Abstract: The present invention provides methods and devices for augmenting impaired glycocalyx barrier function in a subject in need thereof by contacting a sample (e.g., blood) obtained from the subject with a glycocalyx-mimetic adsorption media. The adsorption media includes glycosaminoglycan structures and, optionally, proteoglycan core proteins, which are conducive to enhancing and/or restoring the impaired glycocalyx barrier function in a sample. The contacted sample is subsequently separated from the adsorption media, producing a treated sample that can be infused into the subject. Methods and devices for treating a patient suffering from a disease associated with glycocalyx barrier dysfunction are also provided herein.

Abstract: The present invention provides methods and devices for augmenting impaired glycocalyx barrier function in a subject in need thereof by contacting a sample (e.g., blood) obtained from the subject with a glycocalyx-mimetic adsorption media. The adsorption media includes glycosaminoglycan structures and, optionally, proteoglycan core proteins, which are conducive to enhancing and/or restoring the impaired glycocalyx barrier function in a sample. The contacted sample is subsequently separated from the adsorption media, producing a treated sample that can be infused into the subject. Methods and devices for treating a patient suffering from a disease associated with glycocalyx barrier dysfunction are also provided herein.

Abstract: A system supports 50 ms protection switching times independent of network architecture. The system includes multiple protection switch fabrics to perform facility protection switching for the signals and a central switch fabric to switch a subset of the signals in a non-facility protection switching manner among the protection switch fabrics. Linear and ring network configurations are supported by the system. The system has flexibility to perform Linear Automatic Protection Switching (LAPS), Unidirection Path Switched Ring (UPSR) protection switching, and Bidirectional Line Switched Ring (BLSR) protection switching without burdening the central switch fabric with unnecessary or redundant traffic.

Abstract: A way of testing a wavelength division multiplexed (WDM) system without requiring connection to data source/sink equipment. A test signal is introduced onto a light path of interest in the system, and the test signal is monitored downstream for signal integrity. Lack of signal integrity is used to identify a fault in the lightpath. Alternatively, optical loopbacks may be used to localize and identify a fault in the lightpath. The lightpath includes a source optical node connected to a sink optical node via intermediate optical nodes. An optical signal introduced at the source node with a destination at the sink node may be looped back at any one of the intermediate nodes or the sink node to localize and identify a fault in the lightpath.

Abstract: Methods, apparatus and systems for regenerating, monitoring and bridging optical signals through an optical cross-connect switch to provide increased reliability. A self testing method, apparatus and system for an optical cross-connect switch. An optical-to-electrical-to-optical converter (O/E/O) is provided in an optical cross-connect switch to provide optical-electrical-optical conversion. I/O port cards having an optical-to-electrical-to-optical converter are referred to as smart port cards while I/O port cards without an optical-to-electrical-to-optical converter are referred to as passive port cards. Test port/monitor cards are also provided for testing optical cross-connect switches. Methods, apparatus and systems for performing bridging, test access, and supporting redundant optical switch fabrics are also disclosed.

Abstract: Methods, apparatus and systems for regenerating, monitoring and bridging optical signals through an optical cross-connect switch to provide increased reliability. A self testing method, apparatus and system for an optical cross-connect switch. An optical-to-electrical-to-optical converter (O/E/O) is provided in an optical cross-connect switch to provide optical-electrical-optical conversion. I/O port cards having an optical-to-electrical-to-optical converter are referred to as smart port cards while I/O port cards without an optical-to-electrical-to-optical converter are referred to as passive port cards. Test port/monitor cards are also provided for testing optical cross-connect switches. Methods, apparatus and systems for performing bridging, test access, and supporting redundant optical switch fabrics are also disclosed.

Abstract: Methods, apparatus and systems for regenerating, monitoring and bridging optical signals through an optical cross-connect switch to provide increased reliability. A self testing method, apparatus and system for an optical cross-connect switch. An optical-to-electrical-to-optical converter (O/E/O) is provided in an optical cross-connect switch to provide optical-electrical-optical conversion. I/O port cards having an optical-to-electrical-to-optical converter are referred to as smart port cards while I/O port cards without an optical-to-electrical-to-optical converter are referred to as passive port cards. Test port/monitor cards are also provided for testing optical cross-connect switches. Methods, apparatus and systems for performing bridging, test access, and supporting redundant optical switch fabrics are also disclosed.

Abstract: Methods, apparatus and systems for regenerating, monitoring and bridging optical signals through an optical cross-connect switch to provide increased reliability. A self testing method, apparatus and system for an optical cross-connect switch. An optical-to-electrical-to-optical converter (O/E/O) is provided in an optical cross-connect switch to provide optical-electrical-optical conversion. I/O port cards having an optical-to-electrical-to-optical converter are referred to as smart port cards while I/O port cards without an optical-to-electrical-to-optical converter are referred to as passive port cards. Test port/monitor cards are also provided for testing optical cross-connect switches. Methods, apparatus and systems for performing bridging, test access, and supporting redundant optical switch fabrics are also disclosed.

