Abstract: There are provided herein, inter alia, cationic amphipathic polymers, complexes, and compositions comprising same, and methods for their use including for the delivery of therapeutic, diagnostic and imaging agents, including nucleic acids, into a cell. The complexes, compositions and methods may facilitate delivery and targeted release of the therapeutic, diagnostic and imaging agents to particular cell types and tissues.

Abstract: An improved gasketed mounting cup for an aerosol container wherein the mounting cup has a curvilinear channel portion and the gasket is a folded-over sleeve gasket, simulating the gasket thickness of a cut gasket; wherein the outer segment of the folded-over gasket is longer than the other gasket segment but of a limited length that will allow the ultimate positioning of the gasket without the longer gasket segment contacting the surface of the mounting cup and being wedged between the bead of the container and the mounting cup during advancement of the gasket into the mounting cup.

Abstract: An apparatus for forming a double-segment overlapping gasket material for the mounting cup of an aerosol container comprising a punch mounted on a reciprocating ram having a central opening for the body of the mounting cup and a nose portion adapted to extend within the channel portion of the mounting cup, said nose portion having a specific shape and the punch having a shoulder in the inside diameter of the punch to urge the gasket material disposed on the body portion of the cup into the channel portion, whereat upon the bottoming of the punch against the gasket, a fold line is formed in the gasket which results in the formation of the overlapping double-segment gasket.

Abstract: An improved gasketed mounting cup for an aerosol container wherein the mounting cup has a curvilinear channel portion and the gasket is a folded-over sleeve gasket, simulating the gasket thickness of a cut gasket; wherein the outer segment of the folded-over gasket is longer than the other gasket segment but of a limited length that will allow the ultimate positioning of the gasket without the longer gasket segment contacting the surface of the mounting cup and being wedged between the bead of the container and the mounting cup during advancement of the gasket into the mounting cup.

Abstract: An improved gasketed mounting cup for an aerosol container wherein the mounting cup has a curvilinear channel portion and the gasket is a folded-over sleeve gasket, simulating the gasket thickness of a cut gasket; wherein the outer segment of the folded-over gasket is longer than the other gasket segment but of a limited length that will allow the ultimate positioning of the gasket without the longer gasket segment contacting the surface of the mounting cup and being wedged between the bead of the container and the mounting cup during advancement of the gasket into the mounting cup.

Abstract: An improved gasketed mounting cup for an aerosol container wherein the mounting cup has a curvilinear channel portion and the gasket is a folded-over sleeve gasket, simulating the gasket thickness of a cut gasket; wherein the outer segment of the folded-over gasket is longer than the other gasket segment but of a limited length that will allow the ultimate positioning of the gasket without the longer gasket segment contacting the surface of the mounting cup and being wedged between the bead of the container and the mounting cup during advancement of the gasket into the mounting cup.

Abstract: A valve mounting assembly for an aerosol container comprising a mounting cup and a sleeve gasket initially positioned on at least a substantial portion of the skirt of the mounting cup. The sleeve gasket has an axial height and radial thickness of from about 0.080 to 0.150 inches and from about 0.030 to 0.060 inches, respectively; said dimension being preferably from about 0.090 to 0.140 inches and from about 0.035 to 0.055 inches, respectively and said dimensions most preferably being from about 0.100 to 0.130 inches and from about 0.040 to 0.050 inches. In a method herein, the gasket is advanced onto the skirt of the mounting cup, and then advanced into the annular channel of the mounting cup and deformed about 90° to form a gasket of dimensions equivalent to a cut gasket. The gasket may be cut from an extruded tube of gasket material, which can be cut to very precise longitudinal dimensions.

Abstract: A method for filling an aerosol container with propellant, wherein an enlarged button actuator (button having a diameter base of at least fifteen millimeters) having a discharge orifice communication with a socket for receiving the hollow valve stem of an aerosol valve, an annular wall radially outward of the socket for sealing on a pedestal of a valve mounting cup and a sealing surface on the outer wall for mating with a propellant filling head, and at least one conduit communicating a chamber defined, in part, by the annular wall sealing on the pedestal and a chamber defined by the interior of the filling head and the outer surface of the button is employed. The method provides a system for propellant filling of the container with the button on the stem of the associated valve coupled to the aerosol container opening.

Abstract: This invention concerns an aerosol valve stem configuration wherein the discharge end of the valve stem has a distortable membrane flange extending therefrom. The distortable membrane flange permits accommodation of filling lighters wherein the pin in the lighter opener is either of the centrally disposed orifice through the pin or of the orifice being disposed through the side wall of the pin.

Abstract: A container closure 10 for screw top containers such as beverage container, the closure 10 having a generally cylindrical tamper-evident band 11 joined by a plurality of frangible bridges 13b, 13c and at least one extended non-frangible bridge 13a to the free edge of a skirt 16 of the closure 10. The band 11 has a segmented internal rib 18 which engages an external retaining flange 30 of the container 29 when the closure is applied to the container. An L-shaped slot 17 extends through the side wall of the tamper-evident band 11, the horizontal leg 61 of which terminates directly adjacent to or under the extended non-frangible bridge 13a. A weakened frangible region 63 of the band extends from the terminating end 62 of the horizontal leg 61 axially downward to the bottom of the band 11. On removal of the closure 10 from the container 29, the frangible bridges 13b, 13cand frangible region 63 rupture and the band 11 remains captive at the extended bridge 13a to the skirt.