Patents by Inventor Robert R. Yocum

Robert R. Yocum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hybrid yeast promoter comprising an ENO2 UAS and TATA region and an additional UAS located between said ENO2 UAS and TATA region
    Patent number: 5541084
    Abstract: A DNA sequence having a yeast ENO2 promoter functionally fused to a heterologous gene.
    Type: Grant
    Filed: June 12, 1992
    Date of Patent: July 30, 1996
    Assignee: Robert R. Yocum
    Inventors: Scott Van Arsdell, Robert S. Daves, Robert R. Yocum
  • Ligase chain reaction with endonuclease IV correction and contamination control
    Patent number: 5516663
    Abstract: The present invention involves methods of improving the Ligase Chain Reaction (LCR.TM.) amplification schemes by modifying at least one probe end so that the probability of the probe contributing to spurious ligation and signal development is greatly reduced. Only after specific hybridization of the modified probe with true target are the modified ends "corrected" by endonuclease IV in a target dependent fashion to allow participation of the probe in the enzymatic ligation reaction. Specific modifications include 3' phosphate blocking groups and nucleic acid overhangs containing an abasic site at the point of ligation. Further embodiments include probes modified to contain ribonucleotide moieties which, after amplification, can be cleaved by RNase to destroy the amplification products and reduce the risk of contamination.
    Type: Grant
    Filed: April 19, 1993
    Date of Patent: May 14, 1996
    Assignee: Abbott Laboratories
    Inventors: Keith C. Backman, John J. Carrino, George H. Shimer, Robert R. Yocum
  • Industrial yeast comprising an integrated glucoamylase gene
    Patent number: 5422267
    Abstract: A vector having a gene for resistance to an antibiotic otherwise capable of killing a host yeast cell, the gene being transcribed from a yeast promoter sequence and the vector being capable of being integrated into a chromosome of the host yeast cell; and a diploid or greater ploidy yeast cell transformed by such a vector with heterologous DNA.
    Type: Grant
    Filed: January 24, 1990
    Date of Patent: June 6, 1995
    Assignee: Robert R. Yocum
    Inventors: Robert R. Yocum, Robert S. Daves, Michael C. Chen
  • Expression and secretion vector for yeast containing a glucoamylase signal sequence
    Patent number: 5024941
    Abstract: A vector including a DNA sequence encoding a secretory signal sequence substantially identical to the secretory signal-encoding sequence of a glucoamylase gene from Saccharomyces diastaticus or S. cerevisiae; and upstream from the signal-encoding sequence, a DNA sequence capable of promoting transcription in yeast (e.g., a high yield promoter, such as the promoter of the triose phosphate isomerase gene), transcription of the signal-encoding sequence being under the control of the transcription-promoting sequence, a site for the insertion into the vector of a heterologous DNA sequence, in reading frame with the signal-encoding sequence. The vector is useful as an expression vector in yeast.
    Type: Grant
    Filed: December 18, 1985
    Date of Patent: June 18, 1991
    Assignee: BioTechnica International, Inc.
    Inventors: Gregory T. Maine, Robert S. Daves, Robert R. Yocum
  • Acidic phallotoxin derivatives and methods of preparation
    Patent number: 4489001
    Abstract: The present invention relates to novel compounds which are derivatives of acidic phallotoxins and correspond to the formula: ##STR1## (NBD-acid phallotoxins) their preparation, and their use in fluorescent staining of F-actin.
    Type: Grant
    Filed: March 18, 1983
    Date of Patent: December 18, 1984
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Lawrence S. Barak, Eugene A. Nothnagel, Watt W. Webb, Robert R. Yocum
  • NBD-Acidic phallotoxins and their use in the fluorescence staining of F-actin
    Patent number: 4387088
    Abstract: The present invention relates to novel compounds which are derivatives of acidic phallotoxins and correspond to the formula: ##STR1## (NBD-acid phallotoxins) their preparation, and their use in fluorescent staining of F-actin.
    Type: Grant
    Filed: February 25, 1980
    Date of Patent: June 7, 1983
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Lawrence S. Barak, Eugene A. Nothnagel, Watt W. Webb, Robert R. Yocum