Patents by Inventor Robert Rosenthal

Robert Rosenthal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200317776
    Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a TREM2 protein, e.g., a mammalian TREM2 or human TREM2, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.
    Type: Application
    Filed: March 30, 2020
    Publication date: October 8, 2020
    Applicant: Alector LLC
    Inventors: Tina SCHWABE, Eric BROWN, Philip KONG, Ilaria TASSI, Seung-Joo LEE, Arnon ROSENTHAL, Robert PEJCHAL, Nels P. NIELSON
  • Patent number: 10711062
    Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a CD33 protein, e.g., human CD33 or a mammalian CD33, and have improved and/or enhanced functional characteristics, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.
    Type: Grant
    Filed: August 3, 2018
    Date of Patent: July 14, 2020
    Assignee: ALECTOR LLC
    Inventors: Patricia Culp, Helen Lam, Arnon Rosenthal, Seung-Joo Lee, Nels P. Nielson, Robert Pejchal
  • Patent number: 10676525
    Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a TREM2 protein, e.g., a mammalian TREM2 or human TREM2, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.
    Type: Grant
    Filed: August 3, 2018
    Date of Patent: June 9, 2020
    Assignee: ALECTOR LLC
    Inventors: Tina Schwabe, Eric Brown, Philip Kong, Ilaria Tassi, Seung-Joo Lee, Arnon Rosenthal, Robert Pejchal, Nels P. Nielson
  • Publication number: 20200079877
    Abstract: The present disclosure provides anti-CD73 binding molecules, e.g., antibodies and antigen binding fragments thereof. Also provided are pharmaceutical formulations comprising the disclosed compositions, and methods for the diagnosis and treatment of diseases associated with CD73-expression, e.g., cancer. Such diseases can be treated, e.g., by direct therapy with the anti-CD73 binding molecules disclosed herein (e.g., naked antibodies or antibody-drug conjugates that bind CD73), by adjuvant therapy with other antigen-binding anticancer agents such as immune checkpoint inhibitors (e.g., anti-CTLA-4 and anti-PD-1 monoclonal antibodies), and/or by combination therapies where the anti-CD73 molecules are administered before, after, or concurrently with chemotherapy.
    Type: Application
    Filed: November 8, 2019
    Publication date: March 12, 2020
    Inventors: Carl HAY, Kris SACHSENMEIER, Erin SULT, Qihui Huang, Peter PAVLIK, Melissa DAMSCHRODER, Li CHENG, Gundo DIEDRICH, Jonathan RIOS-DORIA, Scott HAMMOND, Ralph MINTER, Steve RUST, Sandrine GUILLARD, Robert HOLLINGSWORTH, Lutz JERMUTUS, Nicholas DURHAM, Ching Ching LEOW, Mary ANTONYSAMY, James GEOGHEGAN, Xiaojun LU, Kim ROSENTHAL
  • Publication number: 20200072007
    Abstract: A sub connects a gun string to a hydraulically activated setting tool for setting an auxiliary tool in a well. The sub includes a housing that prevents a well fluid from entering inside the housing; a plug that covers a hole made in a wall of the housing; and an explosive mechanism located inside the housing and configured to break the plug to open the hole to achieve fluid communication between an outside and the inside of the sub.
    Type: Application
    Filed: November 6, 2019
    Publication date: March 5, 2020
    Inventors: Robert DAVIS, Wayne ROSENTHAL, Kevin GEORGE, David WESSON, Michael WROBLICKY, Jeremy CASTANEDA
  • Patent number: 10556968
    Abstract: The present disclosure provides anti-CD73 binding molecules, e.g., antibodies and antigen binding fragments thereof. Also provided are pharmaceutical formulations comprising the disclosed compositions, and methods for the diagnosis and treatment of diseases associated with CD73-expression, e.g., cancer. Such diseases can be treated, e.g., by direct therapy with the anti-CD73 binding molecules disclosed herein (e.g., naked antibodies or antibody-drug conjugates that bind CD73), by adjuvant therapy with other antigen-binding anticancer agents such as immune checkpoint inhibitors (e.g., anti-CTLA-4 and anti-PD-1 monoclonal antibodies), and/or by combination therapies where the anti-CD73 molecules are administered before, after, or concurrently with chemotherapy.
