Abstract: The present invention relates to peptide conjugates of microtubule-targeting agents such as maytansinoid derivatives which are useful for the treatment of diseases such as cancer.

Abstract: The disclosure generally relates to ultra high molecular weight poly(ethylene) (“UHMWPE”) tubes with an average wall thickness of 0.2 mm or less; a tensile stress at break greater than 40 MPa; and a storage modulus of greater than 500 MPa at 23° C. The disclosure further relates to preparing and using such tubes and to constructions (e.g., catheter constructions) and components thereof including such tubes.

Abstract: Systems, methods and apparatuses of predictive maintenance of automotive transmission of vehicles. For example, the transmission has at least one sensor to measure a temperature in transmission fluid, the torque applied on a shaft of the transmission, a vibration sensor, and/or a microphone. During a period in which the vehicle is assumed to be operating normally, the sensor data generated by the transmission sensor(s) is used to train an artificial neural network to recognize the normal patterns in the sensor data. Subsequently, the trained artificial neural network is used to determine whether the current sensor data from the transmission sensor(s) are abnormal. A maintenance alert can be generated for the vehicle in response to a determination that the operations of the transmission are abnormal according to the artificial neural network and the current sensor data.

Abstract: A cross-flow interconnect and a fuel cell stack including the same, the interconnect including fuel inlets and outlets that extend through the interconnect adjacent to opposing first and second peripheral edges of the interconnect; an air side; and an opposing fuel side. The air side includes an air flow field including air channels that extend in a first direction, from a third peripheral edge of the interconnect to an opposing fourth peripheral edge of the interconnect; and riser seal surfaces disposed on two opposing sides of the air flow field and in which the fuel inlets and outlets are formed. The fuel side includes a fuel flow field including fuel channels that extend in a second direction substantially perpendicular to the first direction, between the fuel inlets and outlets; and a perimeter seal surface surrounding the fuel flow field and the fuel inlets and outlets.

Abstract: The present disclosure describes a cable mounting bracket, The bracket includes a pair of clamping members configured to be secured to a mounting structure, a pair of rods extending outwardly from the pair of clamping members, and a main panel comprising a plurality of apertures, each aperture being configured to receive and secure a cable hanger to the main panel. The pair of rods couples the main panel with the pair of clamping members and positions the main panel a distance from the mounting structure.

Abstract: The present disclosure provides extruded PTFE composite tubes with a reduced coefficient of friction (COF). In some embodiments, such extruded PTFE composite tubes may exhibit a reduced change in coefficient of friction between about 20° C. and about 40° C. with the inclusion of secondary polymeric particles with small particle sizes (<100 ?m) at loading percentages of less than about 50 weight %.

Abstract: A wearable display system includes a light projection system having one or more emissive microdisplays, e.g., micro-LED displays. The light projection system projects time-multiplexed left-eye and right-eye images, which pass through an optical router having a polarizer and a switchable polarization rotator. The optical router is synchronized with the generation of images by the light projection system to impart a first polarization to left-eye images and a second different polarization to right-eye images. Light of the first polarization is incoupled into an eyepiece having one or more waveguides for outputting light to one of the left and right eyes, while light of the second polarization may be incoupled into another eyepiece having one or more waveguides for outputting light to the other of the left and right eyes. Each eyepiece may output incoupled light with variable amounts of wavefront divergence, to elicit different accommodation responses from the user's eyes.

Abstract: An apparatus for preparing fruit includes a main housing with a cutting area containing a cutting assembly and a drive assembly, a removable cup assembly for inserting the fruit into the apparatus, and a removable drawer and tray for removing cut pieces of fruit from the apparatus after a cutting operation. The apparatus includes a rinsing assembly for cleaning the fruit and the cutting assembly, and a deflector configured to route cut pieces of fruit into the tray and waste material through a disposal outlet. The cutting assembly is configured to perform one or more cutting operations depending on the type of fruit detected in the cup assembly: wedging for apples, lemons, limes, and pears, and cutting/peeling for oranges and grapefruits. The apparatus quickly prepares various fruits for consumption without requiring an operator to touch the cut pieces of fruit.

Abstract: A modular plumbing system having one or more carriers each attached to a carrier mount that may be joined to one or more base rails. The modular plumbing system may be transported to a construction site fully assembled and ready to be installed by anchoring the plumbing system to a floor and connecting plumbing lines within the plumbing system to existing plumbing lines.

Abstract: A device having a plurality of pins configured to connect circuits within an integrated circuit package to circuits outside of the integrated circuit package. A driver enclosed within the package is programmable to generate a spread spectrum signal to represent data being transmitted from a pin of the device. Frequency distribution of the signal spreading over a bandwidth in a frequency domain can be programmed to customize the electromagnetic emission caused by the communication of data through the pin. The frequency spreading can be programmed to reduce energy consumption, electromagnetic interference, and/or errors in receiving the data transmitted via the pin. The settings can be programmed into registers enclosed in the integrated circuit package to control the driver and/or dynamically adjusted using an artificial intelligent engine to optimize a cost function.

Abstract: When a mobile device is securely connected to a vehicle, at least a portion of a control interface of the vehicle can be extended to the mobile device, allowing a user of the mobile device to operate certain functions of the vehicle from the mobile device. For example, a passenger of a vehicle can control some aspects of the vehicle, while the driver controls driving aspects. Optionally, the passenger can take the role of a co-driver or co-pilot of the vehicle in some embodiments.

