members of the structure.

Abstract: A system for controlling blade clearances within a gas turbine engine includes a rotor disk and a rotor blade coupled to the rotor disk. Additionally, the system includes an outer turbine component positioned outward of the rotor blade such that a clearance is defined between the rotor blade and the outer turbine component. Furthermore, the system includes a heat exchanger configured to receive a flow of cooling air bled from the gas turbine engine and transfer heat from the received flow of the cooling air to a flow of coolant to generate cooled cooling air. Moreover, the system includes a valve configured to control the flow of the coolant to the heat exchanger. In this respect, the cooled cooling air is supplied to at least one of the rotor disk or the rotor blade to adjust the clearance between the rotor blade and the outer turbine component.

Abstract: A turbine engine having a compressor section, a combustor section, a turbine section, and a rotatable drive shaft that couples a portion of the turbine section and a portion of the compressor section. A bypass conduit couples the compressor section to the turbine section while bypassing at least the combustion section. At least one particle separator is located in the turbine engine having a separator inlet that receives a bypass stream, a separator outlet that receives a reduced-particle stream flows, and a particle outlet that receives a concentrated-particle stream comprising separated particles. A conduit, fluidly coupled to the particle outlet, extends through an interior of at least one stationary vane.

Abstract: A patient temperature control system for automated temperature control according to a programmed protocol. In one aspect, at least one programmed protocol may be established for each of a plurality of patient thermal therapy phases. In turn, the temperature of a thermal exchange medium may be controlled upon the programmed protocol during each of the phases. A plurality of programmed protocols may be established, wherein a selected protocol may be utilized for automated temperature control during patient thermal therapy. The protocol may include a target patient temperature and/or a set duration for one or more of the phase of thermal therapy. The protocol may be user-definable and modifiable during therapy. In a multiphase configuration, automatic termination and initiation of successive phases may be selectively established by a user, based on target patient temperature data and/or set duration data on a phase-specific basis.

Abstract: A vehicle is provided including a structure including a skin defining an outside surface exposed to ambient cooling flow and an inside surface. The structure includes a first structural member extending from the inside surface of the skin and a second structural member extending from the inside surface of the skin; and a thermal management system including a heat exchanger assembly positioned adjacent to, and in thermal communication with, the inside surface of the skin, the heat exchanger assembly positioned at least partially between the first and second structural members of the structure.

Abstract: A turbine engine having an inducer assembly. The inducer assembly includes a centrifugal separator fluidly coupled to an inducer with an inducer inlet and an inducer outlet. The centrifugal separator includes a body, an angular velocity increaser to form a concentrated-particle stream and a reduced-particle stream, a flow splitter, and an exit conduit fluidly coupled to the body to receive the reduced-particle stream and define a separator outlet.

Abstract: An annular fluid flow control or metering device comprises: first and second annular plates disposed in an annular flow path, the first annular plate and second annular plates being made of different first and second materials, the first annular plate having a lower first coefficient of thermal expansion than a second coefficient of thermal expansion of the second annular plate, the first annular plate abutting or in contact with the second annular plate, the first annular plate including at least one first metering aperture, and the second annular plate being more thermally responsive than the first annular plate wherein the second annular plate being configured to radially grow and shrink to at least partly obstruct the at least one first metering aperture for metering or controlling a flow of fluid through the at least one first metering aperture.

Abstract: A system for controlling blade clearances within a gas turbine engine includes a rotor disk and a rotor blade coupled to the rotor disk. Additionally, the system includes an outer turbine component positioned outward of the rotor blade such that a clearance is defined between the rotor blade and the outer turbine component. Furthermore, the system includes a heat exchanger configured to receive a flow of cooling air bled from the gas turbine engine and transfer heat from the received flow of the cooling air to a flow of coolant to generate cooled cooling air. Moreover, the system includes a valve configured to control the flow of the coolant to the heat exchanger. In this respect, the cooled cooling air is supplied to at least one of the rotor disk or the rotor blade to adjust the clearance between the rotor blade and the outer turbine component.

Abstract: An apparatus and method of cooling a hot portion of a gas turbine engine, such as a multi-stage compressor of a gas turbine engine, by reducing an operating air temperature in a space between a seal and a blade post of adjacent stages by routing cooling air through an inlet in the vane, passing the routed cooling air through the vane, and emitting the routed cooling air into the space.

