Patents by Inventor Robert R. Aksamit

Robert R. Aksamit has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human-mouse hybrid cell line expressing monocyte-macrophage properties
    Patent number: 4970162
    Abstract: Human leukocytes, which contain monocytes and neutrophils that exhibit chemotaxis to N-formylmethionine-leucine-phenylalanine (FMLP), were fused with the mouse macrophage RAW264-TG3 cell line which exhibits chemotaxis to endotoxin-activated mouse serum (EAMS) but not to FMLP. From such fusions twelve cell lines were isolated, all of which migrated to EAMS. Four of the cell lines also exhibited chemotaxis to FMLP, and of these cell lines only one, WBC264-9, retained the capacity to migrate to FMLP after culture for 20 or more passages. WBC264-9 exhibits chemotaxis to FMLP and provides a novel system to investigate attractant-specific biochemical reactions necessary for chemotaxis.
    Type: Grant
    Filed: November 13, 1985
    Date of Patent: November 13, 1990
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventor: Robert R. Aksamit