Abstract: The present invention provides compositions and methods for treating a neuromuscular disorder. In certain embodiments, the invention provides compositions and methods for assessing weaning readiness and continuation of weaning off of a mechanical ventilator in a subject with X-linked myotubular myopathy (XLMTM).

Abstract: The present invention can provide a glove system that mounts with a user's hand and facilitates efficient hand-actuated repetitive motions, such as sanding. A tool element removeably mounts with a glove, and provides for easy tool changes, while the mounting allows force to be transmitted from the hand to the tool without continued gripping or pinching by the user. Actions such as sanding can be accomplished with more force, and less user fatigue.

Abstract: At least one feature provides a fall arrest device for securing a user. The fall arrest device comprises a primary support member adapted to couple to a doorway, a security line having a first end adapted to couple to the primary support member, and a harness adapted to couple to a second end of the security line. The primary support member includes a first support member adapted to secure the primary support member to a first surface of a wall of the doorway, a second support member adapted to secure the primary support member to a second surface of the wall of the doorway, and at least one connecting member adapted to removeably couple the first support member and the second support member to each other. The connecting member may be adjusted to change a spacing between the first and second support members to secure the primary support member to the doorway.