Abstract: The system includes a frame composed of materials and geometry allowing selective deformation in a plane perpendicular to a patient's anatomy at the surgical site but resisting deformation in a plane parallel to the anatomy. The frame is connected to stabilizing features and sheets, which are attached to adhesive to secure the frame to the patient. The features, sheets, and adhesive layers extend both into and beyond the frame. An integrated sheet covers the prospective incision site on the patient. When positioned at the site, the frame conforms to the patient. Anchor points are distributed along the frame to reversibly secure and provide a stable base for surgical retractors, even when unilaterally applied. By adaptable positioning and design of the stabilizing members and adhesive layers on the frame, the system is able to provide optimal tractional stability when experiencing tensile loads in myriad surgical environments including ophthalmic and spinal surgery.

Abstract: Systems, methods and apparatus of predictive maintenance of automotive tires. For example, a vehicle has: a tire and wheel assembly; one or more sensors configured on the tire and wheel assembly to measure operating parameters of the tire and wheel assembly; an artificial neural network configured to analyze the operating parameters of the tire and wheel assembly as a function of time to generate a result; and at least one processor configured to generate a suggestion for a maintenance service of the tire and wheel assembly based on the result from the artificial neural network analyzing the operating parameters of the tire and wheel assembly. For example, the sensors can be configured to measure a pressure of air in the tire, a temperature of the air in the tire, a speed of spinning of the wheel, a traction force or torque applied by the wheel on an axle of the vehicle, and/or vibration of the wheel.

Abstract: A vehicle or a mobile device within or near the vehicle can have multiple sensors to sense biometric features of a user or driver, and electronic circuitry (such as a computing system) can classify the user or driver according to the sensed biometric features. Also, non-biometric factors of the user or driver or of the mobile device of the user or driver can be used to classify the user or driver, e.g., MAC address, RFID, username and password, PIN, etc. Also, factors from interaction with a user interface of the vehicle or the mobile device can be used to classify the user or driver. Such features and factors can be used alone or in combination for the classification, and the classification can use AI (such as an ANN). The vehicle or the mobile device can then selectively enable or disable features of the vehicle based on the classification.

Abstract: Systems and methods for characterizing a driving style of a human driver are presented. A system may include one or more sensors configured to collect information concerning driving characteristics associated with operation of a vehicle by a human; a memory containing computer-readable instructions for evaluating the information concerning driving characteristics collected by the one or more sensors for one or more patterns correlatable with a driving style of the human and for characterizing aspects of the driving style of the human based on the one or more patterns; and a processor configured to read the computer-readable instructions from the memory, evaluate the driving characteristics collected by the one or more sensors for one or more patterns correlatable with a driving style of the human, and characterize aspects of the driving style of the human based on the one or more patterns. Corresponding methods and non-transitory media are disclosed.

Abstract: A vehicle or a mobile device within or near the vehicle can have multiple sensors to authenticate a passenger or driver of the vehicle in different ways, e.g., fingerprint, facial recognition, voice fingerprinting, iris scan, etc. Also, non-biometric factors can be used to authenticate the passenger or driver of the vehicle, e.g., MAC address, RFID, username and password, PIN, etc. In addition, a network attached security asset accessed by a vehicle can be included within the vehicle such as modem within the vehicle with authentication capabilities. Also, the authentication can be according to a zero trust framework or networking methodology. Some or all of such credentials and authentication factors or methods can fail individually, at least in part, in various conditions. An intelligent system, making use of intelligent multi-factor authentication, can combine such information to determine the identity of the passenger or driver with more reliability.

Abstract: Systems, methods and apparatuses of predictive maintenance of automotive transmission of vehicles. For example, the transmission has at least one sensor to measure a temperature in transmission fluid, the torque applied on a shaft of the transmission, a vibration sensor, and/or a microphone. During a period in which the vehicle is assumed to be operating normally, the sensor data generated by the transmission sensor(s) is used to train an artificial neural network to recognize the normal patterns in the sensor data. Subsequently, the trained artificial neural network is used to determine whether the current sensor data from the transmission sensor(s) are abnormal. A maintenance alert can be generated for the vehicle in response to a determination that the operations of the transmission are abnormal according to the artificial neural network and the current sensor data.

Abstract: Systems, methods and apparatuses to detect an item left in a vehicle and to generate an alert about the item. For example, a camera configured in a vehicle can be used to monitor an item associated with a user of the vehicle. The item as in an image from the camera can be identified and recognized using an artificial neural network. In response to a determination that the item recognized in the image is left in the vehicle after the user has exited the vehicle, an alert is generated to indicate that an item is in the vehicle but the user is leaving the vehicle.

Abstract: The system includes a frame composed of materials and geometry allowing selective deformation in a plane perpendicular to a patient's anatomy at the surgical site but resisting deformation in a plane parallel to the anatomy. The frame is connected to stabilizing features and sheets, which are attached to adhesive to secure the frame to the patient. The features, sheets, and adhesive layers extend both into and beyond the frame. An integrated sheet covers the prospective incision site on the patient. When positioned at the site, the frame conforms to the patient. Anchor points are distributed along the frame to reversibly secure and provide a stable base for surgical retractors, even when unilaterally applied. By adaptable positioning and design of the stabilizing members and adhesive layers on the frame, the system is able to provide optimal tractional stability when experiencing tensile loads in myriad surgical environments including ophthalmic and spinal surgery.

Abstract: Apparatuses and methods for heating moving continuous glass ribbons at desired lines of separation and/or for separating glass sheets from continuous glass ribbons are disclosed. An apparatus includes a translatable support portion and a heating apparatus coupled to the support portion. The heating apparatus is configured to contact the continuous glass ribbon across at least a portion of a width of the continuous glass ribbon at the desired line of separation as the support portion moves in a draw direction, thereby preferentially applying heat to a first side of the continuous glass ribbon at the desired line of separation as the continuous glass ribbon moves in the draw direction.