    Type: Grant
    Filed: April 4, 2019
    Date of Patent: February 11, 2020
    Assignee: MEDIMMUNE LIMITED
    Inventors: Carl Hay, Kris Sachsenmeier, Erin Sult, Qihui Huang, Peter Pavlik, Melissa Damschroder, Li Cheng, Gundo Diedrich, Jonathan Rios-Doria, Scott Hammond, Ralph Minter, Steve Rust, Sandrine Guillard, Robert Hollingsworth, Lutz Jermutus, Nicholas Durham, Ching Ching Leow, Mary Antonysamy, James Geoghegan, Xiaojun Lu, Kim Rosenthal
  • Patent number: 10546250
    Abstract: The present disclosure describes an automated, cognitive based computing system using artificial intelligence (AI) and machine learning algorithms to sense, predict, and infer network conditions, configured to dynamically manage transmission of information between communication nodes. The communication nodes comprise orbital nodes positioned in orbit above earth and terrestrial nodes coupled with earth interconnected via a hybrid mesh network topology.
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: January 28, 2020
    Assignee: LASER LIGHT COMMUNICATIONS LLC
    Inventors: Robert H. Brumley, II, Robert H. Brumley, III, Richard Rosenthal, Steven Birrell, Michael J. Reedy, Fletcher W. Brumley
  • Publication number: 20200024348
    Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, affinity-matured, humanized antibodies, antibody fragments, etc., that specifically bind a Sortilin protein, e.g., human Sortilin or mammalian Sortilin, and have improved and/or enhanced functional characteristics, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.
    Type: Application
    Filed: July 12, 2019
    Publication date: January 23, 2020
    Applicant: Alector LLC
    Inventors: Tina SCHWABE, Michael KURNELLAS, Arnon ROSENTHAL, Robert PEJCHAL, Anthony B. COOPER
  • Publication number: 20190383034
    Abstract: A non-swelling joint tape for use with drywall applications includes a tapered trim strip body extending along a central body axis and a non-swelling backing paper. The tapered trim strip body includes a first surface, a second surface opposite the first surface, a first side, and a second side opposite the first side, and is at least partially constructed from a first dimensionally stable material. The non-swelling backing paper is at least partially secured to the second surface of the tapered trim strip body and is at least partially constructed from a second dimensionally stable material. The tapered trim strip body is dimensioned such that a first thickness between the first surface and the second surface at the central body axis is greater than a second thickness between the first surface and the second surface at the first side and the second side.
    Type: Application
    Filed: April 10, 2019
    Publication date: December 19, 2019
    Inventors: Robert Negri, Guy Rosenthal, Salvatore Immordino
  • Publication number: 20190382621
    Abstract: A gap finishing tape for use with drywall applications includes a trim strip body extending along a central body axis, a hot melt adhesive extending along the central body axis, and a backing paper. The trim strip body includes a first surface, a second surface opposite the first surface, a first side, and a second side opposite the first side, and is at least partially constructed from a metallic material. The backing paper is at least partially secured to the second surface of the trim strip body. The trim strip body is at least partially embedded in the hot melt adhesive.
    Type: Application
    Filed: April 10, 2019
    Publication date: December 19, 2019
    Inventors: Guy Rosenthal, Terry Rosenstiel, Salvatore Immordino, Robert Negri
  • Patent number: 10502013
    Abstract: A hydraulically activated setting tool for setting an auxiliary tool in a well, the setting tool including a housing that prevents a well fluid from entering inside the housing; a floating piston placed inside the housing and closing an end of a pressure chamber; an attached piston placed inside the housing and configured to actuate the auxiliary tool; a fluid chamber located between the floating piston and the attached piston, wherein the fluid chamber holds a fluid; and a communication element configured to establish a fluid communication between an outside and an inside of the housing. The fluid communication makes a well fluid in the well to directly act on the floating piston.
