Abstract: A product on demand nozzle assembly includes a chamber at least partially defined by an external wall and an array of vertically spaced nozzles. Each nozzle has an air inlet, an air and entrained product outlet extending from the external wall, and an entrainment zone between the air inlet and the air and entrained product outlet to receive a product therein to be distributed.

Abstract: The present disclosure provides vector stuffer polynucleotides and compositions thereof, including expression constructs and vectors, such as viral vectors and methods of delivering a therapeutic agent (e.g., inhibitory nucleic acid) to a mammal or treating a disease.

Abstract: Methods of identifying, diagnosing, and prognosing lupus, including certain subphenotypes of lupus, are provided, as well as methods of treating lupus, including certain subpopulations of patients. The methods provided are based on a set of alleles associated with systemic lupus erythematosus (SLE) risk loci including BLK, TNIP1, PRDM1, JAZF1, UHRF1BP1, IL10, IFIH1, CFB, CEC16A, IL12B and SH2B3 that contribute to SLE risk. Also provided are methods for identifying effective lupus therapeutic agents and predicting responsiveneness to lupus therapeutic agents.

Abstract: Provided herein are methods of treating a subject, methods of predicting the response of a subject and selecting a subject suffering from a disease associated with myeloid cell dysfunction. In particular, provided herein are methods for treatment or diagnosis of a disease associated with myeloid cell dysfunction, such as Alzheimer's Disease (AD) and Herpes Simplex Virus-1 (HSV-1) infection, with an agent specifically binding to Paired Immunoglobulin-like Type 2 Receptor Alpha (PILRA), such as an antibody as well as pharmaceutical formulations comprising the same.

Abstract: Methods of identifying, diagnosing, and prognosing lupus, including certain subphenotypes of lupus, are provided, as well as methods of treating lupus, including certain subpopulations of patients. The methods provided are based on a set of alleles associated with systemic lupus erythematosus (SLE) risk loci including BLK, TNIP1, PRDM1, JAZF1, UHRF1BP1, IL10, IFIH1, CFB, CEC16A, IL12B and SH2B3 that contribute to SLE risk. Also provided are methods for identifying effective lupus therapeutic agents and predicting responsiveness to lupus therapeutic agents.

Abstract: Methods of identifying, diagnosing, and prognosing lupus, including certain subphenotypes of lupus, are provided, as well as methods of treating lupus, including certain subpopulations of patients. The methods provided are based on a set of alleles associated with systemic lupus erythematosus (SLE) risk loci including BLK, TNIP1, PRDM1, JAZF1, UHRF1BP1, IL10, IFIH1, CFB, CEC16A, IL12B and SH2B3 that contribute to SLE risk. Also provided are methods for identifying effective lupus therapeutic agents and predicting responsiveness to lupus therapeutic agents.

Abstract: The invention provides methods of diagnosis and prognosis of Alzheimer' disease (AD) in a subject comprising detecting the presence or absence of one or more genetic variations in a sample from the subject, wherein the presence of the genetic variation indicates that the subject is afflicted with, or at risk of developing, AD. Methods of predicting the response of a subject to therapeutic agents for the treatment of AD are also provided.

Abstract: Methods of identifying, diagnosing, and prognosing lupus, including certain subphenotypes of lupus, are provided, as well as methods of treating lupus, including certain subpopulations of patients. The methods provided are based on a set of alleles associated with systemic lupus erythematosus (SLE) risk loci including BLK, TNIP1, PRDM1, JAZF1, UHRF1BP1, IL1 O, IFIH1, CFB, CEC16A, IL12B and SH2B3 that contribute to SLE risk. Also provided are methods for identifying effective lupus therapeutic agents and predicting responsiveness to lupus therapeutic agents.

Abstract: Methods and materials involved in diagnosing SLE are provided herein. The methods and materials can be used to diagnose SLE and/or assess a mammal's susceptibility to develop SLE, based on the presence or absence of one or more IRF-5 variants.

Abstract: Methods for determining whether a patient is at increased risk of developing wet AMD or whether a patient has an increased likelihood of benefiting from treatment with a high-affinity anti-VEGF antibody.

Abstract: A unique set of genetic variations associated with lupus are provided. Also provided are methods for detecting such genetic variations and for assessing risk of developing lupus as well as for diagnosing and treating lupus.

Abstract: Methods of identifying, diagnosing, and prognosing lupus, including certain subphenotypes of lupus, are provided, as well as methods of treating lupus, including certain subpopulations of patients. Also provided are methods for identifying effective lupus therapeutic agents and predicting responsiveness to lupus therapeutic agents.

Abstract: Methods and materials involved in diagnosing SLE are provided herein. The methods and materials can be used to diagnose SLE and/or assess a mammal's susceptibility to develop SLE, based on the presence or absence of one or more IRF-5 variants.

Abstract: The I-beam of this invention is formed from a pair of parallel flange members and a continuous web material affixed to and joining the flange members. The web material is formed so as to define a plurality of differently shaped holes therein that provide access for mechanical elements without compromising the compressive and tensile load capability of the I-beam. The web material is preferably formed from OSB and even more preferably ? inch thick OSB. In addition, the I-beam of this invention preferably has one end where the web material is continuous and does not define any openings therein. This portion of the I-beam thus allows the I-beam to be trimmed so standard lengths of the I-beam can be cut to the desired length for a particular application.

Abstract: The present invention may be used as an apparatus and method for extracting oil from a hydrocarbon material bearing formation. A well may be positioned in a formation having hydrocarbon material with a well casing extending into the formation that may have a number of apertures formed in the casing wall adjacent to multiple zones of interest in the formation. A hydrostatic separator may have a specific gravity approximately equal to an oil that may be extracted from the formation and may be positioned and anchored in the well casing above and adjacent to an upper level of said formation. An extraction pipe may be disposed interior to the well casing with a lower end positioned above and adjacent a separator top and may have an upper end attached at a well head. The well head may be in fluid communication with an oil storage unit and in communication with a pressure application apparatus.

Abstract: The present invention discloses a novel method and apparatus for instructing a student how to play a musical instrument. The method includes providing a display device, displaying a staff on the display device, displaying an image on the display device, and instructing the student to focus on the image while preferably using a musical instrument to play the notes on the staff, wherein the image moves generally in the direction of the progression of notes on the staff while the student attempts to play the, notes with the musical instrument. As the image moves, the image preferably moves in a direction generally parallel to the staff.

Abstract: A normally open gas supply safety valve sensitive to earthquake accelerations on x, y and z axes to displace a ball valve restrained by an arcuate groove with edges over which the ball valve rolls onto a seat for positive shut-off, including an abutment to ensure ball movement onto the seat, and including a leveler for installation.

Abstract: A fishing machine mounted on the side rail of a boat for automatically catching and boating fish. A rigid bracket is attached to the boat. The bracket has a base plate pivotally mounted thereon. A stator of a rotary actuator is attached to the base plate with its rotor supporting a hollow elongated fishing pole extending away from the boat to a fishing position over the water adjacent the outer deck periphery of the boat. A self-reciprocating hydraulic cylinder is attached between the bracket and the base plate to provide horizontal oscillational movement to the fishing pole. A fishing line with a fish catching lure at one end positioned below the surface of the water passes through the hollow fishing pole and its other end is attached to the control for the rotary actuator. Whn the weight of a fish is transmitted via the line to the rotary actuator control, the actuator rotor rotates in a manner to elevate the pole tip to a position over the deck of the boat.