Abstract: Presently disclosed is a hydraulic pump device and its use thereof, especially in a fluid delivery system. In one embodiment, the fluid delivery system is an inexpensive, single-use device for slow dosing medicament applications. The fluid delivery system may employ a spring-compressed bellows crank or other combination of simple mechanisms operating according to the well-known peristaltic principle to force a volume of ultrapure bio-inert hydraulic fluid through an aperture, thereby expanding one chamber of a two chamber hydraulic cylinder. The second, fluid storage chamber, containing the medicament, is emptied through a conventional orifice in response to the expansion of the pump chamber. The medicament may thence flow through any suitable infusion set into a patient removeably attached thereto.

Abstract: Presently disclosed is a hydraulic pump device and its use thereof, especially in a fluid delivery system. In one embodiment, the fluid delivery system is an inexpensive, single-use device for slow dosing medicament applications. The fluid delivery system may employ a spring-compressed bellows crank or other combination of simple mechanisms operating according to the well-known peristaltic principle to force a volume of ultrapure bio-inert hydraulic fluid through an aperture, thereby expanding one chamber of a two chamber hydraulic cylinder. The second, fluid storage chamber, containing the medicament, is emptied through a conventional orifice in response to the expansion of the pump chamber. The medicament may thence flow through any suitable infusion set into a patient removeably attached thereto.

Abstract: Presently disclosed is a hydraulic pump device and use thereof, especially in a fluid delivery system. In one embodiment, the fluid delivery system is an inexpensive, single-use device for slow dosing medicament applications. The fluid delivery system may employ a spring-compressed bellows crank or other combination of simple mechanisms operating according to the well-known peristaltic principle to force a volume of ultrapure bio-inert hydraulic fluid through an aperture, thereby expanding one chamber of a two chamber hydraulic cylinder. The second, fluid storage chamber, containing the medicament, is emptied through a conventional orifice in response to the expansion of the pump chamber. The medicament may thence flow through any suitable infusion set into a patient removeably attached thereto.

Abstract: Microneedle devices for transport of molecules, including drugs and biological molecules, across tissue, are provided. The microneedle devices permit drug delivery or removal of body fluids at clinically relevant rates across skin or other tissue barriers, with minimal or no damage, pain, or irritation to the tissue. Microneedles can be formed of biodegradable or non-biodegradable polymeric materials or metals. In a preferred embodiment, a microneedle device includes a plugging element comprising a platform including a plurality of microneedle plugs for preventing skin or other tissue barriers from entering the hollow microneedles. In another preferred embodiment, a microneedle device includes a plurality of bioerodible elements for temporarily plugging the hollow microneedles, thereby preventing skin or other tissue barriers from entering the hollow microneedles.

Abstract: Fluid delivery and measurement systems and methods are disclosed.

Abstract: The microneedle devices disclosed herein in some embodiments include a substrate; one or more microneedles; and, optionally, a reservoir for delivery of drugs or collection of analyte, as well as pump(s), sensor(s), and/or microprocessor(s) to control the interaction of the foregoing. A switch or switching matrix may be connected to the microneedles to provide a switching mechanism for opening and closing a circuit coupled to the microneedle. A switch or switching matrix may be connected to the microneedle to provide a switching mechanisms for opening and closing a circuit coupled to the microneedle.

Abstract: Membrane containing microneedles, microneedle arrays, and needles, and systems and methods relating to same are disclosed.

Abstract: Fluid delivery and measurement systems and methods are disclosed.

Abstract: The invention in general relates to various injection systems and devices that can be used, for example, in needleless injection systems for human, and for domestic and farm animals. In certain embodiments, the invention provides an injection device comprising: an injector defining a first cavity and an orifice; a movable member in the first cavity; a housing defining a second cavity proximal of the movable member; and a charge in the second cavity, the charge comprising at least two discrete materials.

Abstract: Fluid delivery and measurement systems and methods are disclosed.

Abstract: Microneedle devices for transport of molecules, including drugs and biological molecules, across tissue, are provided. The microneedle devices permit drug delivery or removal of body fluids at clinically relevant rates across skin or other tissue barriers, with minimal or no damage, pain, or irritation to the tissue. Microneedles can be formed of biodegradable or non-biodegradable polymeric materials or metals. In a preferred embodiment, a microneedle device includes a plugging element comprising a platform including a plurality of microneedle plugs for preventing skin or other tissue barriers from entering the hollow microneedles. In another preferred embodiment, a microneedle device includes a plurality of bioerodible elements for temporarily plugging the hollow microneedles, thereby preventing skin or other tissue barriers from entering the hollow microneedles.

Abstract: Injection systems and devices that can be used in injection systems are disclosed.

Abstract: The microneedle devices disclosed herein in some embodiments include a substrate; one or more microneedles; a reservoir for delivery of drugs; a gas source, and, optionally, pump(s), sensor(s), and/or microprocessor(s) to control the interaction of the foregoing.

Abstract: The microneedle devices disclosed herein in some embodiments include a substrate; one or more microneedles; and, optionally, a reservoir for delivery of drugs or collection of analyte, as well as pump(s), sensor(s), and/or microprocessor(s) to control the interaction of the foregoing.

Abstract: Membrane containing microneedles, microneedle arrays, and needles, and systems and methods relating to same are disclosed.

Abstract: The microneedle devices disclosed herein in some embodiments include a substrate; one or more microneedles; and, optionally, a reservoir for delivery of drugs or collection of analyte, as well as pump(s), sensor(s), and/or microprocessor(s) to control the interaction of the foregoing. A switch or switching matrix may be connected to the microneedles to provide a switching mechanism for opening and closing a circuit coupled to the microneedle. A switch or switching matrix may be connected to the microneedle to provide a switching mechanisms for opening and closing a circuit coupled to the microneedle.

Abstract: Fluid delivery and measurement systems and methods are disclosed.

Abstract: Injection systems and devices that can be used in injection systems are disclosed.

Abstract: Injection systems and devices that can be used in injection systems are disclosed.

Abstract: Injection systems and devices that can be used in injection systems are disclosed.