Abstract: A blister strip advance mechanism includes: an indexing gear train; drive mechanism configured to drive the indexing gear train; and a hub including a recess shaped to engage a first blister of a blister strip, the hub being rotatable by the indexing gear train to engage the first blister in the recess and move the engaged blister strip such that a second blister is moved to a dosing position at which the second blister can be emptied; wherein the indexing gear train is configured to temporarily disengage the drive mechanism from the hub when the second blister is in the dosing position. Also disclosed is a dosing mechanism including the blister strip advance mechanism; an inhaler including the dosing mechanism; a method for advancing a blister strip; and a method for dosing a medicament including the method for advancing a blister strip.

Abstract: An adjustable stroller having a main carriage and a handle bar assembly, wherein the handle bar assembly is configured to convert between push and pull configurations to enable a user to either push or pull the stroller. More specifically, the adjustable stroller includes the main carriage, pulling rails comprised of handle bar tubes and telescoping rail tubes, two rear wheels attached to the main carriage and the proximal ends of the pulling rails via wheel hubs, a cross bar and center handle configured to host conversion and brake mechanism controls, and a third, front wheel to offer stability and balance. The handle bar assembly in dudes the pulling rails and the cross bar and center handle. In the pull configuration, the distal ends of the pulling rails can attach to an adjustable running belt that a user can wear around the user's waist.

Abstract: A blister strip advance mechanism includes: an indexing gear train; drive mechanism configured to drive the indexing gear train; and a hub including a recess shaped to engage a first blister of a blister strip, the hub being rotatable by the indexing gear train to engage the first blister in the recess and move the engaged blister strip such that a second blister is moved to a dosing position at which the second blister can be emptied; wherein the indexing gear train is configured to temporarily disengage the drive mechanism from the hub when the second blister is in the dosing position. Also disclosed is a dosing mechanism including the blister strip advance mechanism; an inhaler including the dosing mechanism; a method for advancing a blister strip; and a method for dosing a medicament including the method for advancing a blister strip.

Abstract: Films having peel seal layers and/or barrier layers are provided. In a general embodiment, the present disclosure provides a film comprising a barrier layer comprising a caprolactam-free nylon compound.

Abstract: Multilayer films comprising a core layer are provided. In an embodiment, the present disclosure provides a film having a core layer comprising a material selected from a rubber-modified polypropylene and a polymer blend. The polymer blend includes an elastomeric propylene-ethylene copolymer and a component selected from the group consisting of polypropylene random copolymers, styrene/ethylene-butylene/styrene block copolymers, and combinations thereof.

Abstract: A container for retaining a fluent therapeutic has a fluid transfer tube having a proximal end in fluid communication with an interior space of the container, a distal end accessible outside of the container and an inner surface defining a flow passage through which fluent therapeutic is delivered from the interior space of the container. At least a portion of the tube inner surface is textured such that the inner surface has a surface roughness equal to or greater than about 20 microinches. In a method for making such a container, the fluid transfer tube is extruded from an extruder and its inner surface is textured to have a surface roughness equal to or greater than about 20 microinches. The tube is secured to the container with a proximal end in fluid communication with the interior space of the container and a distal end accessible outside of the container.