Abstract: Provided are modified isolated ADAM10 modulating peptides and methods of using the same to modulate ADAM10 biological activities, inhibit ADAM10 biological activities associated with diseases, disorders, or conditions in subjects, including but not limited to decreasing inflammation and inhibiting undesirable cell proliferation. In some embodiments, the modified isolated ADAM10 modulating peptides are based on SEQ ID NO: 3 or SEQ ID NO: 4, and in some embodiments include modifications at or near the N-terminal and/or the C-terminal ends of the disclosed peptides as well as substitutions, insertions, and deletions at one or more amino acid positions of the ADAM10 prodomain peptides disclosed herein.

Abstract: Provided are ADAM9 modulating peptides and methods for using the same to modulate ADAM9 biological activities in vitro and/or in vivo, to inhibit ADAM9 biological activities associated with diseases or disorders in subjects, to decrease inflammation, and to inhibit undesirable cellular proliferation, fibrosis, and angiogenesis. In some embodiments, the ADAM9 modulating peptides include modifications of one or more amino acids of the human ADAM9 prodomain amino acid sequence, and in some embodiments the ADAM9 modulating peptides include other modifications such as but not limited to the addition of PEG groups.

Abstract: Provided are modified isolated ADAM10 modulating peptides and methods of using the same to modulate ADAM10 biological activities, inhibit ADAM10 biological activities associated with diseases, disorders, or conditions in subjects, including but not limited to decreasing inflammation and inhibiting undesirable cell proliferation. In some embodiments, the modified isolated ADAM10 modulating peptides are based on SEQ ID NO: 3 or SEQ ID NO: 4, and in some embodiments include modifications at or near the N-terminal and/or the C-terminal ends of the disclosed peptides as well as substitutions, insertions, and deletions at one or more amino acid positions of the ADAM10 prodomain peptides disclosed herein.

Abstract: Provided are ADAM9 modulating peptides and methods for using the same to modulate ADAM9 biological activities in vitro and/or in vivo, to inhibit ADAM9 biological activities associated with diseases or disorders in subjects, to decrease inflammation, and to inhibit undesirable cellular proliferation, fibrosis, and angiogenesis. In some embodiments, the ADAM9 modulating peptides include modifications of one or more amino acids of the human ADAM9 prodomain amino acid sequence, and in some embodiments the ADAM9 modulating peptides include other modifications such as but not limited to the addition of PEG groups.

Abstract: Provided are modified isolated ADAM10 modulating peptides and methods of using the same to modulate ADAM10 biological activities, inhibit ADAM10 biological activities associated with diseases, disorders, or conditions in subjects, including but not limited to decreasing inflammation and inhibiting undesirablecell proliferation. In some embodiments, the modified isolated ADAM10 modulating peptides are based on SEQ ID NO: 3 or SEQ ID NO: 4, and in some embodiments include modifications at or near the N-terminal and/or the C-terminal ends of the disclosed peptides as well as substitutions, insertions, and deletions at one or more amino acid positions of the ADAM10 prodomain peptides disclosed herein.

Abstract: This disclosure provides ADAM8 modulating peptides, nucleic acids encoding ADAM8 modulating peptides, and methods for using the same to modulate ADAM8 biological activities in vitro and/or in vivo, to inhibit ADAM8 biological activities associated with diseases or disorders in subjects including gene therapy or cell based therapies. Specifically, methods are provided to decrease inflammation, and to inhibit undesirable cellular proliferation, fibrosis, and angiogenesis. In some embodiments, the ADAM8 modulating peptides or nucleic acids encoding them include modifications of one or more amino acids of the human ADAM8 prodomain amino acid sequence, and in some embodiments the ADAM8 modulating peptides include other modifications such as but not limited to the addition of PEG groups.

Abstract: Mattress assemblies are disclosed herein. The mattress assemblies can include a multilayered construction having a base layer, a coil layer, and a zoned cushioning layer. The zoned cushioning layer can include two or more cushioning members made of an elastomeric cushioning material. The cushioning members can be disposed in a hip region, a shoulder region, and/or a leg region of the mattress assembly. One or more support and/or comfort layers can also be included.

Abstract: Provided are ADAM9 modulating peptides and methods for using the same to modulate ADAM9 biological activities in vitro and/or in vivo, to inhibit ADAM9 biological activities associated with diseases or disorders in subjects, to decrease inflammation, and to inhibit undesirable cellular proliferation, fibrosis, and angiogenesis. In some embodiments, the ADAM9 modulating peptides include modifications of one or more amino acids of the human ADAM9 prodomain amino acid sequence, and in some embodiments the ADAM9 modulating peptides include other modifications such as but not limited to the addition of PEG groups.

Abstract: Provided are modified isolated ADAM10 modulating peptides and methods of using the same to modulate ADAM10 biological activities, inhibit ADAM10 biological activities associated with diseases, disorders, or conditions in subjects, including but not limited to decreasing inflammation and inhibiting undesirable cell proliferation. In some embodiments, the modified isolated ADAM10 modulating peptides are based on SEQ ID NO: 3 or SEQ ID NO: 4, and in some embodiments include modifications at or near the N-terminal and/or the C-terminal ends of the disclosed peptides as well as substitutions, insertions, and deletions at one or more amino acid positions of the ADAM10 prodomain peptides disclosed herein.