    Type: Grant
    Filed: November 16, 2018
    Date of Patent: December 10, 2019
    Assignee: GEODYNAMICS, INC.
    Inventors: Robert Davis, Wayne Rosenthal, Kevin George, David Wesson, Michael Wroblicky, Jeremy Castaneda
  • Publication number: 20190365983
    Abstract: A medication delivery monitoring device is disclosed. The device includes a user interface configured to receive input information, and a sensor configured to measure a plurality of fluid state parameters of a fluid delivery channel through which the medication is delivered by a vascular access device (VAD) to an infusion site region of the patient. The device also includes a processor configured to determine a state of the infusion site region based on the plurality of measured fluid state parameters and the input information, and an output device configured to provide a communication regarding the state of the infusion site region. Methods and computer-readable mediums for monitoring medication delivery are also disclosed.
    Type: Application
    Filed: June 24, 2019
    Publication date: December 5, 2019
    Inventors: Robert Dwaine BUTTERFIELD, Brian STOCK, Melissa STRAIT, Harry DUDLEY, Stephen ROSENTHAL
  • Patent number: 10438769
    Abstract: A scanning electron microscopy (SEM) system includes a plurality of electron beam sources configured to generate a primary electron beam. The SEM system includes an electron-optical column array with a plurality of electron-optical columns. An electron-optical column includes a plurality of electron-optical elements. The plurality of electron-optical elements includes a deflector layer configured to be driven via a common controller shared by at least some of the plurality of electron-optical columns and includes a trim deflector layer configured to be driven by an individual controller. The plurality of electron-optical elements is arranged to form an electron beam channel configured to direct the primary electron beam to a sample secured on a stage, which emits an electron beam in response to the primary electron beam. The electron-optical column includes an electron detector. The electron beam channel is configured to direct the electron beam to the electron detector.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: October 8, 2019
    Assignee: KLA-Tencor Corporation
    Inventors: Alex Lipkind, Alon Rosenthal, Frank Chilese, John Gerling, Lawrence Muray, Robert Haynes
  • Publication number: 20190292274
    Abstract: The present disclosure provides anti-CD73 binding molecules, e.g., antibodies and antigen binding fragments thereof. Also provided are pharmaceutical formulations comprising the disclosed compositions, and methods for the diagnosis and treatment of diseases associated with CD73-expression, e.g., cancer. Such diseases can be treated, e.g., by direct therapy with the anti-CD73 binding molecules disclosed herein (e.g., naked antibodies or antibody-drug conjugates that bind CD73), by adjuvant therapy with other antigen-binding anticancer agents such as immune checkpoint inhibitors (e.g., anti-CTLA-4 and anti-PD-1 monoclonal antibodies), and/or by combination therapies where the anti-CD73 molecules are administered before, after, or concurrently with chemotherapy.
    Type: Application
    Filed: April 4, 2019
    Publication date: September 26, 2019
    Inventors: Carl HAY, Kris SACHSENMEIER, Erin SULT, Qihui HUANG, Peter PAVLIK, Melissa DAMSCHRODER, Li CHENG, Gundo DIEDRICH, Jonathan RIOS-DORIA, Scott HAMMOND, Ralph MINTER, Steve RUST, Sandrine GUILLARD, Robert HOLLINGSWORTH, Lutz JERMUTUS, Nicholas DURHAM, Ching Ching LEOW, Mary ANTONYSAMY, James GEOGHEGAN, Xiaojun LU, Kim ROSENTHAL
  • Publication number: 20190242205
    Abstract: A hydraulically activated setting tool for setting an auxiliary tool in a well, the setting tool including a housing that prevents a well fluid from entering inside the housing; a floating piston placed inside the housing and closing an end of a pressure chamber; an attached piston placed inside the housing and configured to actuate the auxiliary tool; a fluid chamber located between the floating piston and the attached piston, wherein the fluid chamber holds a fluid; and a communication element configured to establish a fluid communication between an outside and an inside of the housing. The fluid communication makes a well fluid in the well to directly act on the floating piston.
