Abstract: The invention relates generally to conjugated activatable antibodies that bind CD71 in their active form and methods of making and using these anti-CD71 conjugated activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.

Abstract: A fall restricting system for use by a person having a ladder, a stabilizing system adapted to engage the ladder and ground and an anchoring system adapted to engage the ladder and the person.

Abstract: Disclosed are medicaments, pharmaceutical compositions, pharmaceutical kits, and methods based on combinations comprising, separately or together: (a) a CYP3A4 inhibitor; and (b) a HCV protease inhibitor; for concurrent or consecutive administration in treating a human subject infected with HCV.

Abstract: Novel hepatitis C virus (“HCV”) inhibitor combinations comprising an HCV protease inhibitor and HCV polymerase inhibitor, and optionally one or more biologically active agents, as well as uses of these combinations as HCV inhibitors and for treating hepatitis C and related disorders are disclosed.

Abstract: The present invention provides cell lines for the production of E1-deleted adenovirus (rAd) vectors that complement E1A and E1B functions. The present invention also provides cell lines for the production of E1- and E2-deleted adenovirus vectors that complement E1A, E1B and E2B polymerase functions. The invention provides particular cell lines that complement E1A function by insertion of an E1A sequence containing mutations in the 243R and 289R proteins and an E1B sequence comprising the E1B-55K gene. Production yields in the resulting producer cell lines, designated SL0003 and SL0006, were similar to those obtained from 293 cells without generation of detectable recombinant replication competent adenovirus (“RCA”).

Abstract: Two Hepatitis C Virus envelope proteins (E1 and E2) are expressed without sialylation. Recombinant expression of these proteins in lower eukaryotes, or in mammalian cells in which terminal glycosylation is blocked, results in recombinant proteins which are more similar to native HCV glycoproteins. When isolated by GNA lectin affinity, the E1 and E2 proteins aggregate into virus-like particles.

Abstract: Plasmid expression systems for delivery of DNA coding sequences to a mammal are described which provide expression of human IL-2. Also described are particular lipid/DNA delivery systems having advantageous characteristics of size, charge ratio, and proportion of supercoiled DNA, and methods of preparing and using such delivery systems for treatment.

Abstract: An adjustable stablizing device which is attached to an extension ladder having hollow rungs without requiring modification of the ladder structure or affecting normal operation of the ladder is described. The device has two stabilizing elements made of aluminum which are located at different side of the ladder. Each stabilizing element has an upper and a lower bracket which are connected together by two rigid pivotably-linked longitudinal members. The stabilizing elements are connected to each other by rods which extend through the hollow rungs of the ladder and which connect the upper and the lower brackets. The lower bracket and the lower longitudinal member are pivotably connected, and the upper bracket has a number of apertures spaced lengthwise of the ladder. By choosing the aperture to which the upper longitudinal member is connected, the attitude of each of the lower members is varied via the pivotable connection so as to lie on the surface adjacent the ladder side.

Abstract: A process for preparing pyridinium chloride salts of esters of 2-chloro-N-2-hydroxyethylacetamide in which no intermediates need be isolated is disclosed.