Abstract: A one-piece piston having an investment or other permanent or non-permanent mold/die precision cast piston crown, rod flange and piston skirt. The piston crown has a relative constant thickness, a flange requiring minimal machining and a skirt providing for a wall with a support against the angular shifting of the piston. This improves the distribution of heat within such crown and the angular stability of the piston wall at the piston rod connection.

Abstract: A one-piece piston having an investment or other permanent or non-permanent mold/die precision cast piston crown, rod flange and piston skirt. The piston crown has a relative constant thickness, a flange requiring minimal machining and a skirt providing for a wall with a support against the angular shifting of the piston. This improves the distribution of heat within such crown and the angular stability of the piston wall at the piston rod connection.

Abstract: A one-piece piston having an investment or other permanent or non-permanent mold/die precision cast piston crown, rod flange and piston skirt. The piston crown has a relative constant thickness, a flange requiring minimal machining and a skirt providing for a wall with a support against the angular shifting of the piston. This improves the distribution of heat within such crown and the angular stability of the piston wall at the piston rod connection.

Abstract: This invention relates to an articulated two piece piston designed for reciprocable movement within a combustion chamber of an internal combustion engine. The piston has a crown of high-strength ferrous material that is precision cast net to finished dimensions on all inner and outer surfaces to provide a controlled thickness throughout to ensure mechanical and thermal consistency without any additional machining of the crown. The crown is attached to a separate skirt by the use of a wrist pin, wherein the skirt is made of ferrous or non-ferrous materials by casting or other means.

Abstract: A method for removing impurities (e.g., atomic sulfur) from a reticle for use in photolithography is provided. In one embodiment, a reticle (or photomask) comprising a plate, a first layer over the plate, and a photoresist layer over the first layer is provided. The photoresist layer is removed with a first chemistry comprising a sulfur-containing compound. At least a portion of the first layer is removed with a second chemistry comprising a sulfur-containing etchant, thereby exposing portions of the plate. Removing the photoresist layer and/or at least a portion of the first layer leaves sulfur on at least portions of the reticle. In a cleaning step, the reticle is contacted with one or more excited species of oxygen to remove residual sulfur and other contaminants, such as carbon, sulfur and oxygen-containing species. Methods of embodiments can be used to clean, e.g., binary photomasks, attenuated phase shift masks (APSMs) and high transmission attenuated photomasks.

Abstract: A method of forming integrated circuit structures, such as capacitors and conductive plugs, within contact openings formed in a photosensitive silicone ladder polymer (PVSQ) is disclosed. Contact openings with reduced striations and CD loss are formed in a photosensitive silicone ladder polymer (PVSQ) layer by patterning the PVSQ film employing a photomask with a predefined pattern, exposing the PVSQ film to i-line, developing the exposed PVSQ film in a mixture of anisole/xylene in a ratio of about 1:2 for about 30 seconds, and subsequently optionally annealing the undeveloped PVSQ film at a temperature of about 300° C. to about 600° C.

Abstract: This invention relates to an articulated two piece piston designed for reciprocable movement within a combustion chamber of an internal combustion engine. The piston has a crown of high-strength ferrous material that is precision cast net to finished dimensions on all inner and outer surfaces to provide a controlled thickness throughout to ensure mechanical and thermal consistency without any additional machining of the crown. The crown is attached to a separate skirt by the use of a wrist pin, wherein the skirt is made of ferrous or non-ferrous materials by casting or other means.

Abstract: A method for removing impurities (e.g., atomic sulfur) from a reticle for use in photolithography is provided. In one embodiment, a reticle (or photomask) comprising a plate, a first layer over the plate, and a photoresist layer over the first layer is provided. The photoresist layer is removed with a first chemistry comprising a sulfur-containing compound. At least a portion of the first layer is removed with a second chemistry comprising a sulfur-containing etchant, thereby exposing portions of the plate. Removing the photoresist layer and/or at least a portion of the first layer leaves sulfur on at least portions of the reticle. In a cleaning step, the reticle is contacted with one or more excited species of oxygen to remove residual sulfur and other contaminants, such as carbon, sulfur and oxygen-containing species. Methods of embodiments can be used to clean, e.g., binary photomasks, attenuated phase shift masks (APSMs) and high transmission attenuated photomasks.

Abstract: A ductile repair cylinder liner for a diesel engine, the cylinder liner having an additional cooling groove with a parabolic varying cross-section machined into the outer surface of the cylinder liner immediately below the radially extending locating flange for the liner.

Abstract: A one-piece piston having an investment or other permanent or non-permanent mold/die precision cast piston crown, rod flange and piston skirt. The piston crown has a relative constant thickness, a flange requiring minimal machining and a skirt providing for a wall with a support against the angular shifting of the piston. This improves the distribution of heat within such crown and the angular stability of the piston wall at the piston rod connection.

Abstract: A flat panel field emission device includes a black matrix formed from an electrically insulative material such as praseodymium-manganese oxide. The insulative black matrix increases image contrast and reduces power consumption. For field emission devices which utilize a switched anode for selectively activating pixels, the insulative material reduces or eliminates problems associated with short circuiting of the pixels.