Abstract: A seal assembly to seal a gas turbine hot gas path flow at an interface of a combustor liner and a downstream component, such as a stage one turbine nozzle, in a gas turbine. The seal assembly including a piston ring seal housing, defining a cavity, and a piston ring disposed within the cavity. The piston ring disposed circumferentially about the combustor liner. The piston ring is responsive to a regulated pressure to secure sealing engagement of the piston ring and outer surface of the combustor liner. The seal assembly includes at least one of one or more sectional through-slots, bumps or channel features to provide for a flow therethrough of a high-pressure (Phigh) bypass airflow exiting a compressor to the cavity. The high-pressure (Phigh) bypass airflow exerting a radial force on the piston ring.

Abstract: An apparatus for a turbine engine comprising an outer casing, an engine core provided within outer casing and having a at least one set of blades, and through which gasses flow in a forward to aft direction, an outer drum located within the outer casing to define an annular cavity. A set of seals extending between the first surface and the second surface to define at least one cooled cavity within the annular cavity.

Abstract: A seal assembly to seal a gas turbine hot gas path flow at an interface of a combustor liner and a downstream component, such as a stage one turbine nozzle, in a gas turbine. The seal assembly including a piston ring seal housing, defining a cavity, and a piston ring disposed within the cavity. The piston ring disposed circumferentially about the combustor liner. The piston ring is responsive to a regulated pressure to secure sealing engagement of the piston ring and outer surface of the combustor liner. The seal assembly includes at least one of one or more sectional through-slots, bumps or channel features to provide for a flow therethrough of a high-pressure (Phigh) bypass airflow exiting a compressor to the cavity. The high-pressure (Phigh) bypass airflow exerting a radial force on the piston ring.

Abstract: An assembly for a turbine engine comprising a plurality of circumferentially arranged segments having first and second confronting end faces. The first and second confronting end faces include a multi-channel spline seal assembly. The multi-channel spline seal assembly includes at least a first and second channel wherein confronting first or second channels can receive at least one spline seal.

Abstract: A turbine engine having an inducer assembly. The inducer assembly includes a centrifugal separator fluidly coupled to an inducer with an inducer inlet and an inducer outlet. The centrifugal separator includes a body, an angular velocity increaser to form a concentrated-particle stream and a reduced-particle stream, a flow splitter, and an exit conduit fluidly coupled to the body to receive the reduced-particle stream and define a separator outlet.

Abstract: An annular fluid flow control or metering device comprises: first and second annular plates disposed in an annular flow path, the first annular plate and second annular plates being made of different first and second materials, the first annular plate having a lower first coefficient of thermal expansion than a second coefficient of thermal expansion of the second annular plate, the first annular plate abutting or in contact with the second annular plate, the first annular plate including at least one first metering aperture, and the second annular plate being more thermally responsive than the first annular plate wherein the second annular plate being configured to radially grow and shrink to at least partly obstruct the at least one first metering aperture for metering or controlling a flow of fluid through the at least one first metering aperture.

Abstract: A turbine engine having a bypass fluid conduit coupled to the turbine section includes at least one particle separator located within the bypass fluid conduit to separate particles from a bypass fluid stream prior to the bypass stream reaching the turbine section for cooling. A centrifugal separator for removing particles from a fluid stream includes an angular velocity increaser, a particle outlet, an angular velocity decreaser downstream of the angular velocity increaser, and a bend provided between the angular velocity increaser and the angular velocity decreaser.

Abstract: An airfoil assembly and method for an engine comprising a plurality of circumferentially arranged platforms having confronting end faces each platform defining a base portion from which an airfoil extends outwardly defining a radial direction and from which a set of legs extends radially inward, a disk post coupled to at least one leg of the set of legs, a cavity formed by the platform, set of legs, and the disk post defining a static pressure zone during operation, a high pressure zone located exteriorly of the cavity; and at least one blocking spline seal.

Abstract: A centrifugal separator for removing particles from a fluid stream includes an angular velocity increaser configured to increase the angular velocity of a fluid stream, a flow splitter configured to split the fluid stream to form a concentrated-particle stream and a reduced-particle stream, and an exit conduit configured to receive the reduced-particle stream. An inducer assembly for a turbine engine includes an inducer with a flow passage having an inducer inlet and an inducer outlet in fluid communication with a turbine section of the engine, and a particle separator, which includes a particle concentrator that receives a compressed stream from a compressor section of the engine and a flow splitter. A turbine engine includes a cooling air flow circuit which supplies a fluid stream to a turbine section of the engine for cooling, a particle separator located within the cooling air flow circuit, and an inducer forming a portion of the cooling air flow circuit in fluid communication with the particle separator.