    Type: Application
    Filed: November 16, 2018
    Publication date: August 8, 2019
    Inventors: Robert DAVIS, Wayne ROSENTHAL, Kevin GEORGE, David WESSON, Michael WROBLICKY, Jeremy CASTANEDA
  • Publication number: 20190205789
    Abstract: The present disclosure describes an automated, cognitive based computing system using artificial intelligence (AI) and machine learning algorithms to sense, predict, and infer network conditions, configured to dynamically manage transmission of information between communication nodes. The communication nodes comprise orbital nodes positioned in orbit above earth and terrestrial nodes coupled with earth interconnected via a hybrid mesh network topology.
    Type: Application
    Filed: March 8, 2019
    Publication date: July 4, 2019
    Inventors: Robert H. BRUMLEY, II, Robert H. BRUMLEY, III, Richard ROSENTHAL, Steven BIRRELL, Michael J. REEDY, Fletcher W. BRUMLEY
  • Patent number: 10328199
    Abstract: A medication delivery monitoring device is disclosed. The device includes a user interface configured to receive input information, and a sensor configured to measure a plurality of fluid state parameters of a fluid delivery channel through which the medication is delivered by a vascular access device (VAD) to an infusion site region of the patient. The device also includes a processor configured to determine a state of the infusion site region based on the plurality of measured fluid state parameters and the input information, and an output device configured to provide a communication regarding the state of the infusion site region. Methods and computer-readable mediums for monitoring medication delivery are also disclosed.
    Type: Grant
    Filed: December 5, 2016
    Date of Patent: June 25, 2019
    Assignee: CareFusion 303, Inc.
    Inventors: Robert Dwaine Butterfield, Brian Stock, Melissa Strait, Harry Dudley, Stephen Rosenthal
  • Patent number: 10308718
    Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compostions in preventing, reducing risk, or treating an individual in need thereof.
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: June 4, 2019
    Assignee: ALECTOR LLC
    Inventors: Arnon Rosenthal, Tina Schwabe, Michael Kurnellas, Robert Pejchal, Anthony B. Cooper
  • Patent number: 10287362
    Abstract: The present disclosure provides anti-CD73 binding molecules, e.g., antibodies and antigen binding fragments thereof. Also provided are pharmaceutical formulations comprising the disclosed compositions, and methods for the diagnosis and treatment of diseases associated with CD73-expression, e.g., cancer. Such diseases can be treated, e.g., by direct therapy with the anti-CD73 binding molecules disclosed herein (e.g., naked antibodies or antibody-drug conjugates that bind CD73), by adjuvant therapy with other antigen-binding anticancer agents such as immune checkpoint inhibitors (e.g., anti-CTLA-4 and anti-PD-1 monoclonal antibodies), and/or by combination therapies where the anti-CD73 molecules are administered before, after, or concurrently with chemotherapy.
    Type: Grant
    Filed: February 23, 2018
    Date of Patent: May 14, 2019
    Assignee: MedImmune Limited
    Inventors: Carl Hay, Kris Sachsenmeier, Erin Sult, Qihui Huang, Peter Pavlik, Melissa Damschroder, Li Cheng, Gundo Diedrich, Jonathan Rios-Doria, Scott Hammond, Ralph Minter, Steve Rust, Sandrine Guillard, Robert Hollingsworth, Lutz Jermutus, Nicholas Durham, Ching Ching Leow, Mary Antonysamy, James Geoghegan, Xiaojun Lu, Kim Rosenthal
  • Publication number: 20180281141
    Abstract: An indexing tool for positioning a workpiece, the tool comprising a block having sides, the sides defining a regular polygon. The block has a central opening, and a threaded hole extending at a right angle to the central opening and into and through one of the sides. The block also has a V notch in the block wall opposite the threaded hole, the threaded hole being adapted to have received therein a like threaded set screw.
    Type: Application
    Filed: March 23, 2018
    Publication date: October 4, 2018
    Inventor: Timm Robert Rosenthal