Abstract: The present invention provides substantially pure integrins containing a novel &bgr; subunit designated as &bgr;6. The novel &bgr;6 subunit forms heterodimers with &agr;V and &agr;F. Methods of controlling cell adhesion using the &bgr;6-containing integrins are also provided.

Abstract: The invention provides methods for producing a plurality of monoclonal antibodies, which plurality contains an antibody for each member of a plurality of different antigens. In general, the methods involve administering a plurality of antigens or a cellular immunogen made up of a cell population expressing a plurality of antigens to a single animal to induce an immune response against the plurality of antigens, and producing monoclonal antibodies from antibody-producing cells of the animal. In general, the antigens expressed by the cells of the cellular immunogen are not native to the cells, and the cells are derived from the same species as the host. The invention further provides screening methods for identifying monoclonal antibodies of interest, and kits for carrying out the subject methods. The subjects systems, methods and kits find use in a variety of different industrial, medical and research applications.

Abstract: The invention provides methods for producing a modified nucleic acid that encodes a modified a rabbit antibody so that the modified rabbit antibody is less immunogenic in a non-rabbit host than an unmodified parent rabbit antibody. The invention further provides modified nucleic acids made by these methods, as well as vectors and host cells comprising the nucleic acids, and methods for producing the encoded modified antibodies. Also provided are modified rabbit antibodies encoded by subject nucleic acids, and compositions containing the same. The invention further provides kits for carrying out the subject methods.

Abstract: The invention provides methods for producing a monoclonal antibody in a host cell. The methods involve introducing linear expression cassettes containing coding sequences for immunoglobulin heavy and light chains into a host cell and expressing a monoclonal antibody. In most embodiments, the immunoglobulin heavy and light chains are both derived from a single antibody-producing cell. The invention further provides methods for producing a plurality of monoclonal antibodies, and methods of screening a plurality of monoclonal antibodies to identify a monoclonal antibody of interest and its encoding nucleic acid. Also provided by the invention are host cells containing monoclonal antibody-encoding sequences, and libraries of monoclonal antibodies for use in screening methods. The invention further provides kits for carrying out the subject methods. The subjects systems, methods and kits find use in a variety of different industrial, medical and research applications.

Abstract: The present invention provides anti-&bgr;6-antibodies that block attachment of &agr;v&bgr;6 to its ligands such as fibronection and tenascin.

Abstract: The present invention provides substantially pure integrins containing a novel &bgr; subunit designated as &bgr;6. The novel &bgr;6 subunit forms heterodimers with &agr;V and &agr;F. Methods of controlling cell adhesion using the &bgr;6-containing integrins are also provided.

Abstract: The present invention provides substantially pure integrins containing a novel &bgr; subunit designated as &bgr;6. The novel &bgr;6 subunit forms heterodimers with &agr;V and &agr;F. Methods of controlling cell adhesion using the &bgr;6-containing integrins are also provided.

Abstract: The present invention provides substantially pure integrins containing a novel &bgr; subunit designated as &bgr;6. The novel &bgr;6 subunit forms heterodimers with &agr;V and &agr;F. Methods of controlling cell adhesion using the &bgr;6-containing integrins are also provided.

Abstract: The present invention provides substantially pure integrins containing a novel &bgr; subunit designated as &bgr;6. The novel &bgr;6 subunit forms heterodimers with &agr;V and &agr;F. Methods of controlling cell adhesion using the &bgr;6-containing integrins are also provided.

Abstract: Nucleic acids encoding an integrin &bgr;-subunit, designated &bgr;6, are provided along with nucleic acids encoding fragments specific to &bgr;6. Also disclosed are vectors containing a gene encoding &bgr;6 or fragments specific to &bgr;6, and hosts containing such vectors. Nucleic acids that specifically hybridize with the disclosed nucleic acids are also provided.

Abstract: Methods and compositions comprising antagonists of &agr;v&bgr;6 are provided for the treatment of acute lung injury fibrosis.

Abstract: The present invention provides substantially pure integrins containing a novel .beta. subunit designated as .beta..sub.6. The novel .beta..sub.6 subunit forms heterodimers with .alpha..sub.V and .alpha..sub.F. Methods of controlling cell adhesion using the B.sub.6 -containing integrins are also provided.