Abstract: An apparatus (10) for performing microfluidic processes comprising a base (50), a plurality of fluidic modules (20) releasably attached to the base (50), each fluidic module (20) comprising a fluid port (25) and a microfluidic manifold module (40) comprising a plurality of ports (45). A frame (70) is attached to the base (50) for releasably retaining the microfluidic manifold module (40), the frame (70) being moveable relatively to the base (50) to move the microfluidic manifold module (40) into contact with the fluidic modules (20) such that each fluid port (25) of the fluidic modules (20) aligns and seals with a respective port (45) on the microfluidic manifold module (40) thus completing a microfluidic circuit. A method for constructing and testing the apparatus (10) is also disclosed.