Abstract: Method for preparing SSTR4 agonist compounds. Method for preparing SSTR4 agonist compounds through a diasteromerically selective cyclization reaction without the need for a separate epimerization step. Novel intermediates for preparing SSTR4 agonist compounds. Dose regimens for the treatment of pain and/or neuropathic pain, such as diabetic peripheral neuropathy, central neuropathy, or mixed neuropathy.

Abstract: A vehicle includes a vehicle body including a truck bed at least partially defining a cargo area, a vehicle interior with passenger seating, and a multi-component hard top assembly configured to selectively and removably couple to the vehicle body to provide an enclosed configuration at least partially enclosing the vehicle interior. The multi-component hard top assembly includes a rear window assembly configured to selectively and removably couple to the vehicle body.

Abstract: The present disclosure relates to certain AHR agonist compounds, their method of making, and to pharmaceutical compositions comprising the compounds and to methods of using the compounds to treat immune-mediated diseases, such as psoriasis and atopic dermatitis.

Abstract: A vehicle includes a vehicle body including a truck bed at least partially defining a cargo area, a vehicle interior with passenger seating, and a multi-component hard top assembly configured to selectively and removably couple to the vehicle body to provide an enclosed configuration at least partially enclosing the vehicle interior. The multi-component hard top assembly includes a rear window assembly configured to selectively and removably couple to the vehicle body.

Abstract: A vehicle includes a vehicle body including a truck bed at least partially defining a cargo area, a vehicle interior with passenger seating, and a multi-component hard top assembly configured to selectively and removably couple to the vehicle body to provide an enclosed configuration at least partially enclosing the vehicle interior. The multi-component hard top assembly includes a rear window assembly configured to selectively and removably couple to the vehicle body.

Abstract: A vehicle includes a vehicle body including a truck bed at least partially defining a cargo area, a vehicle interior with front passenger seating and rear passenger seating, and a modular, multi-component hard top assembly. The hard top assembly is configured to selectively and removably couple interchangeably between (i) the vehicle body to provide an enclosed configuration at least partially enclosing the vehicle interior, and (ii) the truck bed to function as a truck bed storage cover to enclose the cargo area and provide a securable storage compartment. The multi-component hard top assembly is detachable from the vehicle body to provide an open air configuration for the vehicle interior.

Abstract: A multi-functional coupler for one or more vehicle components includes a shank, a head connected to the shank, a connector carried by the shank, and a tool. The tool is carried by the head or shank spaced from the connector, and the tool has a fastener engaging portion by which a fastener may be moved to install or remove the fastener from a component. The coupler may be used to both coupled together two or more components, and to remove fasteners or other connections via the tool of the coupler. Conveniently, as the coupler is normally installed on the vehicle to couple together two or more vehicle components, the coupler is readily available to a user wanting to remove fasteners compatible/drivable with the tool of the coupler.

Abstract: A multi-functional coupler for one or more vehicle components includes a shank, a head connected to the shank, a connector carried by the shank, and a tool. The tool is carried by the head or shank spaced from the connector, and the tool has a fastener engaging portion by which a fastener may be moved to install or remove the fastener from a component. The coupler may be used to both coupled together two or more components, and to remove fasteners or other connections via the tool of the coupler. Conveniently, as the coupler is normally installed on the vehicle to couple together two or more vehicle components, the coupler is readily available to a user wanting to remove fasteners compatible/drivable with the tool of the coupler.

Abstract: A vehicle includes a vehicle body including a truck bed at least partially defining a cargo area, a vehicle interior with front passenger seating and rear passenger seating, and a modular, multi-component hard top assembly. The hard top assembly is configured to selectively and removably couple interchangeably between (i) the vehicle body to provide an enclosed configuration at least partially enclosing the vehicle interior, and (ii) the truck bed to function as a truck bed storage cover to enclose the cargo area and provide a securable storage compartment. The multi-component hard top assembly is detachable from the vehicle body to provide an open air configuration for the vehicle interior.

Abstract: A vehicle includes a vehicle body including a truck bed at least partially defining a cargo area, a vehicle interior with passenger seating, and a multi-component hard top assembly configured to selectively and removably couple to the vehicle body to provide an enclosed configuration at least partially enclosing the vehicle interior. The multi-component hard top assembly includes a rear window assembly configured to selectively and removably couple to the vehicle body.

Abstract: The present invention provides a compound, and method of inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound, having the structure:

Abstract: The present invention provides a compound, and method of inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound, having the structure:

Abstract: The present invention provides a compound, and method of inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound, having the structure:

Abstract: The present invention provides a compound, and method of inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound, having the structure:

Abstract: The present invention provides a compound, and method of inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound, having the structure:

Abstract: The present invention provides a compound, and method of inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound, having the structure:

Abstract: The present invention relates to a synthetic intermediate of the formula: and its use in a synthetic process to make compounds of the formula

Abstract: This invention provides compounds of formula I: or a pharmaceutically acceptable salt thereof; as well as a method for treating obesity, a method for treating diabetes, and a pharmaceutical composition.

Abstract: The present invention relates to a synthetic intermediate of the formula: and its use in a synthetic process to make compounds of the formula

Abstract: This invention provides compounds of formula I: or a pharmaceutically acceptable salt thereof; as well as a method for treating obesity, a method for treating diabetes, and a pharmaceutical composition.