Abstract: A system supports 50 ms protection switching times independent of network architecture. The system includes multiple protection switch fabrics to perform facility protection switching for the signals and a central switch fabric to switch a subset of the signals in a non-facility protection switching manner among the protection switch fabrics. Linear and ring network configurations are supported by the system. The system has flexibility to perform Linear Automatic Protection Switching (LAPS), Unidirection Path Switched Ring (UPSR) protection switching, and Bidirectional Line Switched Ring (BLSR) protection switching without burdening the central switch fabric with unnecessary or redundant traffic.

Abstract: Methods, apparatus and systems for regenerating, monitoring and bridging optical signals through an optical cross-connect switch to provide increased reliability. A self testing method, apparatus and system for an optical cross-connect switch. An optical-to-electrical-to-optical converter (O/E/O) is provided in an optical cross-connect switch to provide optical-electrical-optical conversion. I/O port cards having an optical-to-electrical-to-optical converter are referred to as smart port cards while I/O port cards without an optical-to-electrical-to-optical converter are referred to as passive port cards. Test port/monitor cards are also provided for testing optical cross-connect switches. Methods, apparatus and systems for performing bridging, test access, and supporting redundant optical switch fabrics are also disclosed.

Abstract: Methods, apparatus and systems for regenerating, monitoring and bridging optical signals through an optical cross-connect switch to provide increased reliability. A self testing method, apparatus and system for an optical cross-connect switch. An optical-to-electrical-to-optical converter (O/E/O) is provided in an optical cross-connect switch to provide optical-electrical-optical conversion. I/O port cards having an optical-to-electrical-to-optical converter are referred to as smart port cards while I/O port cards without an optical-to-electrical-to-optical converter are referred to as passive port cards. Test port/monitor cards are also provided for testing optical cross-connect switches. Methods, apparatus and systems for performing bridging, test access, and supporting redundant optical switch fabrics are also disclosed.

Abstract: Methods, apparatus and systems for regenerating, monitoring and bridging optical signals through an optical cross-connect switch to provide increased reliability. A self testing method, apparatus and system for an optical cross-connect switch. An optical-to-electrical-to-optical converter (O/E/O) is provided in an optical cross-connect switch to provide optical-electrical-optical conversion. I/O port cards having an optical-to-electrical-to-optical converter are referred to as smart port cards while I/O port cards without an optical-to-electrical-to-optical converter are referred to as passive port cards. Test port/monitor cards are also provided for testing optical cross-connect switches. Methods, apparatus and systems for performing bridging, test access, and supporting redundant optical switch fabrics are also disclosed.

Abstract: In one embodiment, a scalable cross-connect switching system and its corresponding method perform a bridging operation by splitting the incoming light signal into at least a first bridged light signal and a second bridged light signal. The first bridged light signal has a power level equal to or substantially greater than a power level of the second bridged light signal. The disproportionate power levels provide low-loss bridging. Light signals based on these bridged light signals are routed through multiple switch fabrics which provide redundancy in case of failure by switching within the switch fabric. To detect failures, a test access port is configured for monitoring multiple optical paths.

Abstract: In general, an optical cross-connect switching system comprising a switch subsystem, an input/output (I/O) subsystem including a plurality of removable, I/O port modules, and a switch control subsystem featuring servo modules. These units collectively operate to provide optical data paths for routing of light signals without conversion from optical to electrical domains and back to optical. Also, the optical cross-connect switching system is scalable because the I/O port modules, servo modules and even features of the switch subsystem may be removed without disruption in system operation.

Abstract: Processes are disclosed for coating the exteriors of a plurality of hollow fibers which are suitable for fluid separations and which are assembled in the form of a bundle. The processes involve immersing the bundle of hollow fibers in a coating liquid containing material suitable for forming the coating and a substantial amount of solvent. A pressure drop from the exteriors to the interiors of the hollow fibers is provided to result in the formation of a deposit on the exteriors of the hollow fibers. The processes of this invention enable essentially the entire exterior surfaces of the hollow fibers to be coated without undue sticking of the hollow fibers or providing undesirably thick coatings on the hollow fibers in any portion of the bundle or on a portion of any of the hollow fibers.

Abstract: The selectivities of fluid separations of membranes having pores, in which the material of the membranes significantly effects the fluid separations, can be enhanced by the storage of the membranes in water. Suitable materials of the membranes for improvement in accordance with this invention are those which are not unduly susceptible to biodegradation. The membranes for improvement in accordance with this invention preferably have structures which are not unduly affected by drying and thus maintain beneficial mechanical and fluid separation properties after drying.